FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991469729> ?p ?o ?g. }

• W1991469729 endingPage "498" @default.
• W1991469729 startingPage "485" @default.
• W1991469729 abstract "Autism is diagnosed on the basis of behavioral manifestations, but its biomarkers are not well defined. A strong gender bias typifying autism (it is 4–5 times more prevalent in males) suggests involvement of steroid hormones in autism pathobiology. In order to evaluate the potential roles of such hormones in autism, we compared the salivary levels of 22 steroids in prepubertal autistic male and female children from two age groups (3–4 and 7–9 years old) with those in healthy controls. The steroids were analyzed using gas chromatography–mass spectrometry and radioimmunoassay. Statistical analysis (ANOVA) revealed that autistic children had significantly higher salivary concentrations of many steroid hormones (both C21 and C19) than control children. These anomalies were more prominent in older autistic children and in boys. The levels of androgens (androstenediol, dehydroepiandrosterone, androsterone and their polar conjugates) were especially increased, indicative of precocious adrenarche and predictive of early puberty. The concentrations of the steroid precursor, pregnenolone, and of several pregnanolones were also higher in autistic than in healthy children, but cortisol levels were not different. Some steroids, whose levels are raised in autism (allopregnanolone, androsterone, pregnenolone, dehydroepiandrosterone and their sulfate conjugates) are neuroactive and modulate GABA, glutamate, and opioid neurotransmission, affecting brain development and functioning. These steroids may contribute to autism pathobiology and symptoms such as elevated anxiety, sleep disturbances, sensory deficits, and stereotypies among others. We suggest that salivary levels of selected steroids may serve as biomarkers of autism pathology useful for monitoring the progress of therapy." @default.
• W1991469729 created "2016-06-24" @default.
• W1991469729 creator A5007763289 @default.
• W1991469729 creator A5022482433 @default.
• W1991469729 creator A5025299751 @default.
• W1991469729 creator A5035392158 @default.
• W1991469729 creator A5039430105 @default.
• W1991469729 creator A5042700884 @default.
• W1991469729 creator A5081261892 @default.
• W1991469729 date "2013-09-17" @default.
• W1991469729 modified "2023-09-25" @default.
• W1991469729 title "Marked elevation of adrenal steroids, especially androgens, in saliva of prepubertal autistic children" @default.
• W1991469729 cites W1486681857 @default.
• W1991469729 cites W1486857317 @default.
• W1991469729 cites W1534702329 @default.
• W1991469729 cites W1565550930 @default.
• W1991469729 cites W175549756 @default.
• W1991469729 cites W1906758352 @default.
• W1991469729 cites W1974944534 @default.
• W1991469729 cites W1975616007 @default.
• W1991469729 cites W1984917548 @default.
• W1991469729 cites W1995878014 @default.
• W1991469729 cites W1996087940 @default.
• W1991469729 cites W2001309356 @default.
• W1991469729 cites W2004042998 @default.
• W1991469729 cites W2006442321 @default.
• W1991469729 cites W2012618926 @default.
• W1991469729 cites W2026473386 @default.
• W1991469729 cites W2029774471 @default.
• W1991469729 cites W2031414482 @default.
• W1991469729 cites W2039976991 @default.
• W1991469729 cites W2040669748 @default.
• W1991469729 cites W2041566693 @default.
• W1991469729 cites W2047844916 @default.
• W1991469729 cites W2060422855 @default.
• W1991469729 cites W2071436913 @default.
• W1991469729 cites W2071731410 @default.
• W1991469729 cites W2078771459 @default.
• W1991469729 cites W2079739964 @default.
• W1991469729 cites W2083447043 @default.
• W1991469729 cites W2086740582 @default.
• W1991469729 cites W2086838075 @default.
• W1991469729 cites W2088477098 @default.
• W1991469729 cites W2089020381 @default.
• W1991469729 cites W2089401366 @default.
• W1991469729 cites W2091572596 @default.
• W1991469729 cites W2095619793 @default.
• W1991469729 cites W2095959713 @default.
• W1991469729 cites W2098251401 @default.
• W1991469729 cites W2110827855 @default.
• W1991469729 cites W2119315359 @default.
• W1991469729 cites W2124859267 @default.
• W1991469729 cites W2138758331 @default.
• W1991469729 cites W2140504392 @default.
• W1991469729 cites W2147720692 @default.
• W1991469729 cites W2150478567 @default.
• W1991469729 cites W2161063401 @default.
• W1991469729 cites W2162037295 @default.
• W1991469729 cites W2162109306 @default.
• W1991469729 cites W2529230938 @default.
• W1991469729 doi "https://doi.org/10.1007/s00787-013-0472-0" @default.
• W1991469729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4042015" @default.
• W1991469729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24043498" @default.
• W1991469729 hasPublicationYear "2013" @default.
• W1991469729 type Work @default.
• W1991469729 sameAs 1991469729 @default.
• W1991469729 citedByCount "50" @default.
• W1991469729 countsByYear W19914697292015 @default.
• W1991469729 countsByYear W19914697292016 @default.
• W1991469729 countsByYear W19914697292017 @default.
• W1991469729 countsByYear W19914697292018 @default.
• W1991469729 countsByYear W19914697292019 @default.
• W1991469729 countsByYear W19914697292020 @default.
• W1991469729 countsByYear W19914697292021 @default.
• W1991469729 countsByYear W19914697292022 @default.
• W1991469729 countsByYear W19914697292023 @default.
• W1991469729 crossrefType "journal-article" @default.
• W1991469729 hasAuthorship W1991469729A5007763289 @default.
• W1991469729 hasAuthorship W1991469729A5022482433 @default.
• W1991469729 hasAuthorship W1991469729A5025299751 @default.
• W1991469729 hasAuthorship W1991469729A5035392158 @default.
• W1991469729 hasAuthorship W1991469729A5039430105 @default.
• W1991469729 hasAuthorship W1991469729A5042700884 @default.
• W1991469729 hasAuthorship W1991469729A5081261892 @default.
• W1991469729 hasBestOaLocation W19914697291 @default.
• W1991469729 hasConcept C118552586 @default.
• W1991469729 hasConcept C121207290 @default.
• W1991469729 hasConcept C126322002 @default.
• W1991469729 hasConcept C134018914 @default.
• W1991469729 hasConcept C15744967 @default.
• W1991469729 hasConcept C168258287 @default.
• W1991469729 hasConcept C170493617 @default.
• W1991469729 hasConcept C205778803 @default.
• W1991469729 hasConcept C2776992908 @default.
• W1991469729 hasConcept C2777911890 @default.
• W1991469729 hasConcept C2778182776 @default.
• W1991469729 hasConcept C2778338918 @default.
• W1991469729 hasConcept C2779279991 @default.

• next