FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991581523> ?p ?o ?g. }

• W1991581523 abstract "In the adult mammalian brain, neural stem cells (NSCs) proliferate in the dentate gyrus (DG) of the hippocampus and generate new neurons throughout life. A multimodal protein, Galectin-1, is expressed in neural progenitor cells (NPCs) and implicated in the proliferation of the NPCs in the DG. However, little is known about its detailed expression profile in the NPCs and functions in adult neurogenesis in the DG.Our immunohistochemical and morphological analysis showed that Galectin-1 was expressed in the type 1 and 2a cells, which are putative NSCs, in the subgranular zone (SGZ) of the adult mouse DG. To study Galectin-1's function in adult hippocampal neurogenesis, we made galectin-1 knock-out mice on the C57BL6 background and characterized the effects on neurogenesis. In the SGZ of the galectin-1 knock-out mice, increased numbers of type 1 cells, DCX-positive immature progenitors, and NeuN-positive newborn neurons were observed. Using triple-labeling immunohistochemistry and morphological analyses, we found that the proliferation of the type-1 cells was increased in the SGZ of the galectin-1 knock-out mice, and we propose that this proliferation is the mechanism for the net increase in the adult neurogenesis in these knock-out mice DG.Galectin-1 is expressed in the neural stem cells and down-regulates neurogenesis in the adult hippocampus." @default.
• W1991581523 created "2016-06-24" @default.
• W1991581523 creator A5005882177 @default.
• W1991581523 creator A5029176428 @default.
• W1991581523 creator A5030002585 @default.
• W1991581523 creator A5035479034 @default.
• W1991581523 creator A5056430011 @default.
• W1991581523 creator A5059620275 @default.
• W1991581523 creator A5085603616 @default.
• W1991581523 date "2011-01-27" @default.
• W1991581523 modified "2023-10-07" @default.
• W1991581523 title "Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus" @default.
• W1991581523 cites W1540436551 @default.
• W1991581523 cites W1857298428 @default.
• W1991581523 cites W1953286383 @default.
• W1991581523 cites W1970330769 @default.
• W1991581523 cites W1972928390 @default.
• W1991581523 cites W1974791004 @default.
• W1991581523 cites W1977966461 @default.
• W1991581523 cites W1978488532 @default.
• W1991581523 cites W1980286364 @default.
• W1991581523 cites W1980499453 @default.
• W1991581523 cites W1983537937 @default.
• W1991581523 cites W1983955843 @default.
• W1991581523 cites W1997693725 @default.
• W1991581523 cites W2003675111 @default.
• W1991581523 cites W2007671824 @default.
• W1991581523 cites W2009947065 @default.
• W1991581523 cites W2012020530 @default.
• W1991581523 cites W2018657730 @default.
• W1991581523 cites W2022361887 @default.
• W1991581523 cites W2023060626 @default.
• W1991581523 cites W2024357798 @default.
• W1991581523 cites W2026393786 @default.
• W1991581523 cites W2028616351 @default.
• W1991581523 cites W2028740741 @default.
• W1991581523 cites W2032490809 @default.
• W1991581523 cites W2035250926 @default.
• W1991581523 cites W2037701234 @default.
• W1991581523 cites W2046521512 @default.
• W1991581523 cites W2053511665 @default.
• W1991581523 cites W2056999997 @default.
• W1991581523 cites W2057608998 @default.
• W1991581523 cites W2059471650 @default.
• W1991581523 cites W2060922306 @default.
• W1991581523 cites W2062386682 @default.
• W1991581523 cites W2065569210 @default.
• W1991581523 cites W2067856703 @default.
• W1991581523 cites W2091474780 @default.
• W1991581523 cites W2093377540 @default.
• W1991581523 cites W2103752895 @default.
• W1991581523 cites W2116075828 @default.
• W1991581523 cites W2129258790 @default.
• W1991581523 cites W2132164731 @default.
• W1991581523 cites W2132504992 @default.
• W1991581523 cites W2136379343 @default.
• W1991581523 cites W2142349181 @default.
• W1991581523 cites W2143971479 @default.
• W1991581523 cites W2157672076 @default.
• W1991581523 cites W2160023163 @default.
• W1991581523 cites W2406834013 @default.
• W1991581523 doi "https://doi.org/10.1186/1756-6606-4-7" @default.
• W1991581523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3041742" @default.
• W1991581523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21269521" @default.
• W1991581523 hasPublicationYear "2011" @default.
• W1991581523 type Work @default.
• W1991581523 sameAs 1991581523 @default.
• W1991581523 citedByCount "28" @default.
• W1991581523 countsByYear W19915815232012 @default.
• W1991581523 countsByYear W19915815232013 @default.
• W1991581523 countsByYear W19915815232014 @default.
• W1991581523 countsByYear W19915815232015 @default.
• W1991581523 countsByYear W19915815232017 @default.
• W1991581523 countsByYear W19915815232018 @default.
• W1991581523 countsByYear W19915815232019 @default.
• W1991581523 countsByYear W19915815232021 @default.
• W1991581523 countsByYear W19915815232022 @default.
• W1991581523 crossrefType "journal-article" @default.
• W1991581523 hasAuthorship W1991581523A5005882177 @default.
• W1991581523 hasAuthorship W1991581523A5029176428 @default.
• W1991581523 hasAuthorship W1991581523A5030002585 @default.
• W1991581523 hasAuthorship W1991581523A5035479034 @default.
• W1991581523 hasAuthorship W1991581523A5056430011 @default.
• W1991581523 hasAuthorship W1991581523A5059620275 @default.
• W1991581523 hasAuthorship W1991581523A5085603616 @default.
• W1991581523 hasBestOaLocation W19915815231 @default.
• W1991581523 hasConcept C136834591 @default.
• W1991581523 hasConcept C148762608 @default.
• W1991581523 hasConcept C169760540 @default.
• W1991581523 hasConcept C200707615 @default.
• W1991581523 hasConcept C201750760 @default.
• W1991581523 hasConcept C203014093 @default.
• W1991581523 hasConcept C204232928 @default.
• W1991581523 hasConcept C2776464000 @default.
• W1991581523 hasConcept C2777542384 @default.
• W1991581523 hasConcept C2781100881 @default.
• W1991581523 hasConcept C2781161787 @default.
• W1991581523 hasConcept C2781176699 @default.
• W1991581523 hasConcept C2781461022 @default.
• W1991581523 hasConcept C28328180 @default.

• next