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• W1991480977 abstract "There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3 mm and bulk densities ranging from 0.11 to 0.23 g/cm(3). These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria." @default.
• W1991480977 created "2016-06-24" @default.
• W1991480977 creator A5069035256 @default.
• W1991480977 creator A5077234561 @default.
• W1991480977 date "2013-06-24" @default.
• W1991480977 modified "2023-09-26" @default.
• W1991480977 title "Preparation and characterisation of gastroretentive alginate beads for targeting<i>H. pylori</i>" @default.
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• W1991480977 doi "https://doi.org/10.3109/02652048.2013.805840" @default.
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