FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991487667> ?p ?o ?g. }

• W1991487667 endingPage "345" @default.
• W1991487667 startingPage "339" @default.
• W1991487667 abstract "The host response to Gram-negative infection includes the elaboration of numerous proinflammatory agents, including tumor necrosis factor α (TNFα) and nitric oxide (NO). A component of the hepatic response to infection is an elevation in serum lipids, the so-called “lipemia of sepsis,” which results from the increased production of triglyceride (TG)-rich lipoproteins by the liver. We have postulated that these lipoproteins are components of a nonadaptive, innate immune response to endotoxin [lipopolysaccharide (LPS)] and have previously demonstrated the capacity of TG-rich lipoproteins to protect against endotoxicity in rodent models of sepsis. Herein we report the capacity of a high-fructose diet to protect against LPS, most likely by inducing high circulating levels of endogenous TG-rich lipoproteins. The protective phenotype included the increased production of NO by hepatic endothelial cells. Rats, made hypertriglyceridemic by fructose feeding, experienced decreased LPS-induced mortality (P< 0.03) and systemic TNFα levels (P< 0.05) as compared with normolipidemic (chow-fed) controls. The increased survival was associated with elevated levels of inducible NO synthase (NOS2) mRNA levels and NO production (82 ± 26 vs 3 ± 3 nmol nitrite/106cells,P< 0.001) by hepatic endothelial cells. Nonselective NOS inhibitors reversed the protective phenotypein vivoand readily decreased NO production by cultured endothelial cells from hypertriglyceridemic ratsin vitro.This study suggests that a high-fructose diet can protect against endotoxicity in part through induction of endogenous TG-rich lipoproteins and hepatic endothelial cell NO production. This is the first report of diet-induced hyperlipoproteinemia and subsequent protection against endotoxemia." @default.
• W1991487667 created "2016-06-24" @default.
• W1991487667 creator A5006835537 @default.
• W1991487667 creator A5043650697 @default.
• W1991487667 creator A5043752774 @default.
• W1991487667 creator A5066421476 @default.
• W1991487667 date "1999-04-01" @default.
• W1991487667 modified "2023-10-15" @default.
• W1991487667 title "Diet-Induced Protection against Lipopolysaccharide Includes Increased Hepatic NO Production" @default.
• W1991487667 cites W1607247330 @default.
• W1991487667 cites W1881872968 @default.
• W1991487667 cites W1945942263 @default.
• W1991487667 cites W1964960789 @default.
• W1991487667 cites W1968165732 @default.
• W1991487667 cites W1969549400 @default.
• W1991487667 cites W1974550614 @default.
• W1991487667 cites W1989961245 @default.
• W1991487667 cites W1990606879 @default.
• W1991487667 cites W1990802251 @default.
• W1991487667 cites W1996642278 @default.
• W1991487667 cites W2002069556 @default.
• W1991487667 cites W2004343006 @default.
• W1991487667 cites W2007681588 @default.
• W1991487667 cites W2036689136 @default.
• W1991487667 cites W2037597903 @default.
• W1991487667 cites W2046056432 @default.
• W1991487667 cites W2055406133 @default.
• W1991487667 cites W2064980105 @default.
• W1991487667 cites W2069030702 @default.
• W1991487667 cites W2069536567 @default.
• W1991487667 cites W2078119356 @default.
• W1991487667 cites W2084750391 @default.
• W1991487667 cites W2086109463 @default.
• W1991487667 cites W2093784230 @default.
• W1991487667 cites W2097310310 @default.
• W1991487667 cites W2102915331 @default.
• W1991487667 cites W2121390857 @default.
• W1991487667 cites W2132458195 @default.
• W1991487667 cites W2134215776 @default.
• W1991487667 cites W2137591851 @default.
• W1991487667 cites W2140846631 @default.
• W1991487667 cites W2147923435 @default.
• W1991487667 cites W2150451398 @default.
• W1991487667 cites W2158878726 @default.
• W1991487667 cites W2159420204 @default.
• W1991487667 doi "https://doi.org/10.1006/jsre.1999.5570" @default.
• W1991487667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10090849" @default.
• W1991487667 hasPublicationYear "1999" @default.
• W1991487667 type Work @default.
• W1991487667 sameAs 1991487667 @default.
• W1991487667 citedByCount "13" @default.
• W1991487667 countsByYear W19914876672012 @default.
• W1991487667 countsByYear W19914876672021 @default.
• W1991487667 crossrefType "journal-article" @default.
• W1991487667 hasAuthorship W1991487667A5006835537 @default.
• W1991487667 hasAuthorship W1991487667A5043650697 @default.
• W1991487667 hasAuthorship W1991487667A5043752774 @default.
• W1991487667 hasAuthorship W1991487667A5066421476 @default.
• W1991487667 hasConcept C126322002 @default.
• W1991487667 hasConcept C134018914 @default.
• W1991487667 hasConcept C164027704 @default.
• W1991487667 hasConcept C16613235 @default.
• W1991487667 hasConcept C17991360 @default.
• W1991487667 hasConcept C203014093 @default.
• W1991487667 hasConcept C2776914184 @default.
• W1991487667 hasConcept C2777622882 @default.
• W1991487667 hasConcept C2778163477 @default.
• W1991487667 hasConcept C2778384902 @default.
• W1991487667 hasConcept C2778754761 @default.
• W1991487667 hasConcept C2778913445 @default.
• W1991487667 hasConcept C519581460 @default.
• W1991487667 hasConcept C71924100 @default.
• W1991487667 hasConcept C86803240 @default.
• W1991487667 hasConcept C8891405 @default.
• W1991487667 hasConceptScore W1991487667C126322002 @default.
• W1991487667 hasConceptScore W1991487667C134018914 @default.
• W1991487667 hasConceptScore W1991487667C164027704 @default.
• W1991487667 hasConceptScore W1991487667C16613235 @default.
• W1991487667 hasConceptScore W1991487667C17991360 @default.
• W1991487667 hasConceptScore W1991487667C203014093 @default.
• W1991487667 hasConceptScore W1991487667C2776914184 @default.
• W1991487667 hasConceptScore W1991487667C2777622882 @default.
• W1991487667 hasConceptScore W1991487667C2778163477 @default.
• W1991487667 hasConceptScore W1991487667C2778384902 @default.
• W1991487667 hasConceptScore W1991487667C2778754761 @default.
• W1991487667 hasConceptScore W1991487667C2778913445 @default.
• W1991487667 hasConceptScore W1991487667C519581460 @default.
• W1991487667 hasConceptScore W1991487667C71924100 @default.
• W1991487667 hasConceptScore W1991487667C86803240 @default.
• W1991487667 hasConceptScore W1991487667C8891405 @default.
• W1991487667 hasIssue "2" @default.
• W1991487667 hasLocation W19914876671 @default.
• W1991487667 hasLocation W19914876672 @default.
• W1991487667 hasOpenAccess W1991487667 @default.
• W1991487667 hasPrimaryLocation W19914876671 @default.
• W1991487667 hasRelatedWork W1968811274 @default.
• W1991487667 hasRelatedWork W1992848314 @default.
• W1991487667 hasRelatedWork W2015667478 @default.

• next