FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991541076> ?p ?o ?g. }

• W1991541076 endingPage "2951" @default.
• W1991541076 startingPage "2943" @default.
• W1991541076 abstract "Preexposure prophylaxis (PrEP) with tenofovir and emtricitabine can prevent new HIV-1 infections, but there is a concern that use of PrEP could increase HIV drug resistance resulting in loss of treatment options. We compared standardized outcomes from three independent mathematical models simulating the impact of PrEP on HIV transmission and drug resistance in sub-Saharan African countries.All models assume that people using PrEP receive an HIV test every 3-6 months. The models vary in structure and parameter choices for PrEP coverage, effectiveness of PrEP (at different adherence levels) and the rate with which HIV drug resistance emerges and is transmitted.The models predict that the use of PrEP in conjunction with antiretroviral therapy will result in a lower prevalence of HIV than when only antiretroviral therapy is used. With or without PrEP, all models suggest that HIV drug resistance will increase over the next 20 years due to antiretroviral therapy. PrEP will increase the absolute prevalence of drug resistance in the total population by less than 0.5% and amongst infected individuals by at most 7%. Twenty years after the introduction of PrEP, the majority of drug-resistant infections is due to antiretroviral therapy (50-63% across models), whereas 40-50% will be due to transmission of drug resistance, and less than 4% to the use of PrEP.HIV drug resistance resulting from antiretroviral therapy is predicted to far exceed that resulting from PrEP. Concern over drug resistance should not be a reason to limit the use of PrEP." @default.
• W1991541076 created "2016-06-24" @default.
• W1991541076 creator A5016397813 @default.
• W1991541076 creator A5016768242 @default.
• W1991541076 creator A5033519595 @default.
• W1991541076 creator A5038307269 @default.
• W1991541076 creator A5048537587 @default.
• W1991541076 creator A5049874690 @default.
• W1991541076 creator A5065647297 @default.
• W1991541076 creator A5073812723 @default.
• W1991541076 creator A5084575089 @default.
• W1991541076 creator A5090088811 @default.
• W1991541076 creator A5091531408 @default.
• W1991541076 creator A5091815735 @default.
• W1991541076 date "2013-11-28" @default.
• W1991541076 modified "2023-10-14" @default.
• W1991541076 title "Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa" @default.
• W1991541076 cites W1841532711 @default.
• W1991541076 cites W1982600050 @default.
• W1991541076 cites W2006389041 @default.
• W1991541076 cites W2016682266 @default.
• W1991541076 cites W2038369742 @default.
• W1991541076 cites W2045871034 @default.
• W1991541076 cites W2046584457 @default.
• W1991541076 cites W2062388675 @default.
• W1991541076 cites W2067241941 @default.
• W1991541076 cites W2083226492 @default.
• W1991541076 cites W2084273391 @default.
• W1991541076 cites W2097245338 @default.
• W1991541076 cites W2098100768 @default.
• W1991541076 cites W2103920597 @default.
• W1991541076 cites W2112791146 @default.
• W1991541076 cites W2117057469 @default.
• W1991541076 cites W2119254819 @default.
• W1991541076 cites W2120293408 @default.
• W1991541076 cites W2123519394 @default.
• W1991541076 cites W2135466424 @default.
• W1991541076 cites W2139311359 @default.
• W1991541076 cites W2152505869 @default.
• W1991541076 cites W2157402310 @default.
• W1991541076 cites W2159263888 @default.
• W1991541076 cites W2161961104 @default.
• W1991541076 cites W2162226934 @default.
• W1991541076 cites W2163036286 @default.
• W1991541076 cites W2163912123 @default.
• W1991541076 cites W2168251450 @default.
• W1991541076 cites W2314461521 @default.
• W1991541076 doi "https://doi.org/10.1097/01.aids.0000433237.63560.20" @default.
• W1991541076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23939237" @default.
• W1991541076 hasPublicationYear "2013" @default.
• W1991541076 type Work @default.
• W1991541076 sameAs 1991541076 @default.
• W1991541076 citedByCount "63" @default.
• W1991541076 countsByYear W19915410762014 @default.
• W1991541076 countsByYear W19915410762015 @default.
• W1991541076 countsByYear W19915410762016 @default.
• W1991541076 countsByYear W19915410762017 @default.
• W1991541076 countsByYear W19915410762018 @default.
• W1991541076 countsByYear W19915410762019 @default.
• W1991541076 countsByYear W19915410762020 @default.
• W1991541076 countsByYear W19915410762021 @default.
• W1991541076 countsByYear W19915410762023 @default.
• W1991541076 crossrefType "journal-article" @default.
• W1991541076 hasAuthorship W1991541076A5016397813 @default.
• W1991541076 hasAuthorship W1991541076A5016768242 @default.
• W1991541076 hasAuthorship W1991541076A5033519595 @default.
• W1991541076 hasAuthorship W1991541076A5038307269 @default.
• W1991541076 hasAuthorship W1991541076A5048537587 @default.
• W1991541076 hasAuthorship W1991541076A5049874690 @default.
• W1991541076 hasAuthorship W1991541076A5065647297 @default.
• W1991541076 hasAuthorship W1991541076A5073812723 @default.
• W1991541076 hasAuthorship W1991541076A5084575089 @default.
• W1991541076 hasAuthorship W1991541076A5090088811 @default.
• W1991541076 hasAuthorship W1991541076A5091531408 @default.
• W1991541076 hasAuthorship W1991541076A5091815735 @default.
• W1991541076 hasConcept C114851261 @default.
• W1991541076 hasConcept C119599485 @default.
• W1991541076 hasConcept C127413603 @default.
• W1991541076 hasConcept C142462285 @default.
• W1991541076 hasConcept C159047783 @default.
• W1991541076 hasConcept C2776939746 @default.
• W1991541076 hasConcept C2776983459 @default.
• W1991541076 hasConcept C2778451633 @default.
• W1991541076 hasConcept C2779496540 @default.
• W1991541076 hasConcept C2779778239 @default.
• W1991541076 hasConcept C2780035454 @default.
• W1991541076 hasConcept C2908647359 @default.
• W1991541076 hasConcept C2993143319 @default.
• W1991541076 hasConcept C3013748606 @default.
• W1991541076 hasConcept C3018457394 @default.
• W1991541076 hasConcept C71924100 @default.
• W1991541076 hasConcept C761482 @default.
• W1991541076 hasConcept C86803240 @default.
• W1991541076 hasConcept C89423630 @default.
• W1991541076 hasConcept C98274493 @default.
• W1991541076 hasConcept C99454951 @default.
• W1991541076 hasConceptScore W1991541076C114851261 @default.
• W1991541076 hasConceptScore W1991541076C119599485 @default.

• next