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- W1991506365 abstract "Human leukemic T lymphocytes (Jurkat cells) were induced to undergo apoptosis by brief irradiation with ultraviolet C light (254 nm). This was accompanied by accumulation of lipid peroxidation products in the form of conjugated dienes, a decrease of total glutathione content, and a shift of its redox state towards the oxidized form. Preincubation of the cells with 1 mM pantothenate resulted in a significant elevation of total glutathione content of the cells, reaching its maximum level, 160% of the control, after 3 h. Similar increase was observed after preincubation with 5 mM N-acetylcysteine, a known precursor of glutathione. Both pantothenic acid and N-acetylcysteine alleviated the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protected the cells against apoptosis produced by ultraviolet irradiation." @default.
- W1991506365 created "2016-06-24" @default.
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- W1991506365 date "2001-06-01" @default.
- W1991506365 modified "2023-09-27" @default.
- W1991506365 title "Pantothenic acid protects jurkat cells against ultraviolet light-induced apoptosis" @default.
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- W1991506365 doi "https://doi.org/10.1016/s0891-5849(01)00531-7" @default.
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