FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991569165> ?p ?o ?g. }

• W1991569165 endingPage "615" @default.
• W1991569165 startingPage "606" @default.
• W1991569165 abstract "Microgravity and cosmic rays as found in space are difficult to recreate on earth. However, ground-based models exist to simulate space flight experiments. In the present study, an experimental model was utilized to monitor gene expression changes in fetal skin fibroblasts of murine origin. Cells were continuously subjected for 65 h to a low dose (55 mSv) of ionizing radiation (IR), comprising a mixture of high‑linear energy transfer (LET) neutrons and low-LET gamma-rays, and/or simulated microgravity using the random positioning machine (RPM), after which microarrays were performed. The data were analyzed both by gene set enrichment analysis (GSEA) and single gene analysis (SGA). Simulated microgravity affected fetal murine fibroblasts by inducing oxidative stress responsive genes. Three of these genes are targets of the nuclear factor‑erythroid 2 p45-related factor 2 (Nrf2), which may play a role in the cell response to simulated microgravity. In addition, simulated gravity decreased the expression of genes involved in cytoskeleton remodeling, which may have been caused by the downregulation of the serum response factor (SRF), possibly through the Rho signaling pathway. Similarly, chronic exposure to low-dose IR caused the downregulation of genes involved in cytoskeleton remodeling, as well as in cell cycle regulation and DNA damage response pathways. Many of the genes or gene sets that were altered in the individual treatments (RPM or IR) were not altered in the combined treatment (RPM and IR), indicating a complex interaction between RPM and IR." @default.
• W1991569165 created "2016-06-24" @default.
• W1991569165 creator A5005701700 @default.
• W1991569165 creator A5010190074 @default.
• W1991569165 creator A5029078912 @default.
• W1991569165 creator A5029401139 @default.
• W1991569165 creator A5032132904 @default.
• W1991569165 creator A5047656220 @default.
• W1991569165 creator A5063019315 @default.
• W1991569165 creator A5063366433 @default.
• W1991569165 creator A5065050414 @default.
• W1991569165 creator A5071582648 @default.
• W1991569165 creator A5085500296 @default.
• W1991569165 creator A5089284540 @default.
• W1991569165 date "2014-05-22" @default.
• W1991569165 modified "2023-10-14" @default.
• W1991569165 title "Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts" @default.
• W1991569165 cites W1536811346 @default.
• W1991569165 cites W1967108243 @default.
• W1991569165 cites W1973853894 @default.
• W1991569165 cites W1975589071 @default.
• W1991569165 cites W1977229794 @default.
• W1991569165 cites W1987095853 @default.
• W1991569165 cites W1998041274 @default.
• W1991569165 cites W2007416079 @default.
• W1991569165 cites W2007821852 @default.
• W1991569165 cites W2019731805 @default.
• W1991569165 cites W2022164333 @default.
• W1991569165 cites W2023564624 @default.
• W1991569165 cites W2035625246 @default.
• W1991569165 cites W2043080272 @default.
• W1991569165 cites W2043234599 @default.
• W1991569165 cites W2054874071 @default.
• W1991569165 cites W2056132557 @default.
• W1991569165 cites W2061437659 @default.
• W1991569165 cites W2067011460 @default.
• W1991569165 cites W2075947831 @default.
• W1991569165 cites W2078874082 @default.
• W1991569165 cites W2083960671 @default.
• W1991569165 cites W2085776541 @default.
• W1991569165 cites W2090392605 @default.
• W1991569165 cites W2093584479 @default.
• W1991569165 cites W2102473269 @default.
• W1991569165 cites W2126088744 @default.
• W1991569165 cites W2128155410 @default.
• W1991569165 cites W2130410032 @default.
• W1991569165 cites W2135303383 @default.
• W1991569165 cites W2150064622 @default.
• W1991569165 cites W2153191075 @default.
• W1991569165 cites W2155144124 @default.
• W1991569165 cites W2156289700 @default.
• W1991569165 cites W2168607364 @default.
• W1991569165 cites W2169768109 @default.
• W1991569165 cites W4248277281 @default.
• W1991569165 doi "https://doi.org/10.3892/ijmm.2014.1785" @default.
• W1991569165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24859186" @default.
• W1991569165 hasPublicationYear "2014" @default.
• W1991569165 type Work @default.
• W1991569165 sameAs 1991569165 @default.
• W1991569165 citedByCount "35" @default.
• W1991569165 countsByYear W19915691652014 @default.
• W1991569165 countsByYear W19915691652015 @default.
• W1991569165 countsByYear W19915691652016 @default.
• W1991569165 countsByYear W19915691652017 @default.
• W1991569165 countsByYear W19915691652018 @default.
• W1991569165 countsByYear W19915691652019 @default.
• W1991569165 countsByYear W19915691652020 @default.
• W1991569165 countsByYear W19915691652021 @default.
• W1991569165 countsByYear W19915691652022 @default.
• W1991569165 countsByYear W19915691652023 @default.
• W1991569165 crossrefType "journal-article" @default.
• W1991569165 hasAuthorship W1991569165A5005701700 @default.
• W1991569165 hasAuthorship W1991569165A5010190074 @default.
• W1991569165 hasAuthorship W1991569165A5029078912 @default.
• W1991569165 hasAuthorship W1991569165A5029401139 @default.
• W1991569165 hasAuthorship W1991569165A5032132904 @default.
• W1991569165 hasAuthorship W1991569165A5047656220 @default.
• W1991569165 hasAuthorship W1991569165A5063019315 @default.
• W1991569165 hasAuthorship W1991569165A5063366433 @default.
• W1991569165 hasAuthorship W1991569165A5065050414 @default.
• W1991569165 hasAuthorship W1991569165A5071582648 @default.
• W1991569165 hasAuthorship W1991569165A5085500296 @default.
• W1991569165 hasAuthorship W1991569165A5089284540 @default.
• W1991569165 hasBestOaLocation W19915691651 @default.
• W1991569165 hasConcept C104317684 @default.
• W1991569165 hasConcept C127561419 @default.
• W1991569165 hasConcept C134018914 @default.
• W1991569165 hasConcept C150194340 @default.
• W1991569165 hasConcept C153911025 @default.
• W1991569165 hasConcept C2776151105 @default.
• W1991569165 hasConcept C2781018059 @default.
• W1991569165 hasConcept C29537977 @default.
• W1991569165 hasConcept C54355233 @default.
• W1991569165 hasConcept C86803240 @default.
• W1991569165 hasConcept C95444343 @default.
• W1991569165 hasConceptScore W1991569165C104317684 @default.
• W1991569165 hasConceptScore W1991569165C127561419 @default.
• W1991569165 hasConceptScore W1991569165C134018914 @default.

• next