Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991505929> ?p ?o ?g. }
- W1991505929 endingPage "2236" @default.
- W1991505929 startingPage "2226" @default.
- W1991505929 abstract "Parkinson's disease (PD), a neurodegenerative disorder, causes severe motor impairment due to loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). MPTP, a neurotoxin that causes dopaminergic cell loss in mice, was used in an animal model to study the pathogenic mechanisms leading to neurodegeneration. We observed the activation of apoptosis signal regulating kinase (ASK1, MAPKKK) and phosphorylation of its downstream targets MKK4 and JNK, 12 h after administration of a single dose of MPTP. Further, Daxx, the death-associated protein, translocated to the cytosol selectively in SNpc neurons seemingly due to MPTP mediated down-regulation of DJ-1, the redox-sensitive protein that binds Daxx in the nucleus. Coadministration of alpha-lipoic acid (ALA), a thiol antioxidant, abolished the activation of ASK1 and phosphorylation of downstream kinases, MKK4, and JNK and prevented the down-regulation of DJ-1 and translocation of Daxx to the cytosol seen after MPTP. ALA also attenuated dopaminergic cell loss in SNpc seen after subchronic MPTP treatment. Our studies demonstrate for the first time that MPTP triggers death signaling pathway by activating ASK1 and translocating Daxx, in vivo, in dopaminergic neurons in SNpc of mice and thiol antioxidants, such as ALA terminate this cascade and afford neuroprotection." @default.
- W1991505929 created "2016-06-24" @default.
- W1991505929 creator A5005126539 @default.
- W1991505929 creator A5029188704 @default.
- W1991505929 creator A5046587428 @default.
- W1991505929 creator A5049822309 @default.
- W1991505929 creator A5051234390 @default.
- W1991505929 creator A5076806895 @default.
- W1991505929 creator A5090047077 @default.
- W1991505929 date "2007-03-16" @default.
- W1991505929 modified "2023-10-12" @default.
- W1991505929 title "Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death‐associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by α‐lipoic acid" @default.
- W1991505929 cites W1955897922 @default.
- W1991505929 cites W1965174801 @default.
- W1991505929 cites W1969268163 @default.
- W1991505929 cites W1972163091 @default.
- W1991505929 cites W1976976084 @default.
- W1991505929 cites W1980585130 @default.
- W1991505929 cites W1990056937 @default.
- W1991505929 cites W1990847293 @default.
- W1991505929 cites W1992749833 @default.
- W1991505929 cites W1993781471 @default.
- W1991505929 cites W2009831075 @default.
- W1991505929 cites W2010050464 @default.
- W1991505929 cites W2012357103 @default.
- W1991505929 cites W2016832784 @default.
- W1991505929 cites W2021889908 @default.
- W1991505929 cites W2026128387 @default.
- W1991505929 cites W2030558096 @default.
- W1991505929 cites W2032884792 @default.
- W1991505929 cites W2045416175 @default.
- W1991505929 cites W2054255596 @default.
- W1991505929 cites W2062833196 @default.
- W1991505929 cites W2079762064 @default.
- W1991505929 cites W2080049988 @default.
- W1991505929 cites W2101108802 @default.
- W1991505929 cites W2104382960 @default.
- W1991505929 cites W2114549483 @default.
- W1991505929 cites W2129315068 @default.
- W1991505929 cites W2133966054 @default.
- W1991505929 cites W2133995335 @default.
- W1991505929 cites W2137122673 @default.
- W1991505929 cites W2144367399 @default.
- W1991505929 cites W2146434163 @default.
- W1991505929 cites W2147309521 @default.
- W1991505929 cites W2153794304 @default.
- W1991505929 cites W2337537622 @default.
- W1991505929 cites W2460336550 @default.
- W1991505929 cites W4293247451 @default.
- W1991505929 cites W49713821 @default.
- W1991505929 doi "https://doi.org/10.1096/fj.06-7580com" @default.
- W1991505929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17369508" @default.
- W1991505929 hasPublicationYear "2007" @default.
- W1991505929 type Work @default.
- W1991505929 sameAs 1991505929 @default.
- W1991505929 citedByCount "124" @default.
- W1991505929 countsByYear W19915059292012 @default.
- W1991505929 countsByYear W19915059292013 @default.
- W1991505929 countsByYear W19915059292014 @default.
- W1991505929 countsByYear W19915059292015 @default.
- W1991505929 countsByYear W19915059292016 @default.
- W1991505929 countsByYear W19915059292017 @default.
- W1991505929 countsByYear W19915059292018 @default.
- W1991505929 countsByYear W19915059292019 @default.
- W1991505929 countsByYear W19915059292020 @default.
- W1991505929 countsByYear W19915059292021 @default.
- W1991505929 countsByYear W19915059292022 @default.
- W1991505929 countsByYear W19915059292023 @default.
- W1991505929 crossrefType "journal-article" @default.
- W1991505929 hasAuthorship W1991505929A5005126539 @default.
- W1991505929 hasAuthorship W1991505929A5029188704 @default.
- W1991505929 hasAuthorship W1991505929A5046587428 @default.
- W1991505929 hasAuthorship W1991505929A5049822309 @default.
- W1991505929 hasAuthorship W1991505929A5051234390 @default.
- W1991505929 hasAuthorship W1991505929A5076806895 @default.
- W1991505929 hasAuthorship W1991505929A5090047077 @default.
- W1991505929 hasConcept C104317684 @default.
- W1991505929 hasConcept C124160383 @default.
- W1991505929 hasConcept C126322002 @default.
- W1991505929 hasConcept C137183658 @default.
- W1991505929 hasConcept C169760540 @default.
- W1991505929 hasConcept C184235292 @default.
- W1991505929 hasConcept C185592680 @default.
- W1991505929 hasConcept C25498285 @default.
- W1991505929 hasConcept C2776773494 @default.
- W1991505929 hasConcept C2776925932 @default.
- W1991505929 hasConcept C2778674702 @default.
- W1991505929 hasConcept C2779134260 @default.
- W1991505929 hasConcept C2780938664 @default.
- W1991505929 hasConcept C29512474 @default.
- W1991505929 hasConcept C513476851 @default.
- W1991505929 hasConcept C55493867 @default.
- W1991505929 hasConcept C71924100 @default.
- W1991505929 hasConcept C82495950 @default.
- W1991505929 hasConcept C86339819 @default.
- W1991505929 hasConcept C86803240 @default.
- W1991505929 hasConcept C89380225 @default.
- W1991505929 hasConcept C95444343 @default.