Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991536280> ?p ?o ?g. }
- W1991536280 endingPage "3971" @default.
- W1991536280 startingPage "3957" @default.
- W1991536280 abstract "Poly(methacrylic acid-methyl methacrylate, 1:2) (Eudragit S) is a commonly used pH-responsive polymer that can facilitate delivery to the ileo-colonic region of the gastrointestinal tract. Different plasticizers have been used to reduce the brittleness of Eudragit S films for the coating of solid dosage forms. To better correlate the dissolution rates of Eudragit S films, we have examined their dielectric response to understand the specific polymer-plasticizer interactions. Solvent cast Eudragit S films were prepared with one of four citrate plasticizers ranging from low to moderate aqueous solubility. Film dissolution was determined using a two-compartment permeation cell. Dielectric properties were measured by thermally stimulated depolarisation currents (TSDC). Secondary relaxations were deconvoluted and identified. The glass transition temperature (T(g)) was measured using TSDC, differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). Dissolution of the films was influenced by the solubility and structure of the plasticizers. While no correlation was found among the T(g)'s obtained by TSDC, DSC, and DMA with dissolution time, the low temperature TSDC spectra showed a relationship of the total secondary relaxation area and relaxation of the carboxylic acid functional group with dissolution time. Dielectric secondary relaxations may be a good probe to predict plasticizer influence on dissolution of Eudragit S polymer films." @default.
- W1991536280 created "2016-06-24" @default.
- W1991536280 creator A5006606585 @default.
- W1991536280 creator A5006674934 @default.
- W1991536280 creator A5012454280 @default.
- W1991536280 creator A5020162492 @default.
- W1991536280 creator A5020960555 @default.
- W1991536280 creator A5035169036 @default.
- W1991536280 creator A5076982441 @default.
- W1991536280 date "2008-09-01" @default.
- W1991536280 modified "2023-10-18" @default.
- W1991536280 title "The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films" @default.
- W1991536280 cites W123316195 @default.
- W1991536280 cites W1571605083 @default.
- W1991536280 cites W1971084041 @default.
- W1991536280 cites W1971751203 @default.
- W1991536280 cites W1974387428 @default.
- W1991536280 cites W1975447565 @default.
- W1991536280 cites W1976615671 @default.
- W1991536280 cites W1977499109 @default.
- W1991536280 cites W1978010452 @default.
- W1991536280 cites W1984056224 @default.
- W1991536280 cites W1986434619 @default.
- W1991536280 cites W1986506203 @default.
- W1991536280 cites W1987963100 @default.
- W1991536280 cites W2004571378 @default.
- W1991536280 cites W2019260026 @default.
- W1991536280 cites W2026307141 @default.
- W1991536280 cites W2027648775 @default.
- W1991536280 cites W2027771776 @default.
- W1991536280 cites W2044875469 @default.
- W1991536280 cites W2046159379 @default.
- W1991536280 cites W2057009283 @default.
- W1991536280 cites W2057269076 @default.
- W1991536280 cites W2072209168 @default.
- W1991536280 cites W2075869374 @default.
- W1991536280 cites W2076345852 @default.
- W1991536280 cites W2078224833 @default.
- W1991536280 cites W2081651429 @default.
- W1991536280 cites W2082974332 @default.
- W1991536280 cites W2088981039 @default.
- W1991536280 cites W2089407496 @default.
- W1991536280 cites W2095502385 @default.
- W1991536280 cites W2107316599 @default.
- W1991536280 cites W2143363925 @default.
- W1991536280 cites W2229458037 @default.
- W1991536280 cites W24460488 @default.
- W1991536280 cites W310496310 @default.
- W1991536280 cites W4253218998 @default.
- W1991536280 doi "https://doi.org/10.1002/jps.21292" @default.
- W1991536280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18228596" @default.
- W1991536280 hasPublicationYear "2008" @default.
- W1991536280 type Work @default.
- W1991536280 sameAs 1991536280 @default.
- W1991536280 citedByCount "16" @default.
- W1991536280 countsByYear W19915362802012 @default.
- W1991536280 countsByYear W19915362802015 @default.
- W1991536280 countsByYear W19915362802016 @default.
- W1991536280 countsByYear W19915362802018 @default.
- W1991536280 countsByYear W19915362802019 @default.
- W1991536280 countsByYear W19915362802020 @default.
- W1991536280 countsByYear W19915362802023 @default.
- W1991536280 crossrefType "journal-article" @default.
- W1991536280 hasAuthorship W1991536280A5006606585 @default.
- W1991536280 hasAuthorship W1991536280A5006674934 @default.
- W1991536280 hasAuthorship W1991536280A5012454280 @default.
- W1991536280 hasAuthorship W1991536280A5020162492 @default.
- W1991536280 hasAuthorship W1991536280A5020960555 @default.
- W1991536280 hasAuthorship W1991536280A5035169036 @default.
- W1991536280 hasAuthorship W1991536280A5076982441 @default.
- W1991536280 hasConcept C121332964 @default.
- W1991536280 hasConcept C122865956 @default.
- W1991536280 hasConcept C127413603 @default.
- W1991536280 hasConcept C13965031 @default.
- W1991536280 hasConcept C155574463 @default.
- W1991536280 hasConcept C159985019 @default.
- W1991536280 hasConcept C178790620 @default.
- W1991536280 hasConcept C185592680 @default.
- W1991536280 hasConcept C188027245 @default.
- W1991536280 hasConcept C192562407 @default.
- W1991536280 hasConcept C2778805482 @default.
- W1991536280 hasConcept C2781448156 @default.
- W1991536280 hasConcept C39519442 @default.
- W1991536280 hasConcept C41625074 @default.
- W1991536280 hasConcept C42360764 @default.
- W1991536280 hasConcept C50670333 @default.
- W1991536280 hasConcept C521977710 @default.
- W1991536280 hasConcept C55493867 @default.
- W1991536280 hasConcept C58968531 @default.
- W1991536280 hasConcept C88380143 @default.
- W1991536280 hasConcept C97355855 @default.
- W1991536280 hasConceptScore W1991536280C121332964 @default.
- W1991536280 hasConceptScore W1991536280C122865956 @default.
- W1991536280 hasConceptScore W1991536280C127413603 @default.
- W1991536280 hasConceptScore W1991536280C13965031 @default.
- W1991536280 hasConceptScore W1991536280C155574463 @default.
- W1991536280 hasConceptScore W1991536280C159985019 @default.
- W1991536280 hasConceptScore W1991536280C178790620 @default.