FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991520469> ?p ?o ?g. }

• W1991520469 endingPage "112" @default.
• W1991520469 startingPage "106" @default.
• W1991520469 abstract "Background— Current paradigm attributes the low incidence of cardiovascular disorders in Mediterranean countries despite a high saturated fat intake, the “French paradox,” to the antioxidant capacity of red wine polyphenols. Conceivably, other antiinflammatory pathways may contribute to at least a similar extent to the atheroprotective activity of these polyphenols. We have investigated whether gallic acid (GA), an abundant red wine polyphenol, modulates the activity of P-selectin, an adhesion molecule that is critically involved in the recruitment of inflammatory cells to the vessel wall and thus in atherosclerosis. Methods and Results— GA potently inhibited the binding of a peptide antagonist (IC 50 , 7.2 μmol/L) and biotin-PAA-Le a -SO 3 H, an established high-affinity ligand, to P-selectin (IC 50 , 85 μmol/L). Under dynamic flow conditions, GA markedly and dose dependently attenuated the rolling of monocytic HL60 cells over P-selectin-transfected Chinese hamster ovary cells (EC 50 , 14.5 μmol/L) while increasing the velocity of P-selectin-dependent rolling of human blood leukocytes over a platelet monolayer. In vivo tests established that GA administration to normolipidemic C57/Bl6 and aged atherosclerotic apolipoprotein E–deficient mice impaired the baseline rolling of conjugates between activated platelets and circulating monocytes over femoral vein endothelium, as judged by online video microscopy (ED 50 , 1.7±0.3 and 1.5±0.4 mg · kg −1 · h −1 , respectively). Conclusions— Our findings provide a solid mechanistic foundation through which GA intervenes in major inflammatory pathobiologies by binding and antagonizing P-selectin." @default.
• W1991520469 created "2016-06-24" @default.
• W1991520469 creator A5006329944 @default.
• W1991520469 creator A5009566495 @default.
• W1991520469 creator A5015759472 @default.
• W1991520469 creator A5019598572 @default.
• W1991520469 creator A5024733637 @default.
• W1991520469 creator A5025874738 @default.
• W1991520469 creator A5080571568 @default.
• W1991520469 date "2005-01-04" @default.
• W1991520469 modified "2023-10-07" @default.
• W1991520469 title "Gallic Acid Antagonizes P-Selectin–Mediated Platelet–Leukocyte Interactions" @default.
• W1991520469 cites W126725029 @default.
• W1991520469 cites W1528569576 @default.
• W1991520469 cites W1569215079 @default.
• W1991520469 cites W1837360856 @default.
• W1991520469 cites W1954376585 @default.
• W1991520469 cites W1964860341 @default.
• W1991520469 cites W1980618862 @default.
• W1991520469 cites W1983177609 @default.
• W1991520469 cites W1991066258 @default.
• W1991520469 cites W1996363417 @default.
• W1991520469 cites W2011978654 @default.
• W1991520469 cites W2012264200 @default.
• W1991520469 cites W2025220259 @default.
• W1991520469 cites W2025751355 @default.
• W1991520469 cites W2029515542 @default.
• W1991520469 cites W2032971951 @default.
• W1991520469 cites W2040692157 @default.
• W1991520469 cites W2047916715 @default.
• W1991520469 cites W2049806614 @default.
• W1991520469 cites W2054065847 @default.
• W1991520469 cites W2058557786 @default.
• W1991520469 cites W2079844004 @default.
• W1991520469 cites W2088355928 @default.
• W1991520469 cites W2089750544 @default.
• W1991520469 cites W2098739396 @default.
• W1991520469 cites W2102667962 @default.
• W1991520469 cites W2118095126 @default.
• W1991520469 cites W2140336796 @default.
• W1991520469 cites W2143333940 @default.
• W1991520469 cites W2148078723 @default.
• W1991520469 cites W2154745788 @default.
• W1991520469 cites W2155793158 @default.
• W1991520469 cites W3111440177 @default.
• W1991520469 cites W4323282404 @default.
• W1991520469 doi "https://doi.org/10.1161/01.cir.0000151307.10576.02" @default.
• W1991520469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15630039" @default.
• W1991520469 hasPublicationYear "2005" @default.
• W1991520469 type Work @default.
• W1991520469 sameAs 1991520469 @default.
• W1991520469 citedByCount "60" @default.
• W1991520469 countsByYear W19915204692012 @default.
• W1991520469 countsByYear W19915204692013 @default.
• W1991520469 countsByYear W19915204692014 @default.
• W1991520469 countsByYear W19915204692015 @default.
• W1991520469 countsByYear W19915204692016 @default.
• W1991520469 countsByYear W19915204692017 @default.
• W1991520469 countsByYear W19915204692018 @default.
• W1991520469 countsByYear W19915204692020 @default.
• W1991520469 countsByYear W19915204692021 @default.
• W1991520469 countsByYear W19915204692022 @default.
• W1991520469 countsByYear W19915204692023 @default.
• W1991520469 crossrefType "journal-article" @default.
• W1991520469 hasAuthorship W1991520469A5006329944 @default.
• W1991520469 hasAuthorship W1991520469A5009566495 @default.
• W1991520469 hasAuthorship W1991520469A5015759472 @default.
• W1991520469 hasAuthorship W1991520469A5019598572 @default.
• W1991520469 hasAuthorship W1991520469A5024733637 @default.
• W1991520469 hasAuthorship W1991520469A5025874738 @default.
• W1991520469 hasAuthorship W1991520469A5080571568 @default.
• W1991520469 hasBestOaLocation W19915204691 @default.
• W1991520469 hasConcept C126322002 @default.
• W1991520469 hasConcept C134018914 @default.
• W1991520469 hasConcept C170493617 @default.
• W1991520469 hasConcept C175656101 @default.
• W1991520469 hasConcept C185592680 @default.
• W1991520469 hasConcept C203014093 @default.
• W1991520469 hasConcept C2778004101 @default.
• W1991520469 hasConcept C2778362808 @default.
• W1991520469 hasConcept C2779828298 @default.
• W1991520469 hasConcept C3018697912 @default.
• W1991520469 hasConcept C55493867 @default.
• W1991520469 hasConcept C56701166 @default.
• W1991520469 hasConcept C71924100 @default.
• W1991520469 hasConcept C89560881 @default.
• W1991520469 hasConcept C98274493 @default.
• W1991520469 hasConceptScore W1991520469C126322002 @default.
• W1991520469 hasConceptScore W1991520469C134018914 @default.
• W1991520469 hasConceptScore W1991520469C170493617 @default.
• W1991520469 hasConceptScore W1991520469C175656101 @default.
• W1991520469 hasConceptScore W1991520469C185592680 @default.
• W1991520469 hasConceptScore W1991520469C203014093 @default.
• W1991520469 hasConceptScore W1991520469C2778004101 @default.
• W1991520469 hasConceptScore W1991520469C2778362808 @default.
• W1991520469 hasConceptScore W1991520469C2779828298 @default.
• W1991520469 hasConceptScore W1991520469C3018697912 @default.
• W1991520469 hasConceptScore W1991520469C55493867 @default.

• next