Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991569089> ?p ?o ?g. }
- W1991569089 endingPage "10633" @default.
- W1991569089 startingPage "10625" @default.
- W1991569089 abstract "ABSTRACT The human pathogenic poxvirus molluscum contagiosum virus (MCV) is the causative agent of benign neoplasm, with worldwide incidence, characterized by intraepidermal hyperplasia and hypertrophy of cells. Here, we present evidence that the MC007L protein of MCV targets retinoblastoma protein (pRb) via a conserved LxCxE motif, which is present in many viral oncoproteins. The deregulation of the pRb pathway plays a central role in tumor pathogenesis. The oncoproteins of small DNA viruses contain amino acid sequences that bind to and inactivate pRb. Isolated expression of these oncoproteins induces apoptosis, cell proliferation, and cellular transformation. The MC007L gene displays no homology to other genes within the poxvirus family. The protein anchors into the outer mitochondrial membrane via an N-terminal mitochondrial targeting sequence. Through the LxCxE motifs, MC007L induces a cytosolic sequestration of pRb at mitochondrial membranes, leading to the inactivation of the protein by mislocalization. MC007L precipitates the endogenous pRb/E2F-1 complex. Moreover, MC007L is able to cooperate to transform primary rat kidney cells. The interaction between MC007L and pRb provides a novel mechanism by which a virus can perturb the cell cycle." @default.
- W1991569089 created "2016-06-24" @default.
- W1991569089 creator A5014137681 @default.
- W1991569089 creator A5021776423 @default.
- W1991569089 creator A5027394856 @default.
- W1991569089 creator A5039158164 @default.
- W1991569089 creator A5053024064 @default.
- W1991569089 creator A5061855498 @default.
- W1991569089 creator A5074224711 @default.
- W1991569089 creator A5083824702 @default.
- W1991569089 date "2008-11-01" @default.
- W1991569089 modified "2023-10-14" @default.
- W1991569089 title "Targeting the Retinoblastoma Protein by MC007L, Gene Product of the Molluscum Contagiosum Virus: Detection of a Novel Virus-Cell Interaction by a Member of the Poxviruses" @default.
- W1991569089 cites W1512653355 @default.
- W1991569089 cites W152013658 @default.
- W1991569089 cites W1532255632 @default.
- W1991569089 cites W1929453134 @default.
- W1991569089 cites W1948709514 @default.
- W1991569089 cites W1957295278 @default.
- W1991569089 cites W1967391544 @default.
- W1991569089 cites W1967404701 @default.
- W1991569089 cites W1978121808 @default.
- W1991569089 cites W1990105092 @default.
- W1991569089 cites W1999330214 @default.
- W1991569089 cites W2005288281 @default.
- W1991569089 cites W2008005699 @default.
- W1991569089 cites W2018646351 @default.
- W1991569089 cites W2018753467 @default.
- W1991569089 cites W2028171330 @default.
- W1991569089 cites W2032741238 @default.
- W1991569089 cites W2035909451 @default.
- W1991569089 cites W2045898134 @default.
- W1991569089 cites W2047664746 @default.
- W1991569089 cites W2058786792 @default.
- W1991569089 cites W2064241321 @default.
- W1991569089 cites W2072451099 @default.
- W1991569089 cites W2073978079 @default.
- W1991569089 cites W2078066154 @default.
- W1991569089 cites W2084010667 @default.
- W1991569089 cites W2097013351 @default.
- W1991569089 cites W2107913200 @default.
- W1991569089 cites W2112915988 @default.
- W1991569089 cites W2113411351 @default.
- W1991569089 cites W2118595974 @default.
- W1991569089 cites W2130412866 @default.
- W1991569089 cites W2130481614 @default.
- W1991569089 cites W2131308181 @default.
- W1991569089 cites W2133831229 @default.
- W1991569089 cites W2146180420 @default.
- W1991569089 cites W2149139293 @default.
- W1991569089 cites W2169537129 @default.
- W1991569089 cites W4242700871 @default.
- W1991569089 cites W4244118502 @default.
- W1991569089 cites W4244580436 @default.
- W1991569089 cites W4246290384 @default.
- W1991569089 cites W4382787168 @default.
- W1991569089 doi "https://doi.org/10.1128/jvi.01187-08" @default.
- W1991569089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573180" @default.
- W1991569089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18701596" @default.
- W1991569089 hasPublicationYear "2008" @default.
- W1991569089 type Work @default.
- W1991569089 sameAs 1991569089 @default.
- W1991569089 citedByCount "16" @default.
- W1991569089 countsByYear W19915690892012 @default.
- W1991569089 countsByYear W19915690892013 @default.
- W1991569089 countsByYear W19915690892015 @default.
- W1991569089 countsByYear W19915690892016 @default.
- W1991569089 countsByYear W19915690892017 @default.
- W1991569089 countsByYear W19915690892019 @default.
- W1991569089 countsByYear W19915690892020 @default.
- W1991569089 countsByYear W19915690892021 @default.
- W1991569089 crossrefType "journal-article" @default.
- W1991569089 hasAuthorship W1991569089A5014137681 @default.
- W1991569089 hasAuthorship W1991569089A5021776423 @default.
- W1991569089 hasAuthorship W1991569089A5027394856 @default.
- W1991569089 hasAuthorship W1991569089A5039158164 @default.
- W1991569089 hasAuthorship W1991569089A5053024064 @default.
- W1991569089 hasAuthorship W1991569089A5061855498 @default.
- W1991569089 hasAuthorship W1991569089A5074224711 @default.
- W1991569089 hasAuthorship W1991569089A5083824702 @default.
- W1991569089 hasBestOaLocation W19915690894 @default.
- W1991569089 hasConcept C104317684 @default.
- W1991569089 hasConcept C153911025 @default.
- W1991569089 hasConcept C159047783 @default.
- W1991569089 hasConcept C2522874641 @default.
- W1991569089 hasConcept C2776062698 @default.
- W1991569089 hasConcept C2780879997 @default.
- W1991569089 hasConcept C29537977 @default.
- W1991569089 hasConcept C54355233 @default.
- W1991569089 hasConcept C86803240 @default.
- W1991569089 hasConcept C95444343 @default.
- W1991569089 hasConceptScore W1991569089C104317684 @default.
- W1991569089 hasConceptScore W1991569089C153911025 @default.
- W1991569089 hasConceptScore W1991569089C159047783 @default.
- W1991569089 hasConceptScore W1991569089C2522874641 @default.
- W1991569089 hasConceptScore W1991569089C2776062698 @default.
- W1991569089 hasConceptScore W1991569089C2780879997 @default.
- W1991569089 hasConceptScore W1991569089C29537977 @default.