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- W1991470194 abstract "Background:Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness among older adults in the United States and throughout the developed world. Etiological research implicates both genetic and environmental components. Our prior genome scan in 511 affected sib-pairs and other relative pairs identified significant or suggestive linkage signals on chromosomes 1, 2, 3, 6, 8, 10, 12, 16, and 22. Purpose:To search for genetic loci for AMD using the extremely discordant sib-pair (EDSP) method of linkage analysis, which until now has never been applied to the study of AMD. Methods: The EDSP method is a more powerful approach than standard methods which rely on relative pairs selected at random or pairs concordant for the phenotype. The EDSP approach has also been characterized as the only design that is uniformly powerful in nearly all genetic situations. Thus, substantial reductions in sample size can be achieved. Study population:The study sample for analysis included 110 ..." @default.
- W1991470194 created "2016-06-24" @default.
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- W1991470194 date "2005-01-01" @default.
- W1991470194 modified "2023-10-14" @default.
- W1991470194 title "A Discordant Sib-Pair Linkage Analysis of Age-Related Macular Degeneration" @default.
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- W1991470194 doi "https://doi.org/10.1080/13816810490967944" @default.
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