FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991497223> ?p ?o ?g. }

• W1991497223 endingPage "118" @default.
• W1991497223 startingPage "109" @default.
• W1991497223 abstract "Selenium deficiency causes oxidative stress and impairs steroidogenesis in vitro. Leptin is closely related to the hypothalamo-pituitary-adrenal (HPA) axis. Leptin inhibits the HPA axis at the central level while corticosteroids have been shown to stimulate leptin secretion in most studies. We hypothesized that oxidative stress impairs adrenal steroidogenesis and decreases leptin production in vivo. The goal of this study was to investigate in rats the effects of selenium deficiency and oxidative stress on adrenal function and on leptin concentrations. Weanling rats were fed a selenium-deficient (Se-) or selenium-sufficient (Se+) diet for 4–10 weeks. Selenium deficiency caused a marked decrease in liver (≥ 99%) and adrenal (≥ 81%) glutathione peroxidase (GPx) activities. Selenium deficiency did not affect basal and short-term adrenocorticotropin (ACTH) stimulated corticosterone or leptin concentrations. In contrast, after long-term ACTH stimulation, selenium deficiency caused a doubling in adrenal isoprostane content and blunted the increase in corticosterone and leptin concentrations observed in Se+ animals. Plasma leptin concentrations were 50% lower in Se- compared to Se+ animals following long-term ACTH. Our results suggest that oxidative stress causes a decrease in circulating corticosterone in response to ACTH, and, as a consequence, a decrease in plasma leptin concentrations." @default.
• W1991497223 created "2016-06-24" @default.
• W1991497223 creator A5039693167 @default.
• W1991497223 creator A5060964519 @default.
• W1991497223 creator A5077812935 @default.
• W1991497223 date "2004-01-01" @default.
• W1991497223 modified "2023-10-17" @default.
• W1991497223 title "Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat" @default.
• W1991497223 cites W1513274162 @default.
• W1991497223 cites W1529714333 @default.
• W1991497223 cites W1529727688 @default.
• W1991497223 cites W1966597352 @default.
• W1991497223 cites W1967487924 @default.
• W1991497223 cites W1969492577 @default.
• W1991497223 cites W1971598438 @default.
• W1991497223 cites W1987003312 @default.
• W1991497223 cites W1994617028 @default.
• W1991497223 cites W1999010068 @default.
• W1991497223 cites W2007469012 @default.
• W1991497223 cites W2012902499 @default.
• W1991497223 cites W2021676727 @default.
• W1991497223 cites W2021883733 @default.
• W1991497223 cites W2029335231 @default.
• W1991497223 cites W2034810986 @default.
• W1991497223 cites W2035301458 @default.
• W1991497223 cites W2039490460 @default.
• W1991497223 cites W2043718040 @default.
• W1991497223 cites W2046922552 @default.
• W1991497223 cites W2052753565 @default.
• W1991497223 cites W2062724474 @default.
• W1991497223 cites W2065864773 @default.
• W1991497223 cites W2066217148 @default.
• W1991497223 cites W2068172765 @default.
• W1991497223 cites W2069224161 @default.
• W1991497223 cites W2076672539 @default.
• W1991497223 cites W2079441984 @default.
• W1991497223 cites W2084082896 @default.
• W1991497223 cites W2090665682 @default.
• W1991497223 cites W2093631184 @default.
• W1991497223 cites W2094237007 @default.
• W1991497223 cites W2098627686 @default.
• W1991497223 cites W2100352028 @default.
• W1991497223 cites W2145248244 @default.
• W1991497223 cites W2164926351 @default.
• W1991497223 cites W2334337188 @default.
• W1991497223 cites W334868265 @default.
• W1991497223 doi "https://doi.org/10.1002/biof.5520200205" @default.
• W1991497223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15322334" @default.
• W1991497223 hasPublicationYear "2004" @default.
• W1991497223 type Work @default.
• W1991497223 sameAs 1991497223 @default.
• W1991497223 citedByCount "22" @default.
• W1991497223 countsByYear W19914972232012 @default.
• W1991497223 countsByYear W19914972232014 @default.
• W1991497223 countsByYear W19914972232015 @default.
• W1991497223 countsByYear W19914972232017 @default.
• W1991497223 countsByYear W19914972232019 @default.
• W1991497223 countsByYear W19914972232020 @default.
• W1991497223 countsByYear W19914972232021 @default.
• W1991497223 countsByYear W19914972232022 @default.
• W1991497223 countsByYear W19914972232023 @default.
• W1991497223 crossrefType "journal-article" @default.
• W1991497223 hasAuthorship W1991497223A5039693167 @default.
• W1991497223 hasAuthorship W1991497223A5060964519 @default.
• W1991497223 hasAuthorship W1991497223A5077812935 @default.
• W1991497223 hasConcept C126322002 @default.
• W1991497223 hasConcept C134018914 @default.
• W1991497223 hasConcept C178790620 @default.
• W1991497223 hasConcept C185592680 @default.
• W1991497223 hasConcept C2775838275 @default.
• W1991497223 hasConcept C2776151105 @default.
• W1991497223 hasConcept C2778760513 @default.
• W1991497223 hasConcept C2779135701 @default.
• W1991497223 hasConcept C2780352252 @default.
• W1991497223 hasConcept C2780546910 @default.
• W1991497223 hasConcept C2780613262 @default.
• W1991497223 hasConcept C511355011 @default.
• W1991497223 hasConcept C553756173 @default.
• W1991497223 hasConcept C71315377 @default.
• W1991497223 hasConcept C71924100 @default.
• W1991497223 hasConcept C86803240 @default.
• W1991497223 hasConceptScore W1991497223C126322002 @default.
• W1991497223 hasConceptScore W1991497223C134018914 @default.
• W1991497223 hasConceptScore W1991497223C178790620 @default.
• W1991497223 hasConceptScore W1991497223C185592680 @default.
• W1991497223 hasConceptScore W1991497223C2775838275 @default.
• W1991497223 hasConceptScore W1991497223C2776151105 @default.
• W1991497223 hasConceptScore W1991497223C2778760513 @default.
• W1991497223 hasConceptScore W1991497223C2779135701 @default.
• W1991497223 hasConceptScore W1991497223C2780352252 @default.
• W1991497223 hasConceptScore W1991497223C2780546910 @default.
• W1991497223 hasConceptScore W1991497223C2780613262 @default.
• W1991497223 hasConceptScore W1991497223C511355011 @default.
• W1991497223 hasConceptScore W1991497223C553756173 @default.
• W1991497223 hasConceptScore W1991497223C71315377 @default.
• W1991497223 hasConceptScore W1991497223C71924100 @default.
• W1991497223 hasConceptScore W1991497223C86803240 @default.
• W1991497223 hasIssue "2" @default.

• next