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• W1991460324 abstract "We have constructed two fusion proteins, DAB 389 –mIL‐3 and DAB 389 ‐(Gly 4 Ser) 2 –mIL‐3, in which the receptor‐binding domain of diphtheria toxin is replaced by mouse interleukin‐3 (IL‐3). Cytotoxic activity of the fusion toxins was observed on three out of six cell lines assayed. This toxicity was mediated through binding to the IL‐3 receptor as it was inhibited in a dose‐dependent manner with murine IL‐3 or anti‐IL‐3 neutralizing antibodies. DAB 389 –(Gly 4 Ser) 2 ‐mIL‐3 was up to 5 times more toxic than DAB 389 –mIL‐3, depending on the cell line (0.8×10 −10 M<IC 50 <3×10 −10 M). These proteins can be used for the detection of IL‐3 receptors on mouse cells and should allow for the selective elimination of IL‐3 receptor‐positive pluripotent hematopoietic stem cells prior to bone marrow transplantation." @default.
• W1991460324 created "2016-06-24" @default.
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• W1991460324 date "1997-04-07" @default.
• W1991460324 modified "2023-10-14" @default.
• W1991460324 title "Characterization and receptor specific toxicity of two diphtheria toxin-related interleukin-3 fusion proteins DAB₃₈₉-mIL-3 and DAB₃₈₉-(Gly₄Ser)₂-mIL-3" @default.
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• W1991460324 doi "https://doi.org/10.1016/s0014-5793(97)00243-3" @default.
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