FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991558584> ?p ?o ?g. }

• W1991558584 endingPage "75" @default.
• W1991558584 startingPage "68" @default.
• W1991558584 abstract "There is enormous clinical potential in exploiting the spatial and temporal resolution of optical techniques to modulate pathophysiological neuronal activity, especially intractable focal epilepsy. We have recently utilized a new ruthenium-based caged compound, ruthenium-bipyridine-triphenylphosphine-γ-aminobutyric acid (RuBi-GABA), which releases GABA when exposed to blue light, to rapidly terminate paroxysmal activity in vitro and in vivo.The convulsant 4-aminopyridine was used to induce interictal activity and seizures in rat neocortical slices and anesthetized rats. We examined the effect of blue light, generated by a small, light-emitting diode (LED), on the frequency and duration of ictal activity in the presence and absence of RuBi-GABA.Neither blue light alone, nor low concentrations of RuBi-GABA, affected interictal activity or baseline electrical activity in neocortical slices. However, brief, blue illumination of RuBi-GABA, using our LED, dramatically reduced extracellular spikes and bursts. More impressively, illumination of locally applied RuBi-GABA rapidly terminated in vivo seizures induced by topical application of 4-aminopyridine. The RuBi-GABA effect was blocked by the GABA(A) antagonist picrotoxin, but not duplicated by direct application of GABA.This is the first example of optical control of in vivo epilepsy, proving that there is sufficient cortical light penetration from an LED and diffusion of caged GABA to quickly terminate intense focal seizures. We are aware that many obstacles need to be overcome before this technique can be translated to patients, but at the moment, this represents a feasible method for harnessing optical techniques to fabricate an implantable device for the therapy of neocortical epilepsy." @default.
• W1991558584 created "2016-06-24" @default.
• W1991558584 creator A5011589908 @default.
• W1991558584 creator A5012596553 @default.
• W1991558584 creator A5020294559 @default.
• W1991558584 creator A5080785007 @default.
• W1991558584 creator A5083888813 @default.
• W1991558584 date "2012-01-01" @default.
• W1991558584 modified "2023-09-27" @default.
• W1991558584 title "Optical control of focal epilepsy in vivo with caged γ-aminobutyric acid" @default.
• W1991558584 cites W1542020233 @default.
• W1991558584 cites W1909177474 @default.
• W1991558584 cites W2005104169 @default.
• W1991558584 cites W2009253761 @default.
• W1991558584 cites W2016321438 @default.
• W1991558584 cites W2018990456 @default.
• W1991558584 cites W2024561575 @default.
• W1991558584 cites W2027924168 @default.
• W1991558584 cites W2029144110 @default.
• W1991558584 cites W2032805218 @default.
• W1991558584 cites W2034488554 @default.
• W1991558584 cites W2036908864 @default.
• W1991558584 cites W2064727978 @default.
• W1991558584 cites W2083058184 @default.
• W1991558584 cites W2106932601 @default.
• W1991558584 cites W2134456995 @default.
• W1991558584 cites W2135629133 @default.
• W1991558584 cites W2138797652 @default.
• W1991558584 cites W2147570569 @default.
• W1991558584 cites W2157002015 @default.
• W1991558584 cites W2159772550 @default.
• W1991558584 cites W2167993924 @default.
• W1991558584 cites W2171509705 @default.
• W1991558584 doi "https://doi.org/10.1002/ana.22596" @default.
• W1991558584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4133113" @default.
• W1991558584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22275253" @default.
• W1991558584 hasPublicationYear "2012" @default.
• W1991558584 type Work @default.
• W1991558584 sameAs 1991558584 @default.
• W1991558584 citedByCount "24" @default.
• W1991558584 countsByYear W19915585842012 @default.
• W1991558584 countsByYear W19915585842013 @default.
• W1991558584 countsByYear W19915585842014 @default.
• W1991558584 countsByYear W19915585842015 @default.
• W1991558584 countsByYear W19915585842016 @default.
• W1991558584 countsByYear W19915585842017 @default.
• W1991558584 countsByYear W19915585842018 @default.
• W1991558584 countsByYear W19915585842019 @default.
• W1991558584 countsByYear W19915585842020 @default.
• W1991558584 countsByYear W19915585842021 @default.
• W1991558584 countsByYear W19915585842022 @default.
• W1991558584 crossrefType "journal-article" @default.
• W1991558584 hasAuthorship W1991558584A5011589908 @default.
• W1991558584 hasAuthorship W1991558584A5012596553 @default.
• W1991558584 hasAuthorship W1991558584A5020294559 @default.
• W1991558584 hasAuthorship W1991558584A5080785007 @default.
• W1991558584 hasAuthorship W1991558584A5083888813 @default.
• W1991558584 hasBestOaLocation W19915585842 @default.
• W1991558584 hasConcept C12554922 @default.
• W1991558584 hasConcept C150903083 @default.
• W1991558584 hasConcept C168258287 @default.
• W1991558584 hasConcept C169760540 @default.
• W1991558584 hasConcept C170493617 @default.
• W1991558584 hasConcept C17755696 @default.
• W1991558584 hasConcept C185592680 @default.
• W1991558584 hasConcept C207001950 @default.
• W1991558584 hasConcept C2778186239 @default.
• W1991558584 hasConcept C2778900099 @default.
• W1991558584 hasConcept C2779324764 @default.
• W1991558584 hasConcept C2780763569 @default.
• W1991558584 hasConcept C55493867 @default.
• W1991558584 hasConcept C79636183 @default.
• W1991558584 hasConcept C86803240 @default.
• W1991558584 hasConceptScore W1991558584C12554922 @default.
• W1991558584 hasConceptScore W1991558584C150903083 @default.
• W1991558584 hasConceptScore W1991558584C168258287 @default.
• W1991558584 hasConceptScore W1991558584C169760540 @default.
• W1991558584 hasConceptScore W1991558584C170493617 @default.
• W1991558584 hasConceptScore W1991558584C17755696 @default.
• W1991558584 hasConceptScore W1991558584C185592680 @default.
• W1991558584 hasConceptScore W1991558584C207001950 @default.
• W1991558584 hasConceptScore W1991558584C2778186239 @default.
• W1991558584 hasConceptScore W1991558584C2778900099 @default.
• W1991558584 hasConceptScore W1991558584C2779324764 @default.
• W1991558584 hasConceptScore W1991558584C2780763569 @default.
• W1991558584 hasConceptScore W1991558584C55493867 @default.
• W1991558584 hasConceptScore W1991558584C79636183 @default.
• W1991558584 hasConceptScore W1991558584C86803240 @default.
• W1991558584 hasIssue "1" @default.
• W1991558584 hasLocation W19915585841 @default.
• W1991558584 hasLocation W19915585842 @default.
• W1991558584 hasLocation W19915585843 @default.
• W1991558584 hasLocation W19915585844 @default.
• W1991558584 hasOpenAccess W1991558584 @default.
• W1991558584 hasPrimaryLocation W19915585841 @default.
• W1991558584 hasRelatedWork W1967638696 @default.
• W1991558584 hasRelatedWork W1973523146 @default.
• W1991558584 hasRelatedWork W1990627463 @default.

• next