FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991506593> ?p ?o ?g. }

• W1991506593 endingPage "378" @default.
• W1991506593 startingPage "372" @default.
• W1991506593 abstract "The proton-coupled electron-transfer reactions of guanine and other modified purine nucleobases have been investigated by electrochemistry and stopped-flow spectrophotometry. The rate of oxidation of guanine by Ru(bpy)33+ varied linearly with the fraction of D2O in H2O/D2O mixtures (bpy = 2,2‘-bipyridine), suggesting the involvement of a single proton, consistent with earlier studies (Weatherly, S. C.; Yang, I. V.; Thorp, H. H. J. Am. Chem. Soc. 2001, 123, 1236−1237). The oxidation of the tetrabutylammonium salt of 2‘-deoxyguanosine-5‘-monophosphate was investigated in acetonitrile. The oxidants were polypyridyl complexes of Ru(III) and Fe(III) that ranged in oxidation potential from 0.83 to 1.6 V versus SCE. The values of (RT ln k) obtained for these reactions increased with driving force with a slope of 0.5 ± 0.1, consistent with a simple electron-transfer reaction. A conventional slope of 0.5 was not observed in aqueous solution where deprotonation of the guanine nucleobase was feasible. In addition to the driving force dependence, there was a dramatic suppression in the overall rate of guanine oxidation in acetonitrile compared to water both for dilute solution and for modified electrodes. The driving force dependence for the rate of oxidation of 7-deazaguanine and 7-deazaadenine was also investigated; plots of (RT ln k) versus E1/2 showed slopes of 1.1 in aqueous solution, and these reactions gave large isotope effects ranging from 2.2 to 10, depending on the nucleobase and the oxidant. In contrast, the base 7,8-dihydro-8-oxoguanine did not exhibit an isotope effect, because the pKa of this nucleobase is known to be near 7. Taken together, these results suggest a picture where oxidation of guanine in aqueous solution by these oxidants proceeds via concerted proton-coupled electron transfer." @default.
• W1991506593 created "2016-06-24" @default.
• W1991506593 creator A5024622895 @default.
• W1991506593 creator A5026851814 @default.
• W1991506593 creator A5042472677 @default.
• W1991506593 creator A5048220671 @default.
• W1991506593 date "2002-12-06" @default.
• W1991506593 modified "2023-10-03" @default.
• W1991506593 title "Proton-Coupled Electron Transfer in Guanine Oxidation: Effects of Isotope, Solvent, and Chemical Modification" @default.
• W1991506593 cites W1592459701 @default.
• W1991506593 cites W1969408680 @default.
• W1991506593 cites W1975584921 @default.
• W1991506593 cites W1976007381 @default.
• W1991506593 cites W197782333 @default.
• W1991506593 cites W1978728011 @default.
• W1991506593 cites W1982984943 @default.
• W1991506593 cites W1986883495 @default.
• W1991506593 cites W1991210066 @default.
• W1991506593 cites W1994748126 @default.
• W1991506593 cites W2005860252 @default.
• W1991506593 cites W2012880930 @default.
• W1991506593 cites W2013718203 @default.
• W1991506593 cites W2026838497 @default.
• W1991506593 cites W2027598856 @default.
• W1991506593 cites W2034767518 @default.
• W1991506593 cites W2035258209 @default.
• W1991506593 cites W2036036836 @default.
• W1991506593 cites W2037211079 @default.
• W1991506593 cites W2040843368 @default.
• W1991506593 cites W2043879709 @default.
• W1991506593 cites W2056768042 @default.
• W1991506593 cites W2058539635 @default.
• W1991506593 cites W2059305877 @default.
• W1991506593 cites W2064040987 @default.
• W1991506593 cites W2068602969 @default.
• W1991506593 cites W2074399070 @default.
• W1991506593 cites W2075570601 @default.
• W1991506593 cites W2076443604 @default.
• W1991506593 cites W2082280452 @default.
• W1991506593 cites W2105302993 @default.
• W1991506593 cites W2131577044 @default.
• W1991506593 cites W2614884730 @default.
• W1991506593 cites W2949876576 @default.
• W1991506593 cites W4245399940 @default.
• W1991506593 doi "https://doi.org/10.1021/jp022085r" @default.
• W1991506593 hasPublicationYear "2002" @default.
• W1991506593 type Work @default.
• W1991506593 sameAs 1991506593 @default.
• W1991506593 citedByCount "54" @default.
• W1991506593 countsByYear W19915065932012 @default.
• W1991506593 countsByYear W19915065932013 @default.
• W1991506593 countsByYear W19915065932014 @default.
• W1991506593 countsByYear W19915065932018 @default.
• W1991506593 countsByYear W19915065932019 @default.
• W1991506593 countsByYear W19915065932021 @default.
• W1991506593 crossrefType "journal-article" @default.
• W1991506593 hasAuthorship W1991506593A5024622895 @default.
• W1991506593 hasAuthorship W1991506593A5026851814 @default.
• W1991506593 hasAuthorship W1991506593A5042472677 @default.
• W1991506593 hasAuthorship W1991506593A5048220671 @default.
• W1991506593 hasConcept C104317684 @default.
• W1991506593 hasConcept C118629725 @default.
• W1991506593 hasConcept C121332964 @default.
• W1991506593 hasConcept C123669783 @default.
• W1991506593 hasConcept C134306372 @default.
• W1991506593 hasConcept C145148216 @default.
• W1991506593 hasConcept C147789679 @default.
• W1991506593 hasConcept C17525397 @default.
• W1991506593 hasConcept C178790620 @default.
• W1991506593 hasConcept C179104552 @default.
• W1991506593 hasConcept C184651966 @default.
• W1991506593 hasConcept C185592680 @default.
• W1991506593 hasConcept C2777463227 @default.
• W1991506593 hasConcept C2778301229 @default.
• W1991506593 hasConcept C30095370 @default.
• W1991506593 hasConcept C33923547 @default.
• W1991506593 hasConcept C42058472 @default.
• W1991506593 hasConcept C512185932 @default.
• W1991506593 hasConcept C52859227 @default.
• W1991506593 hasConcept C552990157 @default.
• W1991506593 hasConcept C55493867 @default.
• W1991506593 hasConcept C55904794 @default.
• W1991506593 hasConcept C58364064 @default.
• W1991506593 hasConcept C61234307 @default.
• W1991506593 hasConcept C62520636 @default.
• W1991506593 hasConcept C69928629 @default.
• W1991506593 hasConcept C75473681 @default.
• W1991506593 hasConceptScore W1991506593C104317684 @default.
• W1991506593 hasConceptScore W1991506593C118629725 @default.
• W1991506593 hasConceptScore W1991506593C121332964 @default.
• W1991506593 hasConceptScore W1991506593C123669783 @default.
• W1991506593 hasConceptScore W1991506593C134306372 @default.
• W1991506593 hasConceptScore W1991506593C145148216 @default.
• W1991506593 hasConceptScore W1991506593C147789679 @default.
• W1991506593 hasConceptScore W1991506593C17525397 @default.
• W1991506593 hasConceptScore W1991506593C178790620 @default.
• W1991506593 hasConceptScore W1991506593C179104552 @default.
• W1991506593 hasConceptScore W1991506593C184651966 @default.

• next