Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991470338> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1991470338 endingPage "107" @default.
- W1991470338 startingPage "99" @default.
- W1991470338 abstract "The effect of organic solvents on the degradation kinetics, products and mechanisms of Moexipril (1) was investigated at 25°C. Like those observed in aqueous solution, the degradation kinetics leading to the diketopiperazine (2) and hydrolysis product (3) in mixed solvents were found to be pseudo-first-order. Added organic solvent, however, produced a dramatic effect on the rate and product ratio of the degradation. Thus, the hydrolysis process (k3) was suppressed in solvents with high organic content. The two water or neutral catalyzed cyclizaation processes (k1 and k2) responsible for the diketopiperazine formation, on the other hand, were enhanced by the addition of organic solvent; a maximum increase of 5.5 and 29-fold for k1 and k2, respectively, was observed in 75–90% ethanol solutions. Attempts were made to rationalize such rate enhancement through changes in solvation energy, pKa values of 1 and equilibrium constants of the intermediates with added organics. The application of the results to some of the formulation problems is discussed." @default.
- W1991470338 created "2016-06-24" @default.
- W1991470338 creator A5004226989 @default.
- W1991470338 creator A5065686845 @default.
- W1991470338 date "1990-04-01" @default.
- W1991470338 modified "2023-09-23" @default.
- W1991470338 title "A profound solvent effect on the diketopiperazine formation of the new dipeptide angiotensin-converting enzyme inhibitor, Moexipril" @default.
- W1991470338 cites W1496269337 @default.
- W1991470338 cites W1585630182 @default.
- W1991470338 cites W1976803648 @default.
- W1991470338 cites W1981060781 @default.
- W1991470338 cites W1985090509 @default.
- W1991470338 cites W2000098259 @default.
- W1991470338 cites W2042186844 @default.
- W1991470338 cites W2044955863 @default.
- W1991470338 cites W2051629630 @default.
- W1991470338 cites W2066681698 @default.
- W1991470338 cites W2071961454 @default.
- W1991470338 cites W2075813496 @default.
- W1991470338 cites W2094489697 @default.
- W1991470338 cites W2167083016 @default.
- W1991470338 cites W2949285980 @default.
- W1991470338 doi "https://doi.org/10.1016/0378-5173(90)90295-f" @default.
- W1991470338 hasPublicationYear "1990" @default.
- W1991470338 type Work @default.
- W1991470338 sameAs 1991470338 @default.
- W1991470338 citedByCount "16" @default.
- W1991470338 countsByYear W19914703382012 @default.
- W1991470338 countsByYear W19914703382013 @default.
- W1991470338 countsByYear W19914703382014 @default.
- W1991470338 countsByYear W19914703382015 @default.
- W1991470338 countsByYear W19914703382020 @default.
- W1991470338 crossrefType "journal-article" @default.
- W1991470338 hasAuthorship W1991470338A5004226989 @default.
- W1991470338 hasAuthorship W1991470338A5065686845 @default.
- W1991470338 hasConcept C121332964 @default.
- W1991470338 hasConcept C132439834 @default.
- W1991470338 hasConcept C148093993 @default.
- W1991470338 hasConcept C148898269 @default.
- W1991470338 hasConcept C178790620 @default.
- W1991470338 hasConcept C184651966 @default.
- W1991470338 hasConcept C185592680 @default.
- W1991470338 hasConcept C2779138802 @default.
- W1991470338 hasConcept C2780161600 @default.
- W1991470338 hasConcept C2780471494 @default.
- W1991470338 hasConcept C515207424 @default.
- W1991470338 hasConcept C55493867 @default.
- W1991470338 hasConcept C62520636 @default.
- W1991470338 hasConcept C93391505 @default.
- W1991470338 hasConcept C94412978 @default.
- W1991470338 hasConceptScore W1991470338C121332964 @default.
- W1991470338 hasConceptScore W1991470338C132439834 @default.
- W1991470338 hasConceptScore W1991470338C148093993 @default.
- W1991470338 hasConceptScore W1991470338C148898269 @default.
- W1991470338 hasConceptScore W1991470338C178790620 @default.
- W1991470338 hasConceptScore W1991470338C184651966 @default.
- W1991470338 hasConceptScore W1991470338C185592680 @default.
- W1991470338 hasConceptScore W1991470338C2779138802 @default.
- W1991470338 hasConceptScore W1991470338C2780161600 @default.
- W1991470338 hasConceptScore W1991470338C2780471494 @default.
- W1991470338 hasConceptScore W1991470338C515207424 @default.
- W1991470338 hasConceptScore W1991470338C55493867 @default.
- W1991470338 hasConceptScore W1991470338C62520636 @default.
- W1991470338 hasConceptScore W1991470338C93391505 @default.
- W1991470338 hasConceptScore W1991470338C94412978 @default.
- W1991470338 hasIssue "2" @default.
- W1991470338 hasLocation W19914703381 @default.
- W1991470338 hasOpenAccess W1991470338 @default.
- W1991470338 hasPrimaryLocation W19914703381 @default.
- W1991470338 hasRelatedWork W1986019010 @default.
- W1991470338 hasRelatedWork W1989940360 @default.
- W1991470338 hasRelatedWork W2032775470 @default.
- W1991470338 hasRelatedWork W2050186274 @default.
- W1991470338 hasRelatedWork W2060405207 @default.
- W1991470338 hasRelatedWork W2557747266 @default.
- W1991470338 hasRelatedWork W3006287043 @default.
- W1991470338 hasRelatedWork W3006428522 @default.
- W1991470338 hasRelatedWork W908168109 @default.
- W1991470338 hasRelatedWork W2001587174 @default.
- W1991470338 hasVolume "60" @default.
- W1991470338 isParatext "false" @default.
- W1991470338 isRetracted "false" @default.
- W1991470338 magId "1991470338" @default.
- W1991470338 workType "article" @default.