Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991492743> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1991492743 endingPage "6914" @default.
- W1991492743 startingPage "6914" @default.
- W1991492743 abstract "Purpose.: Prior models of glaucoma filtration surgery assess bleb morphology, which does not always reflect function. Our aim is to establish a model that directly measures tissue hydraulic conductivity of postsurgical outflow in rabbit bleb capsules following experimental glaucoma filtration surgery. Methods.: Nine rabbits underwent insertion of a single-plate pediatric Molteno implant into the anterior chamber of their left eye. Right eyes were used as controls. The rabbits were then allocated to one of two groups. Group one had outflow measurements performed at 1 week after surgery (n = 5), and group two had measurements performed at 4 weeks (n = 4). Measurements were performed by cannulating the drainage tube ostium in situ with a needle attached to a pressure transducer and a fluid column at 15 mm Hg. The drop in the fluid column was measured every minute for 5 minutes. For the control eyes (n = 6), the anterior chamber of the unoperated fellow eye was cannulated. Animals were euthanized with the implant and its surrounding capsule dissected and fixed in 4% paraformaldehyde, and embedded in paraffin before 6-μm sections were cut for histologic staining. Results.: By 7 days after surgery, tube outflow was 0.117 ± 0.036 μL/min/mm Hg at 15 mm Hg (mean ± SEM), whereas at 28 days, it was 0.009 ± 0.003 μL/min/mm Hg. Control eyes had an outflow of 0.136 ± 0.007 μL/min/mm Hg (P = 0.004, one-way ANOVA). Hematoxylin and eosin staining demonstrated a thinner and looser arrangement of collagenous tissue in the capsules at 1 week compared with that at 4 weeks, which had thicker and more densely arranged collagen. Conclusions.: We describe a new model to directly measure hydraulic conductivity in a rabbit glaucoma surgery implant model. The principal physiologic endpoint of glaucoma surgery can be reliably quantified and consistently measured with this model. At 28 days post glaucoma filtration surgery, a rabbit bleb capsule has significantly reduced tissue hydraulic conductivity, in line with loss of implant outflow facility, and increased thickness and density of fibrous encapsulation." @default.
- W1991492743 created "2016-06-24" @default.
- W1991492743 creator A5000833127 @default.
- W1991492743 creator A5005036807 @default.
- W1991492743 creator A5016303999 @default.
- W1991492743 creator A5046888853 @default.
- W1991492743 creator A5050094020 @default.
- W1991492743 creator A5062571550 @default.
- W1991492743 creator A5070047765 @default.
- W1991492743 creator A5074726997 @default.
- W1991492743 creator A5080456079 @default.
- W1991492743 date "2012-10-05" @default.
- W1991492743 modified "2023-09-27" @default.
- W1991492743 title "A Model to Measure Fluid Outflow in Rabbit Capsules Post Glaucoma Implant Surgery" @default.
- W1991492743 cites W112863963 @default.
- W1991492743 cites W1559512332 @default.
- W1991492743 cites W1977024993 @default.
- W1991492743 cites W1980153450 @default.
- W1991492743 cites W1986280052 @default.
- W1991492743 cites W1986853442 @default.
- W1991492743 cites W2022264363 @default.
- W1991492743 cites W2022951544 @default.
- W1991492743 cites W2027056918 @default.
- W1991492743 cites W2045383913 @default.
- W1991492743 cites W2046270491 @default.
- W1991492743 cites W2116129544 @default.
- W1991492743 cites W2168531200 @default.
- W1991492743 doi "https://doi.org/10.1167/iovs.12-10438" @default.
- W1991492743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22956615" @default.
- W1991492743 hasPublicationYear "2012" @default.
- W1991492743 type Work @default.
- W1991492743 sameAs 1991492743 @default.
- W1991492743 citedByCount "11" @default.
- W1991492743 countsByYear W19914927432014 @default.
- W1991492743 countsByYear W19914927432015 @default.
- W1991492743 countsByYear W19914927432016 @default.
- W1991492743 countsByYear W19914927432019 @default.
- W1991492743 countsByYear W19914927432020 @default.
- W1991492743 countsByYear W19914927432022 @default.
- W1991492743 crossrefType "journal-article" @default.
- W1991492743 hasAuthorship W1991492743A5000833127 @default.
- W1991492743 hasAuthorship W1991492743A5005036807 @default.
- W1991492743 hasAuthorship W1991492743A5016303999 @default.
- W1991492743 hasAuthorship W1991492743A5046888853 @default.
- W1991492743 hasAuthorship W1991492743A5050094020 @default.
- W1991492743 hasAuthorship W1991492743A5062571550 @default.
- W1991492743 hasAuthorship W1991492743A5070047765 @default.
- W1991492743 hasAuthorship W1991492743A5074726997 @default.
- W1991492743 hasAuthorship W1991492743A5080456079 @default.
- W1991492743 hasConcept C105702510 @default.
- W1991492743 hasConcept C118487528 @default.
- W1991492743 hasConcept C125473707 @default.
- W1991492743 hasConcept C141071460 @default.
- W1991492743 hasConcept C142724271 @default.
- W1991492743 hasConcept C2776228307 @default.
- W1991492743 hasConcept C2777824320 @default.
- W1991492743 hasConcept C2778527774 @default.
- W1991492743 hasConcept C2778930955 @default.
- W1991492743 hasConcept C2781092963 @default.
- W1991492743 hasConcept C2781121420 @default.
- W1991492743 hasConcept C2781411149 @default.
- W1991492743 hasConcept C71924100 @default.
- W1991492743 hasConcept C74864618 @default.
- W1991492743 hasConceptScore W1991492743C105702510 @default.
- W1991492743 hasConceptScore W1991492743C118487528 @default.
- W1991492743 hasConceptScore W1991492743C125473707 @default.
- W1991492743 hasConceptScore W1991492743C141071460 @default.
- W1991492743 hasConceptScore W1991492743C142724271 @default.
- W1991492743 hasConceptScore W1991492743C2776228307 @default.
- W1991492743 hasConceptScore W1991492743C2777824320 @default.
- W1991492743 hasConceptScore W1991492743C2778527774 @default.
- W1991492743 hasConceptScore W1991492743C2778930955 @default.
- W1991492743 hasConceptScore W1991492743C2781092963 @default.
- W1991492743 hasConceptScore W1991492743C2781121420 @default.
- W1991492743 hasConceptScore W1991492743C2781411149 @default.
- W1991492743 hasConceptScore W1991492743C71924100 @default.
- W1991492743 hasConceptScore W1991492743C74864618 @default.
- W1991492743 hasIssue "11" @default.
- W1991492743 hasLocation W19914927431 @default.
- W1991492743 hasLocation W19914927432 @default.
- W1991492743 hasOpenAccess W1991492743 @default.
- W1991492743 hasPrimaryLocation W19914927431 @default.
- W1991492743 hasRelatedWork W1511738529 @default.
- W1991492743 hasRelatedWork W1983251625 @default.
- W1991492743 hasRelatedWork W2013915487 @default.
- W1991492743 hasRelatedWork W2026300329 @default.
- W1991492743 hasRelatedWork W2036350030 @default.
- W1991492743 hasRelatedWork W2085327695 @default.
- W1991492743 hasRelatedWork W2310463995 @default.
- W1991492743 hasRelatedWork W2328756306 @default.
- W1991492743 hasRelatedWork W3176735208 @default.
- W1991492743 hasRelatedWork W4375861827 @default.
- W1991492743 hasVolume "53" @default.
- W1991492743 isParatext "false" @default.
- W1991492743 isRetracted "false" @default.
- W1991492743 magId "1991492743" @default.
- W1991492743 workType "article" @default.