Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991588891> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1991588891 endingPage "1460" @default.
- W1991588891 startingPage "1453" @default.
- W1991588891 abstract "A series of 7-substituted analogues of 2-(N-hydroxyacetamido)fluorene (1) was subjected to bioactivation by a partially purified preparation of hamster hepatic AHAT, and the rates of methylthio adduct formation resulting from the reaction of the activated intermediates with N-acetylmethionine were determined. Electronegative substituents enhanced the amount of adduct formed; this finding contrasted with the results of a previous study in which it was found that electron-donating substituents facilitated the mechanism-based inactivation of AHAT by analogues of 1. The structures of the adducts formed from reaction of the activated forms of several of the 7-substituted compounds with N-acetylmethionine and with 2'-deoxyguanosine were determined; the types of adducts formed were similar to those formed with electrophiles generated by the AHAT-catalyzed activation of 1. Electronegative substituents enhanced the amount of adducts formed in the reaction with 2'-deoxyguanosine as well as with N-acetylmethionine." @default.
- W1991588891 created "2016-06-24" @default.
- W1991588891 creator A5004597350 @default.
- W1991588891 creator A5040579052 @default.
- W1991588891 date "1985-10-01" @default.
- W1991588891 modified "2023-10-14" @default.
- W1991588891 title "Substituent effects on the bioactivation of 2-(N-hydroxyacetamido)fluorenes by N-arylhydroxamic acid N,O-acyltransferase" @default.
- W1991588891 doi "https://doi.org/10.1021/jm00148a014" @default.
- W1991588891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4045921" @default.
- W1991588891 hasPublicationYear "1985" @default.
- W1991588891 type Work @default.
- W1991588891 sameAs 1991588891 @default.
- W1991588891 citedByCount "13" @default.
- W1991588891 countsByYear W19915888912016 @default.
- W1991588891 crossrefType "journal-article" @default.
- W1991588891 hasAuthorship W1991588891A5004597350 @default.
- W1991588891 hasAuthorship W1991588891A5040579052 @default.
- W1991588891 hasConcept C108204754 @default.
- W1991588891 hasConcept C114246631 @default.
- W1991588891 hasConcept C155647269 @default.
- W1991588891 hasConcept C161790260 @default.
- W1991588891 hasConcept C178790620 @default.
- W1991588891 hasConcept C185592680 @default.
- W1991588891 hasConcept C2776211377 @default.
- W1991588891 hasConcept C2778689049 @default.
- W1991588891 hasConcept C2780441211 @default.
- W1991588891 hasConcept C50027330 @default.
- W1991588891 hasConcept C521977710 @default.
- W1991588891 hasConcept C65024703 @default.
- W1991588891 hasConcept C71240020 @default.
- W1991588891 hasConceptScore W1991588891C108204754 @default.
- W1991588891 hasConceptScore W1991588891C114246631 @default.
- W1991588891 hasConceptScore W1991588891C155647269 @default.
- W1991588891 hasConceptScore W1991588891C161790260 @default.
- W1991588891 hasConceptScore W1991588891C178790620 @default.
- W1991588891 hasConceptScore W1991588891C185592680 @default.
- W1991588891 hasConceptScore W1991588891C2776211377 @default.
- W1991588891 hasConceptScore W1991588891C2778689049 @default.
- W1991588891 hasConceptScore W1991588891C2780441211 @default.
- W1991588891 hasConceptScore W1991588891C50027330 @default.
- W1991588891 hasConceptScore W1991588891C521977710 @default.
- W1991588891 hasConceptScore W1991588891C65024703 @default.
- W1991588891 hasConceptScore W1991588891C71240020 @default.
- W1991588891 hasIssue "10" @default.
- W1991588891 hasLocation W19915888911 @default.
- W1991588891 hasLocation W19915888912 @default.
- W1991588891 hasOpenAccess W1991588891 @default.
- W1991588891 hasPrimaryLocation W19915888911 @default.
- W1991588891 hasRelatedWork W1580656906 @default.
- W1991588891 hasRelatedWork W1976041589 @default.
- W1991588891 hasRelatedWork W1991588891 @default.
- W1991588891 hasRelatedWork W2064651828 @default.
- W1991588891 hasRelatedWork W2084396605 @default.
- W1991588891 hasRelatedWork W2397483159 @default.
- W1991588891 hasRelatedWork W2953300818 @default.
- W1991588891 hasRelatedWork W3015795223 @default.
- W1991588891 hasRelatedWork W3165616499 @default.
- W1991588891 hasRelatedWork W2949439398 @default.
- W1991588891 hasVolume "28" @default.
- W1991588891 isParatext "false" @default.
- W1991588891 isRetracted "false" @default.
- W1991588891 magId "1991588891" @default.
- W1991588891 workType "article" @default.