FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991565364> ?p ?o ?g. }

• W1991565364 endingPage "236" @default.
• W1991565364 startingPage "229" @default.
• W1991565364 abstract "The enzyme heme oxygenase-1 (HO-1) exerts cytoprotective effects in response to various cellular stressors. A variable number tandem repeat polymorphism in the HO-1 gene promoter region has previously been linked to cardiovascular disease. We examined this association prospectively in the general population.Incidence of stroke, myocardial infarction, or vascular death was registered between 1995 and 2010 in 812 participants of the Bruneck Study aged 45 to 84 years (49.4% males). Carotid atherosclerosis progression was quantified by high-resolution ultrasound. HO-1 variable number tandem repeat length was determined by polymerase chain reaction. Subjects with ≥32 tandem repeats on both HO-1 alleles compared with the rest of the population (recessive trait) featured substantially increased cardiovascular disease risk (hazard ratio [95% confidence interval], 5.45 [2.39, 12.42]; P<0.0001), enhanced atherosclerosis progression (median difference in atherosclerosis score [interquartile range], 2.1 [0.8, 5.6] versus 0.0 [0.0, 2.2] mm; P=0.0012), and a trend toward higher levels of oxidized phospholipids on apolipoprotein B-100 (median oxidized phospholipids/apolipoprotein B level [interquartile range], 11364 [4160, 18330] versus 4844 [3174, 12284] relative light units; P=0.0554). Increased cardiovascular disease risk in those homozygous for ≥32 repeats was also detected in a pooled analysis of 7848 participants of the Bruneck, SAPHIR, and KORA prospective studies (hazard ratio [95% confidence interval], 3.26 [1.50, 7.33]; P=0.0043).This study found a strong association between the HO-1 variable number tandem repeat polymorphism and cardiovascular disease risk confined to subjects with a high number of repeats on both HO-1 alleles and provides evidence for accelerated atherogenesis and decreased antioxidant defense in this vascular high-risk group." @default.
• W1991565364 created "2016-06-24" @default.
• W1991565364 creator A5000984193 @default.
• W1991565364 creator A5003195037 @default.
• W1991565364 creator A5009628835 @default.
• W1991565364 creator A5012116390 @default.
• W1991565364 creator A5013372392 @default.
• W1991565364 creator A5013646248 @default.
• W1991565364 creator A5014832788 @default.
• W1991565364 creator A5016157487 @default.
• W1991565364 creator A5025058942 @default.
• W1991565364 creator A5027705443 @default.
• W1991565364 creator A5030001856 @default.
• W1991565364 creator A5036197337 @default.
• W1991565364 creator A5037079092 @default.
• W1991565364 creator A5037779272 @default.
• W1991565364 creator A5041864981 @default.
• W1991565364 creator A5044689174 @default.
• W1991565364 creator A5058520172 @default.
• W1991565364 creator A5080567842 @default.
• W1991565364 creator A5082464365 @default.
• W1991565364 creator A5085407328 @default.
• W1991565364 creator A5091030211 @default.
• W1991565364 date "2015-01-01" @default.
• W1991565364 modified "2023-10-10" @default.
• W1991565364 title "Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism Is Associated With Progressive Atherosclerosis and Incident Cardiovascular Disease" @default.
• W1991565364 cites W1528925569 @default.
• W1991565364 cites W173951409 @default.
• W1991565364 cites W1963514532 @default.
• W1991565364 cites W2002217214 @default.
• W1991565364 cites W2005904261 @default.
• W1991565364 cites W2008737276 @default.
• W1991565364 cites W2025107286 @default.
• W1991565364 cites W2032159980 @default.
• W1991565364 cites W2048834825 @default.
• W1991565364 cites W2059625939 @default.
• W1991565364 cites W2064063264 @default.
• W1991565364 cites W2070245549 @default.
• W1991565364 cites W2075251523 @default.
• W1991565364 cites W2083858344 @default.
• W1991565364 cites W2086805237 @default.
• W1991565364 cites W2092479473 @default.
• W1991565364 cites W2094774474 @default.
• W1991565364 cites W2106357843 @default.
• W1991565364 cites W2119855284 @default.
• W1991565364 cites W2120505405 @default.
• W1991565364 cites W2125127136 @default.
• W1991565364 cites W2134360290 @default.
• W1991565364 cites W2135103569 @default.
• W1991565364 cites W2144630241 @default.
• W1991565364 cites W2147077841 @default.
• W1991565364 cites W2149167244 @default.
• W1991565364 cites W2154276482 @default.
• W1991565364 cites W2156570713 @default.
• W1991565364 cites W2156695570 @default.
• W1991565364 cites W2169259020 @default.
• W1991565364 cites W2324841714 @default.
• W1991565364 cites W2334499790 @default.
• W1991565364 doi "https://doi.org/10.1161/atvbaha.114.304729" @default.
• W1991565364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4317265" @default.
• W1991565364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25359861" @default.
• W1991565364 hasPublicationYear "2015" @default.
• W1991565364 type Work @default.
• W1991565364 sameAs 1991565364 @default.
• W1991565364 citedByCount "49" @default.
• W1991565364 countsByYear W19915653642015 @default.
• W1991565364 countsByYear W19915653642016 @default.
• W1991565364 countsByYear W19915653642017 @default.
• W1991565364 countsByYear W19915653642018 @default.
• W1991565364 countsByYear W19915653642019 @default.
• W1991565364 countsByYear W19915653642020 @default.
• W1991565364 countsByYear W19915653642021 @default.
• W1991565364 countsByYear W19915653642022 @default.
• W1991565364 countsByYear W19915653642023 @default.
• W1991565364 crossrefType "journal-article" @default.
• W1991565364 hasAuthorship W1991565364A5000984193 @default.
• W1991565364 hasAuthorship W1991565364A5003195037 @default.
• W1991565364 hasAuthorship W1991565364A5009628835 @default.
• W1991565364 hasAuthorship W1991565364A5012116390 @default.
• W1991565364 hasAuthorship W1991565364A5013372392 @default.
• W1991565364 hasAuthorship W1991565364A5013646248 @default.
• W1991565364 hasAuthorship W1991565364A5014832788 @default.
• W1991565364 hasAuthorship W1991565364A5016157487 @default.
• W1991565364 hasAuthorship W1991565364A5025058942 @default.
• W1991565364 hasAuthorship W1991565364A5027705443 @default.
• W1991565364 hasAuthorship W1991565364A5030001856 @default.
• W1991565364 hasAuthorship W1991565364A5036197337 @default.
• W1991565364 hasAuthorship W1991565364A5037079092 @default.
• W1991565364 hasAuthorship W1991565364A5037779272 @default.
• W1991565364 hasAuthorship W1991565364A5041864981 @default.
• W1991565364 hasAuthorship W1991565364A5044689174 @default.
• W1991565364 hasAuthorship W1991565364A5058520172 @default.
• W1991565364 hasAuthorship W1991565364A5080567842 @default.
• W1991565364 hasAuthorship W1991565364A5082464365 @default.
• W1991565364 hasAuthorship W1991565364A5085407328 @default.
• W1991565364 hasAuthorship W1991565364A5091030211 @default.
• W1991565364 hasBestOaLocation W19915653641 @default.
• W1991565364 hasConcept C104317684 @default.

• next