FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991468086> ?p ?o ?g. }

• W1991468086 endingPage "39" @default.
• W1991468086 startingPage "33" @default.
• W1991468086 abstract "Danofloxacin is a fluoroquinolone developed for use in veterinary medicine. Its concentrations and pharmacokinetic profile in plasma, milk and tissues of lactating dairy cows were determined, and its milk withdrawal time (WT) calculated. Twenty-one dairy cows received a single subcutaneous administration of 18% mesylate danofloxacin salt (6 mgkg(-1)). Plasma and milk samples were obtained at different times until 48 h. Groups of three animals were sacrificed at different post-administration times and tissue samples (mammary gland, uterus, duodenum, jejunum, ileum, colon and mesenteric lymph nodes) obtained. Danofloxacin concentrations were determined by liquid chromatography with fluorescence detection. The milk WT was calculated by the Time to Safe Concentration method (Software WTM 1.4, EMEA). Danofloxacin was rapidly absorbed and its distribution from plasma to all sampled tissues and milk was extensive. Milk and tissues concentrations were several times above those found in plasma. Plasma area under the curve (AUCp) was 9.69 microghmL(-1) and its elimination half life (T(beta)(1/2)) was 12.53 h. AUC values for the various tissues and milk greatly exceeded AUCp. T(beta)(1/2) from milk and tissues ranged between 4.57 and 21.91 h and the milk withdrawal time was 73.48 h. The reported results support the potential use of danofloxacin in the treatment of mastitis and other infections in milk cows with 3 days of withdrawal." @default.
• W1991468086 created "2016-06-24" @default.
• W1991468086 creator A5003227116 @default.
• W1991468086 creator A5037510528 @default.
• W1991468086 creator A5076168662 @default.
• W1991468086 creator A5089156735 @default.
• W1991468086 creator A5065850474 @default.
• W1991468086 date "2009-04-01" @default.
• W1991468086 modified "2023-09-23" @default.
• W1991468086 title "Concentrations of danofloxacin 18% solution in plasma, milk and tissues after subcutaneous injection in dairy cows" @default.
• W1991468086 cites W138394831 @default.
• W1991468086 cites W1581165092 @default.
• W1991468086 cites W1973237454 @default.
• W1991468086 cites W1981775647 @default.
• W1991468086 cites W1981975039 @default.
• W1991468086 cites W1995784718 @default.
• W1991468086 cites W2000925359 @default.
• W1991468086 cites W2009310588 @default.
• W1991468086 cites W2018934346 @default.
• W1991468086 cites W2026121899 @default.
• W1991468086 cites W2034173460 @default.
• W1991468086 cites W2036309589 @default.
• W1991468086 cites W2041373870 @default.
• W1991468086 cites W2047994548 @default.
• W1991468086 cites W2068301725 @default.
• W1991468086 cites W2087662606 @default.
• W1991468086 cites W2091765720 @default.
• W1991468086 cites W2108310800 @default.
• W1991468086 cites W2108672994 @default.
• W1991468086 cites W2121890022 @default.
• W1991468086 cites W2125194413 @default.
• W1991468086 cites W2133517303 @default.
• W1991468086 cites W2146190604 @default.
• W1991468086 cites W2148620725 @default.
• W1991468086 doi "https://doi.org/10.1016/j.aca.2008.09.055" @default.
• W1991468086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19286009" @default.
• W1991468086 hasPublicationYear "2009" @default.
• W1991468086 type Work @default.
• W1991468086 sameAs 1991468086 @default.
• W1991468086 citedByCount "19" @default.
• W1991468086 countsByYear W19914680862012 @default.
• W1991468086 countsByYear W19914680862013 @default.
• W1991468086 countsByYear W19914680862015 @default.
• W1991468086 countsByYear W19914680862017 @default.
• W1991468086 countsByYear W19914680862018 @default.
• W1991468086 countsByYear W19914680862019 @default.
• W1991468086 countsByYear W19914680862020 @default.
• W1991468086 countsByYear W19914680862021 @default.
• W1991468086 countsByYear W19914680862022 @default.
• W1991468086 countsByYear W19914680862023 @default.
• W1991468086 crossrefType "journal-article" @default.
• W1991468086 hasAuthorship W1991468086A5003227116 @default.
• W1991468086 hasAuthorship W1991468086A5037510528 @default.
• W1991468086 hasAuthorship W1991468086A5065850474 @default.
• W1991468086 hasAuthorship W1991468086A5076168662 @default.
• W1991468086 hasAuthorship W1991468086A5089156735 @default.
• W1991468086 hasConcept C112705442 @default.
• W1991468086 hasConcept C126322002 @default.
• W1991468086 hasConcept C134018914 @default.
• W1991468086 hasConcept C140793950 @default.
• W1991468086 hasConcept C142724271 @default.
• W1991468086 hasConcept C185592680 @default.
• W1991468086 hasConcept C2776344049 @default.
• W1991468086 hasConcept C2776366702 @default.
• W1991468086 hasConcept C2776390293 @default.
• W1991468086 hasConcept C2777226302 @default.
• W1991468086 hasConcept C2778512257 @default.
• W1991468086 hasConcept C2779314605 @default.
• W1991468086 hasConcept C2779720271 @default.
• W1991468086 hasConcept C2779906673 @default.
• W1991468086 hasConcept C43617362 @default.
• W1991468086 hasConcept C501593827 @default.
• W1991468086 hasConcept C55493867 @default.
• W1991468086 hasConcept C71924100 @default.
• W1991468086 hasConcept C86803240 @default.
• W1991468086 hasConceptScore W1991468086C112705442 @default.
• W1991468086 hasConceptScore W1991468086C126322002 @default.
• W1991468086 hasConceptScore W1991468086C134018914 @default.
• W1991468086 hasConceptScore W1991468086C140793950 @default.
• W1991468086 hasConceptScore W1991468086C142724271 @default.
• W1991468086 hasConceptScore W1991468086C185592680 @default.
• W1991468086 hasConceptScore W1991468086C2776344049 @default.
• W1991468086 hasConceptScore W1991468086C2776366702 @default.
• W1991468086 hasConceptScore W1991468086C2776390293 @default.
• W1991468086 hasConceptScore W1991468086C2777226302 @default.
• W1991468086 hasConceptScore W1991468086C2778512257 @default.
• W1991468086 hasConceptScore W1991468086C2779314605 @default.
• W1991468086 hasConceptScore W1991468086C2779720271 @default.
• W1991468086 hasConceptScore W1991468086C2779906673 @default.
• W1991468086 hasConceptScore W1991468086C43617362 @default.
• W1991468086 hasConceptScore W1991468086C501593827 @default.
• W1991468086 hasConceptScore W1991468086C55493867 @default.
• W1991468086 hasConceptScore W1991468086C71924100 @default.
• W1991468086 hasConceptScore W1991468086C86803240 @default.
• W1991468086 hasIssue "1-2" @default.
• W1991468086 hasLocation W19914680861 @default.
• W1991468086 hasLocation W19914680862 @default.
• W1991468086 hasOpenAccess W1991468086 @default.

• next