FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991520502> ?p ?o ?g. }

• W1991520502 endingPage "456" @default.
• W1991520502 startingPage "453" @default.
• W1991520502 abstract "The effects of three non-steroidal anti-inflammatory drugs (NSAIDs) on the pharmacokinetics of methotrexate were studied in 10 patients with rheumatoid arthritis. Ketoprofen (3 mg kg-1 day-1), flurbiprofen (3 mg kg-1 day-1), piroxicam (20 mg day-1), or a non-NSAID control (paracetamol/acetaminophen) were administered to patients for at least 6 days (13 days in the case of piroxicam to establish steady state) in a randomized crossover design prior to receiving a weekly oral dose of methotrexate. In the non-NSAID control portion of the study, MTX oral clearance (CLo) was 11.0 +/- 3.9 l h-1, renal clearance (CLR) was 7.9 +/- 2.8 l h-1, percent excreted unchanged was 72 +2- 19% and fraction unbound (fu) was 0.54 +/- 0.11. Values of oral clearance, renal clearance, fraction unbound and percentage excreted unchanged of methotrexate varied no more than 12.2% from non-NSAID control during concomitant administration of ketoprofen, flurbiprofen or piroxicam and were not statistically different from non-NSAID control. In contrast to other NSAIDs such as ibuprofen and salicylates, ketoprofen, flurbiprofen or piroxicam in clinically relevant doses do not appear to affect methotrexate disposition and may be used safely in combination with methotrexate." @default.
• W1991520502 created "2016-06-24" @default.
• W1991520502 creator A5007369644 @default.
• W1991520502 creator A5014633844 @default.
• W1991520502 creator A5027305662 @default.
• W1991520502 creator A5028295553 @default.
• W1991520502 creator A5057501354 @default.
• W1991520502 date "1994-05-01" @default.
• W1991520502 modified "2023-09-27" @default.
• W1991520502 title "Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis." @default.
• W1991520502 cites W1890321163 @default.
• W1991520502 cites W1966641649 @default.
• W1991520502 cites W1968910365 @default.
• W1991520502 cites W2011788730 @default.
• W1991520502 cites W2014505705 @default.
• W1991520502 cites W2016284731 @default.
• W1991520502 cites W2066806870 @default.
• W1991520502 cites W2066873579 @default.
• W1991520502 cites W2079100622 @default.
• W1991520502 cites W2080761160 @default.
• W1991520502 cites W2112187168 @default.
• W1991520502 cites W2115500323 @default.
• W1991520502 cites W2138814539 @default.
• W1991520502 cites W2152348310 @default.
• W1991520502 cites W2236994532 @default.
• W1991520502 cites W2403776894 @default.
• W1991520502 cites W2406692965 @default.
• W1991520502 cites W2430921741 @default.
• W1991520502 doi "https://doi.org/10.1111/j.1365-2125.1994.tb05713.x" @default.
• W1991520502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1364901" @default.
• W1991520502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8054251" @default.
• W1991520502 hasPublicationYear "1994" @default.
• W1991520502 type Work @default.
• W1991520502 sameAs 1991520502 @default.
• W1991520502 citedByCount "58" @default.
• W1991520502 countsByYear W19915205022012 @default.
• W1991520502 countsByYear W19915205022014 @default.
• W1991520502 countsByYear W19915205022016 @default.
• W1991520502 countsByYear W19915205022019 @default.
• W1991520502 countsByYear W19915205022020 @default.
• W1991520502 countsByYear W19915205022021 @default.
• W1991520502 countsByYear W19915205022022 @default.
• W1991520502 countsByYear W19915205022023 @default.
• W1991520502 crossrefType "journal-article" @default.
• W1991520502 hasAuthorship W1991520502A5007369644 @default.
• W1991520502 hasAuthorship W1991520502A5014633844 @default.
• W1991520502 hasAuthorship W1991520502A5027305662 @default.
• W1991520502 hasAuthorship W1991520502A5028295553 @default.
• W1991520502 hasAuthorship W1991520502A5057501354 @default.
• W1991520502 hasBestOaLocation W19915205021 @default.
• W1991520502 hasConcept C112705442 @default.
• W1991520502 hasConcept C126322002 @default.
• W1991520502 hasConcept C142724271 @default.
• W1991520502 hasConcept C204787440 @default.
• W1991520502 hasConcept C27081682 @default.
• W1991520502 hasConcept C2777056448 @default.
• W1991520502 hasConcept C2777575956 @default.
• W1991520502 hasConcept C2778139025 @default.
• W1991520502 hasConcept C2778722691 @default.
• W1991520502 hasConcept C2779384505 @default.
• W1991520502 hasConcept C2779944601 @default.
• W1991520502 hasConcept C2780744026 @default.
• W1991520502 hasConcept C2781000538 @default.
• W1991520502 hasConcept C2781059491 @default.
• W1991520502 hasConcept C71924100 @default.
• W1991520502 hasConcept C87813604 @default.
• W1991520502 hasConcept C98274493 @default.
• W1991520502 hasConceptScore W1991520502C112705442 @default.
• W1991520502 hasConceptScore W1991520502C126322002 @default.
• W1991520502 hasConceptScore W1991520502C142724271 @default.
• W1991520502 hasConceptScore W1991520502C204787440 @default.
• W1991520502 hasConceptScore W1991520502C27081682 @default.
• W1991520502 hasConceptScore W1991520502C2777056448 @default.
• W1991520502 hasConceptScore W1991520502C2777575956 @default.
• W1991520502 hasConceptScore W1991520502C2778139025 @default.
• W1991520502 hasConceptScore W1991520502C2778722691 @default.
• W1991520502 hasConceptScore W1991520502C2779384505 @default.
• W1991520502 hasConceptScore W1991520502C2779944601 @default.
• W1991520502 hasConceptScore W1991520502C2780744026 @default.
• W1991520502 hasConceptScore W1991520502C2781000538 @default.
• W1991520502 hasConceptScore W1991520502C2781059491 @default.
• W1991520502 hasConceptScore W1991520502C71924100 @default.
• W1991520502 hasConceptScore W1991520502C87813604 @default.
• W1991520502 hasConceptScore W1991520502C98274493 @default.
• W1991520502 hasIssue "5" @default.
• W1991520502 hasLocation W19915205021 @default.
• W1991520502 hasLocation W19915205022 @default.
• W1991520502 hasLocation W19915205023 @default.
• W1991520502 hasLocation W19915205024 @default.
• W1991520502 hasOpenAccess W1991520502 @default.
• W1991520502 hasPrimaryLocation W19915205021 @default.
• W1991520502 hasRelatedWork W1969876219 @default.
• W1991520502 hasRelatedWork W1984317973 @default.
• W1991520502 hasRelatedWork W1991520502 @default.
• W1991520502 hasRelatedWork W2049223264 @default.
• W1991520502 hasRelatedWork W2090551155 @default.
• W1991520502 hasRelatedWork W2101502799 @default.
• W1991520502 hasRelatedWork W2106194210 @default.

• next