FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991499616> ?p ?o ?g. }

• W1991499616 endingPage "1079" @default.
• W1991499616 startingPage "1065" @default.
• W1991499616 abstract "PKC-theta (PKC-θ), a member of the novel protein kinase C family (nPKC), regulates a wide variety of functions in the periphery. However, its presence and role in the CNS has remained largely unknown. Recently, we demonstrated the presence of PKC-θ in the arcuate hypothalamic nucleus (ARC) and knockdown of PKC-θ from the ARC protected mice from developing diet-induced obesity. Another isoform of the nPKC group, PKC-delta (PKC-δ), is expressed in several non-hypothalamic brain sites including the thalamus and hippocampus. Although PKC-δ has been implicated in regulating hypothalamic glucose homeostasis, its distribution in the hypothalamus has not previously been described. In the current study, we used immunohistochemistry to examine the distribution of PKC-θ and -δ immunoreactivity in rat and mouse hypothalamus. We found PKC-θ immunoreactive neurons in several hypothalamic nuclei including the ARC, lateral hypothalamic area, perifornical area and tuberomammillary nucleus. PKC-δ immunoreactive neurons were found in the paraventricular and supraoptic nuclei. Double-label immunohistochemisty in mice expressing green fluorescent protein either with the long form of leptin receptor (LepR-b) or in orexin (ORX) neurons indicated that PKC-θ is highly colocalized in lateral hypothalamic ORX neurons but not in lateral hypothalamic LepR-b neurons. Double-label immunohistochemistry in oxytocin-enhanced yellow fluorescent protein mice or arginine vasopressin-enhanced green fluorescent protein (AVP-EGFP) transgenic rats revealed a high degree of colocalization of PKC-δ within paraventricular and supraoptic oxytocin neurons but not the vasopressinergic neurons. We conclude that PKC-θ and -δ are expressed in different hypothalamic neuronal populations." @default.
• W1991499616 created "2016-06-24" @default.
• W1991499616 creator A5007166081 @default.
• W1991499616 creator A5010150031 @default.
• W1991499616 creator A5012904065 @default.
• W1991499616 creator A5024782501 @default.
• W1991499616 creator A5044286863 @default.
• W1991499616 creator A5047861160 @default.
• W1991499616 creator A5056677109 @default.
• W1991499616 creator A5066981475 @default.
• W1991499616 creator A5072202042 @default.
• W1991499616 creator A5085555680 @default.
• W1991499616 creator A5086067249 @default.
• W1991499616 creator A5086183352 @default.
• W1991499616 creator A5091177547 @default.
• W1991499616 date "2010-11-01" @default.
• W1991499616 modified "2023-10-16" @default.
• W1991499616 title "Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus" @default.
• W1991499616 cites W1506453366 @default.
• W1991499616 cites W1561443084 @default.
• W1991499616 cites W1650137855 @default.
• W1991499616 cites W1919935630 @default.
• W1991499616 cites W1967578358 @default.
• W1991499616 cites W1969703123 @default.
• W1991499616 cites W1970429382 @default.
• W1991499616 cites W1974743256 @default.
• W1991499616 cites W1977742651 @default.
• W1991499616 cites W1978634351 @default.
• W1991499616 cites W1980492819 @default.
• W1991499616 cites W1981862978 @default.
• W1991499616 cites W1986633788 @default.
• W1991499616 cites W1989917638 @default.
• W1991499616 cites W1993353490 @default.
• W1991499616 cites W1993852948 @default.
• W1991499616 cites W1995491925 @default.
• W1991499616 cites W1999331745 @default.
• W1991499616 cites W2001660140 @default.
• W1991499616 cites W2001980298 @default.
• W1991499616 cites W2003590296 @default.
• W1991499616 cites W2008205503 @default.
• W1991499616 cites W2010142606 @default.
• W1991499616 cites W2012248446 @default.
• W1991499616 cites W2012311232 @default.
• W1991499616 cites W2013655437 @default.
• W1991499616 cites W2015571904 @default.
• W1991499616 cites W2018050193 @default.
• W1991499616 cites W2022017806 @default.
• W1991499616 cites W2024348439 @default.
• W1991499616 cites W2026971106 @default.
• W1991499616 cites W2027180375 @default.
• W1991499616 cites W2027259173 @default.
• W1991499616 cites W2027740042 @default.
• W1991499616 cites W2032609932 @default.
• W1991499616 cites W2035181200 @default.
• W1991499616 cites W2037945118 @default.
• W1991499616 cites W2040700968 @default.
• W1991499616 cites W2041677480 @default.
• W1991499616 cites W2042936589 @default.
• W1991499616 cites W2043394717 @default.
• W1991499616 cites W2044397943 @default.
• W1991499616 cites W2045807655 @default.
• W1991499616 cites W2055206305 @default.
• W1991499616 cites W2056501566 @default.
• W1991499616 cites W2062998121 @default.
• W1991499616 cites W2063524963 @default.
• W1991499616 cites W2072154498 @default.
• W1991499616 cites W2077944067 @default.
• W1991499616 cites W2079201209 @default.
• W1991499616 cites W2079437764 @default.
• W1991499616 cites W2086773481 @default.
• W1991499616 cites W2087949440 @default.
• W1991499616 cites W2091747262 @default.
• W1991499616 cites W2092670570 @default.
• W1991499616 cites W2099984791 @default.
• W1991499616 cites W2107337178 @default.
• W1991499616 cites W2115138453 @default.
• W1991499616 cites W2122301924 @default.
• W1991499616 cites W2124903886 @default.
• W1991499616 cites W2126589946 @default.
• W1991499616 cites W2129221666 @default.
• W1991499616 cites W2134329464 @default.
• W1991499616 cites W2138262820 @default.
• W1991499616 cites W2141060229 @default.
• W1991499616 cites W2143609607 @default.
• W1991499616 cites W2150132984 @default.
• W1991499616 cites W2157751549 @default.
• W1991499616 cites W2157893447 @default.
• W1991499616 cites W2158691065 @default.
• W1991499616 cites W2159953069 @default.
• W1991499616 cites W2168161193 @default.
• W1991499616 cites W2169378022 @default.
• W1991499616 cites W2170384440 @default.
• W1991499616 cites W2178730998 @default.
• W1991499616 cites W2198406525 @default.
• W1991499616 cites W2262886668 @default.
• W1991499616 cites W2318811682 @default.
• W1991499616 cites W4248835773 @default.
• W1991499616 cites W960841617 @default.

• next