FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991546805> ?p ?o ?g. }

• W1991546805 endingPage "278" @default.
• W1991546805 startingPage "271" @default.
• W1991546805 abstract "Many hormones and neurotransmitters raise intracellular calcium (Ca(2+)) by generating InsP(3) and activating the inositol 1,4, 5-trisphosphate receptor (InsP(3)R). Multiple isoforms with distinct InsP(3) binding properties () have been identified (). The type III InsP(3)R lacks Ca(2+)-dependent inhibition, a property that makes it ideal for signal initiation (). Regulation of the type III InsP(3)R by InsP(3) and ATP was explored in detail using planar lipid bilayers. In comparison to the type I InsP(3)R, the type III InsP(3)R required a higher concentration of InsP(3) to reach maximal channel activity (EC(50) of 3.2 microM versus 0.5 microM for the types III and I InsP(3)R, respectively). However, the type III InsP(3)R did reach a 2.5-fold higher level of activity. Although activation by InsP(3) was isoform-specific, regulation by ATP was similar for both isoforms. In the presence of 2 microM InsP(3), low ATP concentrations (<6 mM) increased the open probability and mean open time. High ATP concentrations (>6 mM) decreased channel activity. These results illustrate the complex nature of type III InsP(3)R regulation. Enhanced channel activity in the presence of high InsP(3) may be important during periods of prolonged stimulation, whereas allosteric modulation by ATP may help to modulate intracellular Ca(2+) signaling." @default.
• W1991546805 created "2016-06-24" @default.
• W1991546805 creator A5051345847 @default.
• W1991546805 creator A5062088796 @default.
• W1991546805 date "2000-07-01" @default.
• W1991546805 modified "2023-10-17" @default.
• W1991546805 title "Regulation of the Type III InsP3 Receptor by InsP3 and ATP" @default.
• W1991546805 cites W1156084614 @default.
• W1991546805 cites W135766646 @default.
• W1991546805 cites W1519110908 @default.
• W1991546805 cites W1539592459 @default.
• W1991546805 cites W1543977144 @default.
• W1991546805 cites W1547461551 @default.
• W1991546805 cites W154904764 @default.
• W1991546805 cites W1569542125 @default.
• W1991546805 cites W1585949905 @default.
• W1991546805 cites W1586746737 @default.
• W1991546805 cites W1587138541 @default.
• W1991546805 cites W1626869678 @default.
• W1991546805 cites W1661761832 @default.
• W1991546805 cites W1724440031 @default.
• W1991546805 cites W1729732610 @default.
• W1991546805 cites W1806089348 @default.
• W1991546805 cites W1969294498 @default.
• W1991546805 cites W1973646870 @default.
• W1991546805 cites W1976746355 @default.
• W1991546805 cites W1980166477 @default.
• W1991546805 cites W1984843607 @default.
• W1991546805 cites W1989105619 @default.
• W1991546805 cites W1997778815 @default.
• W1991546805 cites W1997816574 @default.
• W1991546805 cites W2008726042 @default.
• W1991546805 cites W2009225377 @default.
• W1991546805 cites W2011786631 @default.
• W1991546805 cites W2012485812 @default.
• W1991546805 cites W2018696172 @default.
• W1991546805 cites W2018973124 @default.
• W1991546805 cites W2021094409 @default.
• W1991546805 cites W2021847777 @default.
• W1991546805 cites W2028656069 @default.
• W1991546805 cites W2029169169 @default.
• W1991546805 cites W2033819296 @default.
• W1991546805 cites W2036145275 @default.
• W1991546805 cites W2047106546 @default.
• W1991546805 cites W2047747233 @default.
• W1991546805 cites W2048682543 @default.
• W1991546805 cites W2058746178 @default.
• W1991546805 cites W2060802834 @default.
• W1991546805 cites W2061014404 @default.
• W1991546805 cites W2066030442 @default.
• W1991546805 cites W2080027694 @default.
• W1991546805 cites W2082722322 @default.
• W1991546805 cites W2085586163 @default.
• W1991546805 cites W2091368852 @default.
• W1991546805 cites W2091444057 @default.
• W1991546805 cites W2100688704 @default.
• W1991546805 cites W2108411628 @default.
• W1991546805 cites W2118559747 @default.
• W1991546805 cites W2125597366 @default.
• W1991546805 cites W2136189765 @default.
• W1991546805 cites W2146387077 @default.
• W1991546805 cites W2150396353 @default.
• W1991546805 cites W2150991652 @default.
• W1991546805 cites W2156579440 @default.
• W1991546805 cites W2163248783 @default.
• W1991546805 cites W2164872793 @default.
• W1991546805 cites W2166691490 @default.
• W1991546805 cites W2167470358 @default.
• W1991546805 cites W2170006809 @default.
• W1991546805 cites W2341142242 @default.
• W1991546805 cites W2343089691 @default.
• W1991546805 cites W2414491104 @default.
• W1991546805 cites W264835993 @default.
• W1991546805 cites W4249424055 @default.
• W1991546805 cites W54107245 @default.
• W1991546805 cites W76629885 @default.
• W1991546805 doi "https://doi.org/10.1016/s0006-3495(00)76289-8" @default.
• W1991546805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1300931" @default.
• W1991546805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10866953" @default.
• W1991546805 hasPublicationYear "2000" @default.
• W1991546805 type Work @default.
• W1991546805 sameAs 1991546805 @default.
• W1991546805 citedByCount "52" @default.
• W1991546805 countsByYear W19915468052012 @default.
• W1991546805 countsByYear W19915468052013 @default.
• W1991546805 countsByYear W19915468052014 @default.
• W1991546805 countsByYear W19915468052017 @default.
• W1991546805 countsByYear W19915468052019 @default.
• W1991546805 countsByYear W19915468052021 @default.
• W1991546805 countsByYear W19915468052022 @default.
• W1991546805 crossrefType "journal-article" @default.
• W1991546805 hasAuthorship W1991546805A5051345847 @default.
• W1991546805 hasAuthorship W1991546805A5062088796 @default.
• W1991546805 hasBestOaLocation W19915468051 @default.
• W1991546805 hasConcept C104317684 @default.
• W1991546805 hasConcept C12554922 @default.
• W1991546805 hasConcept C134018914 @default.
• W1991546805 hasConcept C166342909 @default.

• next