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- W1991496314 abstract "Tetrafluorinated phenylalanines were incorporated into villin headpiece subdomain HP35, and their energetic contribution to protein stability was evaluated. In comparison to pentafluoro-phenylalanines, HP35 variants harboring tetrafluorinated phenylalanines exhibit increased thermal and thermodynamic stability by a large margin. The favorable stabilization is attributed to the electrostatic ArH···π interactions retained and strengthened by the highly, but not fully, fluorinated aromatic rings." @default.
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- W1991496314 date "2008-12-09" @default.
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- W1991496314 title "Expanding the Fluorous Arsenal: Tetrafluorinated Phenylalanines for Protein Design" @default.
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- W1991496314 doi "https://doi.org/10.1021/ja8062309" @default.
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