FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991535467> ?p ?o ?g. }

• W1991535467 endingPage "1399" @default.
• W1991535467 startingPage "1393" @default.
• W1991535467 abstract "BackgroundIn chronic obstructive pulmonary disease (COPD) the clinical efficacy of bronchodilator therapy delivered via a nebulizer versus an aerochamber on FEV1 is controversial. No studies comparing changes in inspiratory pulmonary function parameters (ILPs) using these inhaler devices are currently available. This information might be of interest because due to dynamic bronchial compression, the relationship between the ILPs and dyspnea is more reliable than that between FEV1 and dyspnea. Therefore, our study aimed to investigate whether changes in ILPs after use of these inhaler devices were similar to the changes in FEV1 and correlate with VAS (Visual Analogue Scale).MethodsForty-one stable COPD patients participated in a crossover trial. Spirometry was performed before and after two puffs Combivent (200 mcg salbutamol and 20 mcg ipratropium per puff) using an aerochamber or 2 mL of Combivent (2.5 mg salbutamol and 250 mcg ipratropium per mL) using a nebulizer. Differences in lung function parameters and changes in VAS were measured.ResultsILP values improved significantly from baseline after Combivent administration using both devices (p ≤ 0.004). With both devices, the mean percent changes were significantly greater for FEV1 than the ILPs (p ≤ 0.003), except for IC (p = 0.19). The mean VAS score did not differ significantly between the devices (p = 0.33), but significant correlations were found between the VAS and forced inspiratory flow at 50% of the vital capacity (FIF50) and peak inspiratory flow (PIF) when a nebulizer was used. With an aerochamber, no significant correlations between lung function parameters and VAS were found.ConclusionsThe present study demonstrates that ILPs improved significantly after using either device. Although significant correlations were found between the VAS and FIF50 and PIF for the nebulizer, in stable COPD patients, the pMDI plus spacer is a better route of administration than a nebulizer. In chronic obstructive pulmonary disease (COPD) the clinical efficacy of bronchodilator therapy delivered via a nebulizer versus an aerochamber on FEV1 is controversial. No studies comparing changes in inspiratory pulmonary function parameters (ILPs) using these inhaler devices are currently available. This information might be of interest because due to dynamic bronchial compression, the relationship between the ILPs and dyspnea is more reliable than that between FEV1 and dyspnea. Therefore, our study aimed to investigate whether changes in ILPs after use of these inhaler devices were similar to the changes in FEV1 and correlate with VAS (Visual Analogue Scale). Forty-one stable COPD patients participated in a crossover trial. Spirometry was performed before and after two puffs Combivent (200 mcg salbutamol and 20 mcg ipratropium per puff) using an aerochamber or 2 mL of Combivent (2.5 mg salbutamol and 250 mcg ipratropium per mL) using a nebulizer. Differences in lung function parameters and changes in VAS were measured. ILP values improved significantly from baseline after Combivent administration using both devices (p ≤ 0.004). With both devices, the mean percent changes were significantly greater for FEV1 than the ILPs (p ≤ 0.003), except for IC (p = 0.19). The mean VAS score did not differ significantly between the devices (p = 0.33), but significant correlations were found between the VAS and forced inspiratory flow at 50% of the vital capacity (FIF50) and peak inspiratory flow (PIF) when a nebulizer was used. With an aerochamber, no significant correlations between lung function parameters and VAS were found. The present study demonstrates that ILPs improved significantly after using either device. Although significant correlations were found between the VAS and FIF50 and PIF for the nebulizer, in stable COPD patients, the pMDI plus spacer is a better route of administration than a nebulizer." @default.
• W1991535467 created "2016-06-24" @default.
• W1991535467 creator A5018202950 @default.
• W1991535467 creator A5028109035 @default.
• W1991535467 creator A5030608314 @default.
• W1991535467 creator A5047715110 @default.
• W1991535467 creator A5058403035 @default.
• W1991535467 date "2013-09-01" @default.
• W1991535467 modified "2023-10-17" @default.
• W1991535467 title "The effect of bronchodilators administered via aerochamber or a nebulizer on inspiratory lung function parameters" @default.
• W1991535467 cites W1759853989 @default.
• W1991535467 cites W1891804292 @default.
• W1991535467 cites W1937708066 @default.
• W1991535467 cites W1973224637 @default.
• W1991535467 cites W1976285959 @default.
• W1991535467 cites W2002082935 @default.
• W1991535467 cites W2005805181 @default.
• W1991535467 cites W2037655414 @default.
• W1991535467 cites W2045616259 @default.
• W1991535467 cites W2051400033 @default.
• W1991535467 cites W2058052338 @default.
• W1991535467 cites W2061421540 @default.
• W1991535467 cites W2069615503 @default.
• W1991535467 cites W2071230213 @default.
• W1991535467 cites W2079928252 @default.
• W1991535467 cites W2081406688 @default.
• W1991535467 cites W2083398388 @default.
• W1991535467 cites W2089907463 @default.
• W1991535467 cites W2097125229 @default.
• W1991535467 cites W2121192844 @default.
• W1991535467 cites W2121914298 @default.
• W1991535467 cites W2122498329 @default.
• W1991535467 cites W2130363761 @default.
• W1991535467 cites W2133336496 @default.
• W1991535467 cites W2134005182 @default.
• W1991535467 cites W2140730458 @default.
• W1991535467 cites W2146161694 @default.
• W1991535467 cites W2149996749 @default.
• W1991535467 cites W2155395559 @default.
• W1991535467 cites W2160693139 @default.
• W1991535467 cites W2160878528 @default.
• W1991535467 cites W2166432084 @default.
• W1991535467 cites W2167079141 @default.
• W1991535467 cites W2613729619 @default.
• W1991535467 cites W4235167053 @default.
• W1991535467 doi "https://doi.org/10.1016/j.rmed.2013.05.008" @default.
• W1991535467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23768736" @default.
• W1991535467 hasPublicationYear "2013" @default.
• W1991535467 type Work @default.
• W1991535467 sameAs 1991535467 @default.
• W1991535467 citedByCount "5" @default.
• W1991535467 countsByYear W19915354672014 @default.
• W1991535467 countsByYear W19915354672016 @default.
• W1991535467 countsByYear W19915354672017 @default.
• W1991535467 countsByYear W19915354672020 @default.
• W1991535467 crossrefType "journal-article" @default.
• W1991535467 hasAuthorship W1991535467A5018202950 @default.
• W1991535467 hasAuthorship W1991535467A5028109035 @default.
• W1991535467 hasAuthorship W1991535467A5030608314 @default.
• W1991535467 hasAuthorship W1991535467A5047715110 @default.
• W1991535467 hasAuthorship W1991535467A5058403035 @default.
• W1991535467 hasBestOaLocation W19915354671 @default.
• W1991535467 hasConcept C126322002 @default.
• W1991535467 hasConcept C14184104 @default.
• W1991535467 hasConcept C142724271 @default.
• W1991535467 hasConcept C204787440 @default.
• W1991535467 hasConcept C27081682 @default.
• W1991535467 hasConcept C27101514 @default.
• W1991535467 hasConcept C2776042228 @default.
• W1991535467 hasConcept C2776727875 @default.
• W1991535467 hasConcept C2776780178 @default.
• W1991535467 hasConcept C2776954882 @default.
• W1991535467 hasConcept C2777394947 @default.
• W1991535467 hasConcept C2777714996 @default.
• W1991535467 hasConcept C2780261241 @default.
• W1991535467 hasConcept C2780333948 @default.
• W1991535467 hasConcept C2780352487 @default.
• W1991535467 hasConcept C2780532441 @default.
• W1991535467 hasConcept C2780667556 @default.
• W1991535467 hasConcept C2781018748 @default.
• W1991535467 hasConcept C2781142857 @default.
• W1991535467 hasConcept C2908933175 @default.
• W1991535467 hasConcept C2909548125 @default.
• W1991535467 hasConcept C2909577894 @default.
• W1991535467 hasConcept C42219234 @default.
• W1991535467 hasConcept C71924100 @default.
• W1991535467 hasConcept C75603125 @default.
• W1991535467 hasConcept C87813604 @default.
• W1991535467 hasConceptScore W1991535467C126322002 @default.
• W1991535467 hasConceptScore W1991535467C14184104 @default.
• W1991535467 hasConceptScore W1991535467C142724271 @default.
• W1991535467 hasConceptScore W1991535467C204787440 @default.
• W1991535467 hasConceptScore W1991535467C27081682 @default.
• W1991535467 hasConceptScore W1991535467C27101514 @default.
• W1991535467 hasConceptScore W1991535467C2776042228 @default.
• W1991535467 hasConceptScore W1991535467C2776727875 @default.
• W1991535467 hasConceptScore W1991535467C2776780178 @default.
• W1991535467 hasConceptScore W1991535467C2776954882 @default.

• next