FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991464080> ?p ?o ?g. }

• W1991464080 endingPage "2718" @default.
• W1991464080 startingPage "2703" @default.
• W1991464080 abstract "FAN (factor associated with neutral sphingomyelinase [N-SMase] activation) exhibits striking structural homologies to Lyst (lysosomal trafficking regulator), a BEACH protein whose inactivation causes formation of giant lysosomes/Chediak-Higashi syndrome. Here, we show that cells lacking FAN show a statistically significant increase in lysosome size (although less pronounced as Lyst), pointing to previously unrecognized functions of FAN in regulation of the lysosomal compartment. Since FAN regulates activation of N-SMase in complex with receptor for activated C-kinase (RACK)1, a scaffolding protein that recruits and stabilizes activated protein kinase C (PKC) isotypes at cellular membranes, and since an abnormal (calpain-mediated) downregulation/membrane recruitment of PKC has been linked to the defects observed in Lyst-deficient cells, we assessed whether PKC is also of relevance in FAN signaling. Our results demonstrate that activation of PKC is not required for regulation of N-SMase by FAN/RACK1. Conversely, activation of PKC and recruitment/stabilization by RACK1 occurs uniformly in the presence or absence of FAN (and equally, Lyst). Furthermore, regulation of lysosome size by FAN is not coupled to an abnormal downregulation/membrane recruitment of PKC by calpain. Identical results were obtained for Lyst, questioning the previously reported relevance of PKC for formation of giant lysosomes and in Chediak-Higashi syndrome. In summary, FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC." @default.
• W1991464080 created "2016-06-24" @default.
• W1991464080 creator A5033710694 @default.
• W1991464080 creator A5040120305 @default.
• W1991464080 creator A5049829923 @default.
• W1991464080 creator A5049862048 @default.
• W1991464080 creator A5062315759 @default.
• W1991464080 creator A5069634632 @default.
• W1991464080 creator A5069823119 @default.
• W1991464080 creator A5070597784 @default.
• W1991464080 creator A5088588234 @default.
• W1991464080 date "2007-07-01" @default.
• W1991464080 modified "2023-09-30" @default.
• W1991464080 title "The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C" @default.
• W1991464080 cites W1533548496 @default.
• W1991464080 cites W1566547188 @default.
• W1991464080 cites W1570667313 @default.
• W1991464080 cites W1593161820 @default.
• W1991464080 cites W1676371164 @default.
• W1991464080 cites W1726121095 @default.
• W1991464080 cites W1837586904 @default.
• W1991464080 cites W1947286872 @default.
• W1991464080 cites W1969857515 @default.
• W1991464080 cites W1980921054 @default.
• W1991464080 cites W2012288527 @default.
• W1991464080 cites W2013944173 @default.
• W1991464080 cites W2017649890 @default.
• W1991464080 cites W2019107970 @default.
• W1991464080 cites W2033859595 @default.
• W1991464080 cites W2055594078 @default.
• W1991464080 cites W2065596115 @default.
• W1991464080 cites W2069717498 @default.
• W1991464080 cites W2081048050 @default.
• W1991464080 cites W2090582665 @default.
• W1991464080 cites W2103677243 @default.
• W1991464080 cites W2106763550 @default.
• W1991464080 cites W2110671766 @default.
• W1991464080 cites W2113470143 @default.
• W1991464080 cites W2125093077 @default.
• W1991464080 cites W2129001359 @default.
• W1991464080 cites W2131865971 @default.
• W1991464080 cites W2135935249 @default.
• W1991464080 cites W2136149489 @default.
• W1991464080 cites W2143859241 @default.
• W1991464080 cites W2145541801 @default.
• W1991464080 cites W2151411140 @default.
• W1991464080 cites W2156638024 @default.
• W1991464080 cites W2159788013 @default.
• W1991464080 cites W2160648492 @default.
• W1991464080 cites W2162367837 @default.
• W1991464080 cites W2168967331 @default.
• W1991464080 cites W2170844178 @default.
• W1991464080 cites W2327883130 @default.
• W1991464080 cites W2426269696 @default.
• W1991464080 cites W4313347617 @default.
• W1991464080 doi "https://doi.org/10.1016/j.yexcr.2007.04.020" @default.
• W1991464080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2988431" @default.
• W1991464080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17512928" @default.
• W1991464080 hasPublicationYear "2007" @default.
• W1991464080 type Work @default.
• W1991464080 sameAs 1991464080 @default.
• W1991464080 citedByCount "19" @default.
• W1991464080 countsByYear W19914640802013 @default.
• W1991464080 countsByYear W19914640802014 @default.
• W1991464080 countsByYear W19914640802015 @default.
• W1991464080 countsByYear W19914640802016 @default.
• W1991464080 countsByYear W19914640802018 @default.
• W1991464080 countsByYear W19914640802020 @default.
• W1991464080 crossrefType "journal-article" @default.
• W1991464080 hasAuthorship W1991464080A5033710694 @default.
• W1991464080 hasAuthorship W1991464080A5040120305 @default.
• W1991464080 hasAuthorship W1991464080A5049829923 @default.
• W1991464080 hasAuthorship W1991464080A5049862048 @default.
• W1991464080 hasAuthorship W1991464080A5062315759 @default.
• W1991464080 hasAuthorship W1991464080A5069634632 @default.
• W1991464080 hasAuthorship W1991464080A5069823119 @default.
• W1991464080 hasAuthorship W1991464080A5070597784 @default.
• W1991464080 hasAuthorship W1991464080A5088588234 @default.
• W1991464080 hasBestOaLocation W19914640802 @default.
• W1991464080 hasConcept C104317684 @default.
• W1991464080 hasConcept C127561419 @default.
• W1991464080 hasConcept C181199279 @default.
• W1991464080 hasConcept C190283241 @default.
• W1991464080 hasConcept C195794163 @default.
• W1991464080 hasConcept C2777851122 @default.
• W1991464080 hasConcept C2780216420 @default.
• W1991464080 hasConcept C55493867 @default.
• W1991464080 hasConcept C56928146 @default.
• W1991464080 hasConcept C62478195 @default.
• W1991464080 hasConcept C86803240 @default.
• W1991464080 hasConcept C95444343 @default.
• W1991464080 hasConceptScore W1991464080C104317684 @default.
• W1991464080 hasConceptScore W1991464080C127561419 @default.
• W1991464080 hasConceptScore W1991464080C181199279 @default.
• W1991464080 hasConceptScore W1991464080C190283241 @default.
• W1991464080 hasConceptScore W1991464080C195794163 @default.
• W1991464080 hasConceptScore W1991464080C2777851122 @default.
• W1991464080 hasConceptScore W1991464080C2780216420 @default.

• next