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• W1991500021 abstract "Focusing on drug metabolism in liver, we constructed and evaluated a drug-metabolizing bioartificial liver (BAL) support system. In a previous study, we constructed ammonia-metabolizing CHO and hepatoma-derived HepG2 cell lines by recombination of the glutamine synthetase (GS) gene. For further mimicking of liver metabolism, the human hepatoma-derived cell line HepG2 was transformed by the pBudCE-GS-CYP3A4 vector, which contains GS and drug-metabolizing CYP 3A4 genes. The constructed GS-3A4-HepG2 cell line showed 3A4 activity higher than that of human primary hepatocytes. The drug-metabolizing activity of BAL (BAL clearance) was evaluated using this cell line. The estimated clearance was higher than that of the human hepatocyte system." @default.
• W1991500021 created "2016-06-24" @default.
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• W1991500021 date "2008-09-05" @default.
• W1991500021 modified "2023-10-18" @default.
• W1991500021 title "Construction and Evaluation of Drug-Metabolizing Cell Line for Bioartificial Liver Support System" @default.
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• W1991500021 doi "https://doi.org/10.1021/bp049757a" @default.
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