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- W1991544825 abstract "Two-photon spectral resolved imaging was used to image fresh human biopsies of colon tissue and to characterize healthy colon mucosa, adenomatous polyp and adenocarcinoma by means of a morpho-functional analysis. Morphological examination, performed using endogenous tissue fluorescence, discriminated adenomatous and adenocarcinoma tissues from normal mucosa in terms of cellular asymmetry and nucleus-to-cytoplasm ratio. Good agreement was found between multiphoton images and histological examination performed on the same samples. Further characterization, performed by means of spectral-resolved analysis of NADH and FAD fluorescence, demonstrated an altered metabolic activity in both adenomatous and adenocarcinoma tissues compared to healthy mucosa. This morpho-functional approach may represent a powerful method to be used in combination with endoscopy for in vivo optical diagnosis of colon cancer and may be extended to other tissues." @default.
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- W1991544825 date "2013-06-24" @default.
- W1991544825 modified "2023-10-16" @default.
- W1991544825 title "Multiphoton morpho-functional imaging of healthy colon mucosa, adenomatous polyp and adenocarcinoma" @default.
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- W1991544825 doi "https://doi.org/10.1364/boe.4.001204" @default.
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