Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991586879> ?p ?o ?g. }
- W1991586879 endingPage "677" @default.
- W1991586879 startingPage "665" @default.
- W1991586879 abstract "Alzheimer's disease (AD), a multifactorial neurodegenerative condition caused by genetic and environmental factors, is diagnosed using neuropsychological tests and brain imaging; molecular diagnostics are not routinely applied. Studies have identified AD-specific cerebrospinal fluid (CSF) biomarkers but sample collection requires invasive lumbar puncture. To identify AD-modulated proteins in easily accessible blood platelets, which share biochemical signatures with neurons, we compared platelet lysates from 62 AD, 24 amnestic mild cognitive impairment (aMCI), 13 vascular dementia (VaD), and 12 Parkinson's disease (PD) patients with those of 112 matched controls by fluorescence two-dimensional differential gel electrophoresis in independent discovery and verification sets. The optimal sum score of four mass spectrometry (MS)-identified proteins yielded a sensitivity of 94 % and a specificity of 89 % (AUC = 0.969, 95 % CI = 0.944-0.994) to differentiate AD patients from healthy controls. To bridge the gap between bench and bedside, we developed a high-throughput multiplex protein biochip with great potential for routine AD screening. For convenience and speed of application, this array combines loading control-assisted protein quantification of monoamine oxidase B and tropomyosin 1 with protein-based genotyping for single nucleotide polymorphisms (SNPs) in the apolipoprotein E and glutathione S-transferase omega 1 genes. Based on minimally invasive blood drawing, this innovative protein biochip enables identification of AD patients with an accuracy of 92 % in a single analytical step in less than 4 h." @default.
- W1991586879 created "2016-06-24" @default.
- W1991586879 creator A5002745047 @default.
- W1991586879 creator A5003193594 @default.
- W1991586879 creator A5011516008 @default.
- W1991586879 creator A5012924122 @default.
- W1991586879 creator A5026327822 @default.
- W1991586879 creator A5035889786 @default.
- W1991586879 creator A5035943688 @default.
- W1991586879 creator A5036970339 @default.
- W1991586879 creator A5052413509 @default.
- W1991586879 creator A5063002300 @default.
- W1991586879 creator A5069295023 @default.
- W1991586879 creator A5077963659 @default.
- W1991586879 date "2014-09-24" @default.
- W1991586879 modified "2023-10-06" @default.
- W1991586879 title "A platelet protein biochip rapidly detects an Alzheimer’s disease-specific phenotype" @default.
- W1991586879 cites W1538551569 @default.
- W1991586879 cites W1806496211 @default.
- W1991586879 cites W1967474532 @default.
- W1991586879 cites W1967823816 @default.
- W1991586879 cites W1968790254 @default.
- W1991586879 cites W1970028556 @default.
- W1991586879 cites W1970553868 @default.
- W1991586879 cites W1982167563 @default.
- W1991586879 cites W1987096559 @default.
- W1991586879 cites W1991186086 @default.
- W1991586879 cites W1992762137 @default.
- W1991586879 cites W1995216906 @default.
- W1991586879 cites W1997993237 @default.
- W1991586879 cites W2001462897 @default.
- W1991586879 cites W2001925210 @default.
- W1991586879 cites W2002650850 @default.
- W1991586879 cites W2004006569 @default.
- W1991586879 cites W2005355596 @default.
- W1991586879 cites W2006859518 @default.
- W1991586879 cites W2009989809 @default.
- W1991586879 cites W2015068992 @default.
- W1991586879 cites W2017966763 @default.
- W1991586879 cites W2024424148 @default.
- W1991586879 cites W2026326610 @default.
- W1991586879 cites W2029279326 @default.
- W1991586879 cites W2032940686 @default.
- W1991586879 cites W2038285066 @default.
- W1991586879 cites W2046254690 @default.
- W1991586879 cites W2051965703 @default.
- W1991586879 cites W2052132047 @default.
- W1991586879 cites W2054093987 @default.
- W1991586879 cites W2055649795 @default.
- W1991586879 cites W2057712843 @default.
- W1991586879 cites W2062209898 @default.
- W1991586879 cites W2065413943 @default.
- W1991586879 cites W2066771631 @default.
- W1991586879 cites W2079766520 @default.
- W1991586879 cites W2084484659 @default.
- W1991586879 cites W2086331512 @default.
- W1991586879 cites W2089976860 @default.
- W1991586879 cites W2090407616 @default.
- W1991586879 cites W2091149745 @default.
- W1991586879 cites W2092086950 @default.
- W1991586879 cites W2092162796 @default.
- W1991586879 cites W2093247513 @default.
- W1991586879 cites W2093650784 @default.
- W1991586879 cites W2095422335 @default.
- W1991586879 cites W2096468633 @default.
- W1991586879 cites W2097912344 @default.
- W1991586879 cites W2105010972 @default.
- W1991586879 cites W2105181416 @default.
- W1991586879 cites W2106941916 @default.
- W1991586879 cites W2107094473 @default.
- W1991586879 cites W2110054485 @default.
- W1991586879 cites W2112712850 @default.
- W1991586879 cites W2113651744 @default.
- W1991586879 cites W2115017507 @default.
- W1991586879 cites W2121217846 @default.
- W1991586879 cites W2123830992 @default.
- W1991586879 cites W2128228199 @default.
- W1991586879 cites W2128989053 @default.
- W1991586879 cites W2130006532 @default.
- W1991586879 cites W2131215891 @default.
- W1991586879 cites W2133003904 @default.
- W1991586879 cites W2137949307 @default.
- W1991586879 cites W2146729934 @default.
- W1991586879 cites W2147177629 @default.
- W1991586879 cites W2153312670 @default.
- W1991586879 cites W2170435795 @default.
- W1991586879 cites W2185304259 @default.
- W1991586879 cites W2295393683 @default.
- W1991586879 cites W2511246053 @default.
- W1991586879 cites W4211156109 @default.
- W1991586879 doi "https://doi.org/10.1007/s00401-014-1341-8" @default.
- W1991586879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4201753" @default.
- W1991586879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25248508" @default.
- W1991586879 hasPublicationYear "2014" @default.
- W1991586879 type Work @default.
- W1991586879 sameAs 1991586879 @default.
- W1991586879 citedByCount "36" @default.
- W1991586879 countsByYear W19915868792015 @default.