Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991530152> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1991530152 endingPage "242" @default.
- W1991530152 startingPage "240" @default.
- W1991530152 abstract "Mitochondrial function is fundamental to metabolic homeostasis. In addition to converting the nutrient flux into the energy molecule ATP, the mitochondria generate intermediates for biosynthesis and reactive oxygen species (ROS) that serve as a secondary messenger to mediate signal transduction and metabolism. Alterations of mitochondrial function, dynamics, and biogenesis have been observed in various metabolic disorders, including aging, cancer, diabetes, and obesity. However, the mechanisms responsible for mitochondrial changes and the pathways leading to metabolic disorders remain to be defined. In the last few years, tremendous efforts have been devoted to addressing these complex questions and led to a significant progress. In a timely manner, the Forum on Mitochondria and Metabolic Homeostasis intends to document the latest findings in both the original research article and review articles, with the focus on addressing three major complex issues: (1) mitochondria and mitochondrial oxidants in aging—the oxidant theory (including mitochondrial ROS) being revisited by a hyperfunction hypothesis and a novel role of SMRT in mitochondrion-mediated aging process being discussed; (2) impaired mitochondrial capacity (e.g., fatty acid oxidation and oxidative phosphorylation [OXPHOS] for ATP synthesis) and plasticity (e.g., the response to endocrine and metabolic challenges, and to calorie restriction) in diabetes and obesity; (3) mitochondrial energy adaption in cancer progression—a new view being provided for H+-ATP synthase in regulating cell cycle and proliferation by mediating mitochondrial OXPHOS, oxidant production, and cell death signaling. It is anticipated that this timely Forum will advance our understanding of mitochondrial dysfunction in metabolic disorders. Antioxid. Redox Signal. 19, 240–242." @default.
- W1991530152 created "2016-06-24" @default.
- W1991530152 creator A5037495777 @default.
- W1991530152 creator A5047183170 @default.
- W1991530152 date "2013-07-20" @default.
- W1991530152 modified "2023-10-16" @default.
- W1991530152 title "Mitochondria and Metabolic Homeostasis" @default.
- W1991530152 cites W1975625687 @default.
- W1991530152 cites W1978320854 @default.
- W1991530152 cites W2034508560 @default.
- W1991530152 cites W2034773856 @default.
- W1991530152 cites W2056420027 @default.
- W1991530152 cites W2063574189 @default.
- W1991530152 cites W2091944089 @default.
- W1991530152 cites W2119314929 @default.
- W1991530152 cites W2134183006 @default.
- W1991530152 doi "https://doi.org/10.1089/ars.2013.5255" @default.
- W1991530152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23432475" @default.
- W1991530152 hasPublicationYear "2013" @default.
- W1991530152 type Work @default.
- W1991530152 sameAs 1991530152 @default.
- W1991530152 citedByCount "136" @default.
- W1991530152 countsByYear W19915301522013 @default.
- W1991530152 countsByYear W19915301522014 @default.
- W1991530152 countsByYear W19915301522015 @default.
- W1991530152 countsByYear W19915301522016 @default.
- W1991530152 countsByYear W19915301522017 @default.
- W1991530152 countsByYear W19915301522018 @default.
- W1991530152 countsByYear W19915301522019 @default.
- W1991530152 countsByYear W19915301522020 @default.
- W1991530152 countsByYear W19915301522021 @default.
- W1991530152 countsByYear W19915301522022 @default.
- W1991530152 countsByYear W19915301522023 @default.
- W1991530152 crossrefType "journal-article" @default.
- W1991530152 hasAuthorship W1991530152A5037495777 @default.
- W1991530152 hasAuthorship W1991530152A5047183170 @default.
- W1991530152 hasConcept C170493617 @default.
- W1991530152 hasConcept C194082555 @default.
- W1991530152 hasConcept C2491326 @default.
- W1991530152 hasConcept C2776030549 @default.
- W1991530152 hasConcept C2777229759 @default.
- W1991530152 hasConcept C28859421 @default.
- W1991530152 hasConcept C55493867 @default.
- W1991530152 hasConcept C57600042 @default.
- W1991530152 hasConcept C62478195 @default.
- W1991530152 hasConcept C86803240 @default.
- W1991530152 hasConcept C95444343 @default.
- W1991530152 hasConceptScore W1991530152C170493617 @default.
- W1991530152 hasConceptScore W1991530152C194082555 @default.
- W1991530152 hasConceptScore W1991530152C2491326 @default.
- W1991530152 hasConceptScore W1991530152C2776030549 @default.
- W1991530152 hasConceptScore W1991530152C2777229759 @default.
- W1991530152 hasConceptScore W1991530152C28859421 @default.
- W1991530152 hasConceptScore W1991530152C55493867 @default.
- W1991530152 hasConceptScore W1991530152C57600042 @default.
- W1991530152 hasConceptScore W1991530152C62478195 @default.
- W1991530152 hasConceptScore W1991530152C86803240 @default.
- W1991530152 hasConceptScore W1991530152C95444343 @default.
- W1991530152 hasIssue "3" @default.
- W1991530152 hasLocation W19915301521 @default.
- W1991530152 hasLocation W19915301522 @default.
- W1991530152 hasOpenAccess W1991530152 @default.
- W1991530152 hasPrimaryLocation W19915301521 @default.
- W1991530152 hasRelatedWork W2025172936 @default.
- W1991530152 hasRelatedWork W2040314403 @default.
- W1991530152 hasRelatedWork W2048396457 @default.
- W1991530152 hasRelatedWork W2053347391 @default.
- W1991530152 hasRelatedWork W2057182111 @default.
- W1991530152 hasRelatedWork W2074128054 @default.
- W1991530152 hasRelatedWork W2101645650 @default.
- W1991530152 hasRelatedWork W2136838575 @default.
- W1991530152 hasRelatedWork W2336611004 @default.
- W1991530152 hasRelatedWork W2509379777 @default.
- W1991530152 hasVolume "19" @default.
- W1991530152 isParatext "false" @default.
- W1991530152 isRetracted "false" @default.
- W1991530152 magId "1991530152" @default.
- W1991530152 workType "article" @default.