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- W1991486695 abstract "Abstract: Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor metabolizers (PM) whereas 279 subjects were classified as extensive metaboliz–ers (EM). The metabolic ratio (MR) between sparteine and 2– and 5–dehydrosparteine (% of dose) in 12 hrs urine ranged from 0.11–12.6 in EM and from 30–394 in PM. Urinary excretion of 2– and 5–dehydrosparteine also discriminated between PM and EM. Age, sex, and smoking habits did not influence the MR. This study confirms that sparteine is a useful probe drug in pharmacogenetic investigations" @default.
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- W1991486695 date "2009-03-13" @default.
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- W1991486695 title "Sparteine Oxidation Polymorphism in Denmark" @default.
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- W1991486695 doi "https://doi.org/10.1111/j.1600-0773.1985.tb00058.x" @default.
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