FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991469830> ?p ?o ?g. }

• W1991469830 endingPage "167" @default.
• W1991469830 startingPage "159" @default.
• W1991469830 abstract "The mechanisms underlying the involvement of advanced glycation endproducts (AGEs) in diabetic atherosclerosis are not fully understood. The present study was designed to investigate whether intermediate-conductance Ca(2+)-activated K(+) channels (K(Ca)3.1 channels) are involved in migration and proliferation induced by AGEs in cultured rat vascular smooth muscle cells (VSMCs) using approaches of whole-cell patch voltage-clamp, cell proliferation and migration assay, and western blot analysis. It was found that the current density and protein level of K(Ca)3.1 channels were enhanced in cells incubated with AGE-BSA (bovine serum albumin), and the effects were reversed by co-incubation of AGE-BSA with anti-RAGE (anti-receptors of AGEs) antibody. The ERK1/2 inhibitors PD98059 and U0126, the P38-MAPK inhibitors SB203580 and SB202190, or the PI3K inhibitors LY294002 and wortmannin countered the K(Ca)3.1 channel expression by AGE-BSA. In addition, AGE-BAS increased cell migration and proliferation, and the effects were fully reversed with anti-RAGE antibody, the K(Ca)3.1 channel blocker TRAM-34, or K(Ca)3.1 small interfering RNA. These results demonstrate for the first time that AGEs-induced increase of migration and proliferation is related to the upregulation of K(Ca)3.1 channels in rat VMSCs, and the intracellular signals ERK1/2, P38-MAPK and PI3K are involved in the regulation of K(Ca)3.1 channel expression." @default.
• W1991469830 created "2016-06-24" @default.
• W1991469830 creator A5002430008 @default.
• W1991469830 creator A5003642180 @default.
• W1991469830 creator A5056803639 @default.
• W1991469830 creator A5076765345 @default.
• W1991469830 creator A5086669859 @default.
• W1991469830 date "2013-02-01" @default.
• W1991469830 modified "2023-10-17" @default.
• W1991469830 title "KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells" @default.
• W1991469830 cites W1483156553 @default.
• W1991469830 cites W1557732299 @default.
• W1991469830 cites W1575840121 @default.
• W1991469830 cites W1876744328 @default.
• W1991469830 cites W1966234811 @default.
• W1991469830 cites W1980558797 @default.
• W1991469830 cites W1985332887 @default.
• W1991469830 cites W1999684267 @default.
• W1991469830 cites W2013107306 @default.
• W1991469830 cites W2026908793 @default.
• W1991469830 cites W2029789771 @default.
• W1991469830 cites W2043601751 @default.
• W1991469830 cites W2049170890 @default.
• W1991469830 cites W2060331633 @default.
• W1991469830 cites W2067521616 @default.
• W1991469830 cites W2078195495 @default.
• W1991469830 cites W2094401453 @default.
• W1991469830 cites W2102048637 @default.
• W1991469830 cites W2108658249 @default.
• W1991469830 cites W2108964501 @default.
• W1991469830 cites W2113695378 @default.
• W1991469830 cites W2120833123 @default.
• W1991469830 cites W2129902595 @default.
• W1991469830 cites W2145478166 @default.
• W1991469830 cites W2146666237 @default.
• W1991469830 cites W2148715056 @default.
• W1991469830 cites W2149648512 @default.
• W1991469830 cites W2154750794 @default.
• W1991469830 cites W2155168389 @default.
• W1991469830 cites W2161876238 @default.
• W1991469830 cites W2164514432 @default.
• W1991469830 cites W4241103062 @default.
• W1991469830 doi "https://doi.org/10.1038/labinvest.2012.163" @default.
• W1991469830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23212096" @default.
• W1991469830 hasPublicationYear "2013" @default.
• W1991469830 type Work @default.
• W1991469830 sameAs 1991469830 @default.
• W1991469830 citedByCount "39" @default.
• W1991469830 countsByYear W19914698302013 @default.
• W1991469830 countsByYear W19914698302014 @default.
• W1991469830 countsByYear W19914698302015 @default.
• W1991469830 countsByYear W19914698302016 @default.
• W1991469830 countsByYear W19914698302017 @default.
• W1991469830 countsByYear W19914698302018 @default.
• W1991469830 countsByYear W19914698302019 @default.
• W1991469830 countsByYear W19914698302020 @default.
• W1991469830 countsByYear W19914698302021 @default.
• W1991469830 countsByYear W19914698302022 @default.
• W1991469830 countsByYear W19914698302023 @default.
• W1991469830 crossrefType "journal-article" @default.
• W1991469830 hasAuthorship W1991469830A5002430008 @default.
• W1991469830 hasAuthorship W1991469830A5003642180 @default.
• W1991469830 hasAuthorship W1991469830A5056803639 @default.
• W1991469830 hasAuthorship W1991469830A5076765345 @default.
• W1991469830 hasAuthorship W1991469830A5086669859 @default.
• W1991469830 hasBestOaLocation W19914698301 @default.
• W1991469830 hasConcept C104317684 @default.
• W1991469830 hasConcept C126322002 @default.
• W1991469830 hasConcept C134018914 @default.
• W1991469830 hasConcept C147944092 @default.
• W1991469830 hasConcept C153911025 @default.
• W1991469830 hasConcept C170493617 @default.
• W1991469830 hasConcept C185592680 @default.
• W1991469830 hasConcept C2776415932 @default.
• W1991469830 hasConcept C2776912716 @default.
• W1991469830 hasConcept C2778308172 @default.
• W1991469830 hasConcept C2779395532 @default.
• W1991469830 hasConcept C2992686903 @default.
• W1991469830 hasConcept C51551487 @default.
• W1991469830 hasConcept C55493867 @default.
• W1991469830 hasConcept C57074206 @default.
• W1991469830 hasConcept C62112901 @default.
• W1991469830 hasConcept C62478195 @default.
• W1991469830 hasConcept C71924100 @default.
• W1991469830 hasConcept C86554907 @default.
• W1991469830 hasConcept C86803240 @default.
• W1991469830 hasConcept C95444343 @default.
• W1991469830 hasConceptScore W1991469830C104317684 @default.
• W1991469830 hasConceptScore W1991469830C126322002 @default.
• W1991469830 hasConceptScore W1991469830C134018914 @default.
• W1991469830 hasConceptScore W1991469830C147944092 @default.
• W1991469830 hasConceptScore W1991469830C153911025 @default.
• W1991469830 hasConceptScore W1991469830C170493617 @default.
• W1991469830 hasConceptScore W1991469830C185592680 @default.
• W1991469830 hasConceptScore W1991469830C2776415932 @default.
• W1991469830 hasConceptScore W1991469830C2776912716 @default.
• W1991469830 hasConceptScore W1991469830C2778308172 @default.
• W1991469830 hasConceptScore W1991469830C2779395532 @default.

• next