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- W1991497274 abstract "Plumbous ion has been shown to catalyze the degradation of RNA, and the effects of lead-catalyzed depolymerization on some of the functions of tRNA has been investigated. Exposure to Pb2+ brings about a rapid decrease but not a complete loss of amino acid acceptance capacity. The tRNA molecules responsible for this residual activity have not been degraded and represent a class of molecules that are resistant to Pb2+. The ratio of susceptible to resistant tRNA increases when the temperature is raised. The effect of varying the Pb2+ concentration was studied, and there is a threshold Pb2+ concentration below which the tRNA is not inactivated. The ability of Pb2+ depolymerized tRNA to bind to ribosomes in response to its appropriate codon is impaired to a greater extent than the ability of the tRNA to accept amino acids. The Pb2+ concentration at which binding capacity is lost is at least two orders of magnitude above the level at which protein synthesis is inhibited in mammalian erythroid cells." @default.
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- W1991497274 date "1972-08-01" @default.
- W1991497274 modified "2023-09-26" @default.
- W1991497274 title "Effects of plumbous ion on some functions of transfer RNA" @default.
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- W1991497274 doi "https://doi.org/10.1016/0009-2797(72)90054-3" @default.
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