Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991467571> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1991467571 endingPage "104" @default.
- W1991467571 startingPage "99" @default.
- W1991467571 abstract "Long-term potentiation (LTP) and long-term depression of synaptic transmission in the hippocampus are widely studied models of learning and memory processes. The role of ATP-regulated K+ channels (KATP+ channels), which are abundant in the brain, has not yet been studied in long-term potentiation or long-term depression. We investigated whether KATP+ channel inhibition by the highly selective KATP+-channel blocker 1-[[5-[2-(5-tert-butyl-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl]-3-methylthiourea (HMR-1372), a novel putative class III antiarrhythmic, affects long-term potentiation or the long-term depression induced by 3,5-dihydroxyphenylglycine (30 μM) in submerged rat hippocampal slices. HMR-1372 (10 μM) did not affect basal synaptic transmission, paired pulse inhibition, long-term depression or long-term potentiation elicited by a weak (weak long-term potentiation) tetanus, but significantly amplified the long-term efficacy of long-term potentiation elicited by a strong tetanus (strong long-term potentiation). The KATP+-channel inhibitor glibenclamide (20 μM) also ameliorated only strong long-term potentiation. Our data suggest that KATP+ channels are activated during or after induction of long-term potentiation and play a role in controlling synaptic excitability." @default.
- W1991467571 created "2016-06-24" @default.
- W1991467571 creator A5003279394 @default.
- W1991467571 creator A5021671256 @default.
- W1991467571 creator A5073636267 @default.
- W1991467571 creator A5086710168 @default.
- W1991467571 creator A5088492004 @default.
- W1991467571 date "2004-10-01" @default.
- W1991467571 modified "2023-09-27" @default.
- W1991467571 title "The ATP-regulated K+-channel inhibitor HMR-1372 affects synaptic plasticity in hippocampal slices" @default.
- W1991467571 cites W1793516482 @default.
- W1991467571 cites W1834174605 @default.
- W1991467571 cites W1901856024 @default.
- W1991467571 cites W1983011541 @default.
- W1991467571 cites W1986461003 @default.
- W1991467571 cites W1995919912 @default.
- W1991467571 cites W1998603233 @default.
- W1991467571 cites W2002585270 @default.
- W1991467571 cites W2019353914 @default.
- W1991467571 cites W2029247375 @default.
- W1991467571 cites W2031332054 @default.
- W1991467571 cites W2033066785 @default.
- W1991467571 cites W2043899013 @default.
- W1991467571 cites W2058591676 @default.
- W1991467571 cites W2058758799 @default.
- W1991467571 cites W2078869741 @default.
- W1991467571 cites W2087389261 @default.
- W1991467571 cites W2101752125 @default.
- W1991467571 cites W2106766847 @default.
- W1991467571 cites W2107862591 @default.
- W1991467571 cites W2137083867 @default.
- W1991467571 cites W2165967474 @default.
- W1991467571 cites W2169548779 @default.
- W1991467571 cites W4234220197 @default.
- W1991467571 doi "https://doi.org/10.1016/j.ejphar.2004.08.046" @default.
- W1991467571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15464094" @default.
- W1991467571 hasPublicationYear "2004" @default.
- W1991467571 type Work @default.
- W1991467571 sameAs 1991467571 @default.
- W1991467571 citedByCount "15" @default.
- W1991467571 countsByYear W19914675712015 @default.
- W1991467571 countsByYear W19914675712016 @default.
- W1991467571 countsByYear W19914675712017 @default.
- W1991467571 countsByYear W19914675712018 @default.
- W1991467571 countsByYear W19914675712021 @default.
- W1991467571 countsByYear W19914675712022 @default.
- W1991467571 crossrefType "journal-article" @default.
- W1991467571 hasAuthorship W1991467571A5003279394 @default.
- W1991467571 hasAuthorship W1991467571A5021671256 @default.
- W1991467571 hasAuthorship W1991467571A5073636267 @default.
- W1991467571 hasAuthorship W1991467571A5086710168 @default.
- W1991467571 hasAuthorship W1991467571A5088492004 @default.
- W1991467571 hasConcept C148762608 @default.
- W1991467571 hasConcept C160268369 @default.
- W1991467571 hasConcept C169760540 @default.
- W1991467571 hasConcept C170493617 @default.
- W1991467571 hasConcept C185592680 @default.
- W1991467571 hasConcept C200170125 @default.
- W1991467571 hasConcept C25274449 @default.
- W1991467571 hasConcept C2781161787 @default.
- W1991467571 hasConcept C55493867 @default.
- W1991467571 hasConcept C61174792 @default.
- W1991467571 hasConcept C73009533 @default.
- W1991467571 hasConcept C86803240 @default.
- W1991467571 hasConcept C98229152 @default.
- W1991467571 hasConceptScore W1991467571C148762608 @default.
- W1991467571 hasConceptScore W1991467571C160268369 @default.
- W1991467571 hasConceptScore W1991467571C169760540 @default.
- W1991467571 hasConceptScore W1991467571C170493617 @default.
- W1991467571 hasConceptScore W1991467571C185592680 @default.
- W1991467571 hasConceptScore W1991467571C200170125 @default.
- W1991467571 hasConceptScore W1991467571C25274449 @default.
- W1991467571 hasConceptScore W1991467571C2781161787 @default.
- W1991467571 hasConceptScore W1991467571C55493867 @default.
- W1991467571 hasConceptScore W1991467571C61174792 @default.
- W1991467571 hasConceptScore W1991467571C73009533 @default.
- W1991467571 hasConceptScore W1991467571C86803240 @default.
- W1991467571 hasConceptScore W1991467571C98229152 @default.
- W1991467571 hasIssue "1-2" @default.
- W1991467571 hasLocation W19914675711 @default.
- W1991467571 hasLocation W19914675712 @default.
- W1991467571 hasOpenAccess W1991467571 @default.
- W1991467571 hasPrimaryLocation W19914675711 @default.
- W1991467571 hasRelatedWork W1870692950 @default.
- W1991467571 hasRelatedWork W1971553391 @default.
- W1991467571 hasRelatedWork W1999907002 @default.
- W1991467571 hasRelatedWork W2018213389 @default.
- W1991467571 hasRelatedWork W2401673187 @default.
- W1991467571 hasRelatedWork W2681075357 @default.
- W1991467571 hasRelatedWork W2809753226 @default.
- W1991467571 hasRelatedWork W2916442235 @default.
- W1991467571 hasRelatedWork W3134957322 @default.
- W1991467571 hasRelatedWork W4229646661 @default.
- W1991467571 hasVolume "502" @default.
- W1991467571 isParatext "false" @default.
- W1991467571 isRetracted "false" @default.
- W1991467571 magId "1991467571" @default.
- W1991467571 workType "article" @default.