FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991467772> ?p ?o ?g. }

• W1991467772 endingPage "35" @default.
• W1991467772 startingPage "35" @default.
• W1991467772 abstract "To compare the efficacy of cell-free derivatives from Bone marrow derived human mesenchymal stem cells (hMSCs) in wound therapy.hMSCs have been shown to play an important role in wound therapy. The present study sought to compare efficacy of hMSCs and cell-free derivatives of hMSCs, which may be clinically more relevant as they are easier to prepare, formulate and transport. hMSCs were isolated from human bone marrow and cultured. Multi lineage differentiation of hMSCs was performed to confirm their identity. The ability of hMSCs to migrate was evaluated using in vitro and in vivo migration assays. Cell lysates and conditioned medium concentrate was prepared from hMSCs (see Methods for details). Wounds were induced in mice and wound areas were measure before and after cell and cell-free derivative treatment. RNA and proteins were extracted from the skin and cytokine levels were measured.Co-culture of hMSCs with keratinocytes resulted in increased expression of CXCL-12 (SDF1) and ENA78 (CXCL-5) in the conditioned media indicating that the hMSCs can respond to signals from keratinocytes. Accelerated wound closure was observed when hMSCs were injected near the site of excisional wounds in athymic as well as NOD/SCID mice. Interestingly, cell-free lysates prepared from hMSCs were also effective in inducing accelerated wound closure and increased expression of SDF1 and CXCL-5 at the wound bed. Additionally, concentrated media from hMSCs as well as an emulsion containing lysates prepared from hMSCs was also found to be more effective in rapid re-epithelialization than fibroblasts or vehicle-alone control. Use of cell-free derivatives may help replace expensive wound care approaches including use of growth factors, epidermal/dermal substitutes, synthetic membranes, cytokines, and matrix components, and most importantly avoid transmission of pathogens from human and animal products.These results encourage development of derivatives of hMSCs for wound care and re-epithelialization applications." @default.
• W1991467772 created "2016-06-24" @default.
• W1991467772 creator A5044024576 @default.
• W1991467772 creator A5058740700 @default.
• W1991467772 creator A5064988009 @default.
• W1991467772 date "2012-01-01" @default.
• W1991467772 modified "2023-09-26" @default.
• W1991467772 title "Cell-free derivatives from mesenchymal stem cells are effective in wound therapy" @default.
• W1991467772 cites W1920534265 @default.
• W1991467772 cites W1969592520 @default.
• W1991467772 cites W1975255476 @default.
• W1991467772 cites W1979983097 @default.
• W1991467772 cites W1981269419 @default.
• W1991467772 cites W1986726530 @default.
• W1991467772 cites W1991350431 @default.
• W1991467772 cites W1996692762 @default.
• W1991467772 cites W2005943573 @default.
• W1991467772 cites W2015188671 @default.
• W1991467772 cites W2015623756 @default.
• W1991467772 cites W2018126662 @default.
• W1991467772 cites W2030281917 @default.
• W1991467772 cites W2032377131 @default.
• W1991467772 cites W2035040282 @default.
• W1991467772 cites W2037629073 @default.
• W1991467772 cites W2038775969 @default.
• W1991467772 cites W2047824295 @default.
• W1991467772 cites W2059422618 @default.
• W1991467772 cites W2066842581 @default.
• W1991467772 cites W2073420780 @default.
• W1991467772 cites W2088938583 @default.
• W1991467772 cites W2089738396 @default.
• W1991467772 cites W2095132685 @default.
• W1991467772 cites W2120472250 @default.
• W1991467772 cites W2128301515 @default.
• W1991467772 cites W2141248581 @default.
• W1991467772 cites W2142678690 @default.
• W1991467772 cites W2145873932 @default.
• W1991467772 cites W2159193579 @default.
• W1991467772 cites W2159999899 @default.
• W1991467772 cites W2161214210 @default.
• W1991467772 cites W2325727928 @default.
• W1991467772 cites W4250620805 @default.
• W1991467772 doi "https://doi.org/10.4252/wjsc.v4.i5.35" @default.
• W1991467772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3443710" @default.
• W1991467772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22993660" @default.
• W1991467772 hasPublicationYear "2012" @default.
• W1991467772 type Work @default.
• W1991467772 sameAs 1991467772 @default.
• W1991467772 citedByCount "40" @default.
• W1991467772 countsByYear W19914677722013 @default.
• W1991467772 countsByYear W19914677722014 @default.
• W1991467772 countsByYear W19914677722015 @default.
• W1991467772 countsByYear W19914677722016 @default.
• W1991467772 countsByYear W19914677722017 @default.
• W1991467772 countsByYear W19914677722018 @default.
• W1991467772 countsByYear W19914677722019 @default.
• W1991467772 countsByYear W19914677722020 @default.
• W1991467772 countsByYear W19914677722021 @default.
• W1991467772 countsByYear W19914677722022 @default.
• W1991467772 countsByYear W19914677722023 @default.
• W1991467772 crossrefType "journal-article" @default.
• W1991467772 hasAuthorship W1991467772A5044024576 @default.
• W1991467772 hasAuthorship W1991467772A5058740700 @default.
• W1991467772 hasAuthorship W1991467772A5064988009 @default.
• W1991467772 hasBestOaLocation W19914677721 @default.
• W1991467772 hasConcept C10882517 @default.
• W1991467772 hasConcept C142724271 @default.
• W1991467772 hasConcept C1491633281 @default.
• W1991467772 hasConcept C150903083 @default.
• W1991467772 hasConcept C185592680 @default.
• W1991467772 hasConcept C198826908 @default.
• W1991467772 hasConcept C202751555 @default.
• W1991467772 hasConcept C203014093 @default.
• W1991467772 hasConcept C207001950 @default.
• W1991467772 hasConcept C2780269544 @default.
• W1991467772 hasConcept C28328180 @default.
• W1991467772 hasConcept C55493867 @default.
• W1991467772 hasConcept C71924100 @default.
• W1991467772 hasConcept C86803240 @default.
• W1991467772 hasConcept C95444343 @default.
• W1991467772 hasConceptScore W1991467772C10882517 @default.
• W1991467772 hasConceptScore W1991467772C142724271 @default.
• W1991467772 hasConceptScore W1991467772C1491633281 @default.
• W1991467772 hasConceptScore W1991467772C150903083 @default.
• W1991467772 hasConceptScore W1991467772C185592680 @default.
• W1991467772 hasConceptScore W1991467772C198826908 @default.
• W1991467772 hasConceptScore W1991467772C202751555 @default.
• W1991467772 hasConceptScore W1991467772C203014093 @default.
• W1991467772 hasConceptScore W1991467772C207001950 @default.
• W1991467772 hasConceptScore W1991467772C2780269544 @default.
• W1991467772 hasConceptScore W1991467772C28328180 @default.
• W1991467772 hasConceptScore W1991467772C55493867 @default.
• W1991467772 hasConceptScore W1991467772C71924100 @default.
• W1991467772 hasConceptScore W1991467772C86803240 @default.
• W1991467772 hasConceptScore W1991467772C95444343 @default.
• W1991467772 hasIssue "5" @default.
• W1991467772 hasLocation W19914677721 @default.
• W1991467772 hasLocation W19914677722 @default.

• next