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- W1991547823 abstract "Tri- and tetrapeptides with C-terminal 1-amino-1-cycloalkanecarboxylic acid of the general formula X-Ala-Y-OR, where X is Ala, Leu, Phe, Ac-Tyr, Gly-Pro, Ac-Leu-Lys or Ac-Leu-Arg, Y is Acb, Acp or Ach, and R is methyl or ethyl, have been prepared. These peptides containing a rationally chosen N-substituent are cleaved with a suitable enzyme (leucinaminopeptidase, alaninaminopeptidase, chymotrypsin, plasmin or kallikrein) in an aqueous medium. The arising C-terminal dipeptide ester undergoes spontaneous cyclization to give biologically active spirocyclic dipeptide. The prepared short peptides exhibit all functional features of prodrugs." @default.
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- W1991547823 date "1992-01-01" @default.
- W1991547823 modified "2023-09-23" @default.
- W1991547823 title "Linear Tri- and Tetrapeptides Acting as Prodrugs" @default.
- W1991547823 doi "https://doi.org/10.1135/cccc19920179" @default.
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