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• W1991517861 startingPage "e54924" @default.
• W1991517861 abstract "Prenatal exposure to high levels of alcohol is strongly associated with poor cognitive outcomes particularly in relation to learning and memory. It is also becoming more evident that anxiety disorders and anxiety-like behaviour can be associated with prenatal alcohol exposure. This study used a rat model to determine if prenatal exposure to a relatively small amount of alcohol would result in anxiety-like behaviour and to determine if this was associated with morphological changes in the basolateral amygdala. Pregnant Sprague Dawley rats were fed a liquid diet containing either no alcohol (Control) or 6% (vol/vol) ethanol (EtOH) throughout gestation. Male and Female offspring underwent behavioural testing at 8 months (Adult) or 15 months (Aged) of age. Rats were perfusion fixed and brains were collected at the end of behavioural testing for morphological analysis of pyramidal neuron number and dendritic morphology within the basolateral amygdala. EtOH exposed offspring displayed anxiety-like behaviour in the elevated plus maze, holeboard and emergence tests. Although sexually dimorphic behaviour was apparent, sex did not impact anxiety-like behaviour induced by prenatal alcohol exposure. This increase in anxiety - like behaviour could not be attributed to a change in pyramidal cell number within the BLA but rather was associated with an increase in dendritic spines along the apical dendrite which is indicative of an increase in synaptic connectivity and activity within these neurons. This study is the first to link increases in anxiety like behaviour to structural changes within the basolateral amygdala in a model of prenatal ethanol exposure. In addition, this study has shown that exposure to even a relatively small amount of alcohol during development leads to long term alterations in anxiety-like behaviour." @default.
• W1991517861 created "2016-06-24" @default.
• W1991517861 creator A5013597364 @default.
• W1991517861 creator A5013676374 @default.
• W1991517861 creator A5055500460 @default.
• W1991517861 creator A5073153817 @default.
• W1991517861 date "2013-01-30" @default.
• W1991517861 modified "2023-10-14" @default.
• W1991517861 title "Low Dose Prenatal Ethanol Exposure Induces Anxiety-Like Behaviour and Alters Dendritic Morphology in the Basolateral Amygdala of Rat Offspring" @default.
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• W1991517861 doi "https://doi.org/10.1371/journal.pone.0054924" @default.
• W1991517861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3559882" @default.
• W1991517861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23383000" @default.
• W1991517861 hasPublicationYear "2013" @default.
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