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• W1991591737 endingPage "1693" @default.
• W1991591737 startingPage "1685" @default.
• W1991591737 abstract "Besides acting in a direct manner, cytolytic HIV-1-specific CTLs release a variety of cytokines. To assess the potential role of cytokines released by these CTLs we tested the ability of soluble products secreted by HIV-1-specific CTLs to induce HLA class I and ICAM-1 expression and to raise beta 2-microglobulin (beta 2M) concentrations in cell culture. To this end, supernatants were derived from HIV-1-specific CTLs incubated with autologous B lymphoblasts presenting either the cognate HIV-1 epitope or a control peptide. Cell lines and peripheral blood mononuclear cells (PBMCs) were incubated with these supernatants for 24-48 hr. Similarly, cells were cocultured with CTLs and their targets. This study demonstrates that in parallel with lysis of their cognate target, HIV-1-specific CTLs secreted products that stimulated HLA class I and ICAM-1 expression on cell lines and PBMCs. As few as 1000 CTLs significantly induced the expression of these molecules. In addition, secreted products of HIV-specific CTLs enhanced beta 2M release by PBMCs and Jurkat cells. These effects were mediated primarily by IFN-gamma and suggest that HIV-specific CTLs may contribute to increased HLA class I expression in infected tissue and elevated ICAM-1 and beta 2M concentrations in serum and cerebrospinal fluid of infected individuals." @default.
• W1991591737 created "2016-06-24" @default.
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• W1991591737 date "1994-12-01" @default.
• W1991591737 modified "2023-09-23" @default.
• W1991591737 title "HIV Type 1-Specific Cytotoxic T Lymphocytes Stimulate HLA Class I and Intercellular Adhesion Molecule Type 1 Expression and Increase β₂-Microglobulin Levels<i>in Vitro</i>" @default.
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• W1991591737 doi "https://doi.org/10.1089/aid.1994.10.1685" @default.
• W1991591737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7888228" @default.
• W1991591737 hasPublicationYear "1994" @default.
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