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- W1991567486 abstract "Abstract In order to determine the minimal amount of dietary 9‐ trans ,12‐ trans ‐linoleate which can decrease endoperoxide metabolites synthesized and their precursor in rat platelets, graded amounts (0, 0.1, 0.5, 1.0, 2.5%) of the trans ‐linoleate were fed to rats with a constant amount of all‐ cis ‐linoleate (2.5%) for 12 weeks. Arachidonic acid levels in platelet phospholipids of groups receiving the trans ‐linoleate at 2.5 and 1.0% were significantly (p<0.01) lower than that of the control receiving no trans ‐linoleate. Concentrations of TXB 2 and PGF 2α in sera of the group receiving 2.5% trans ‐linoleate were significantly (p<0.05) lower than those of the control; however, there was no difference between the group receiving 1.0% trans ‐linoleate and the control. To determine whether the difference in serum concentrations of endoperoxide metabolites could be manifested if rats were fed for longer period of time, 2 groups of rats were again fed diets containing 0 and 1.0% trans ‐linoleate, respectively, for 16 weeks. Arachidonic acid in platelet phospholipids of the group receiving the trans ‐linoleate was again significantly (p<0.01) lower than that of the control group. Concentrations of TXB 2 and PGF 2α , and 12‐hydroxyeicosatetraenoic acid formed in platelets, were smaller in the group receiving trans ‐linoleate than the control group; however, the difference was not statistically significant. These results indicated that all‐ trans ‐linoleate can reduce arachidonic acid metabolites formed in rat platelets when its dietary level is equal to or exceeds the level of all‐ cis ‐linoeate." @default.
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- W1991567486 date "1982-04-01" @default.
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- W1991567486 title "Effects of dietary 9-trans, 12-trans linoleate on arachidonic acid metabolism in rat platelets" @default.
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- W1991567486 doi "https://doi.org/10.1007/bf02534946" @default.
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