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• W1991594413 abstract "In this paper, we describe an automated, high-throughput analytical tool for the unambiguous characterization of the active component(s) of a combinatorially derived reaction mixture. We call this technique high-throughput bioassay-guided fractionation (BGF). The novel aspects of this communication are the systematization of the BGF concept, the application of BGF to combinatorial chemistry, and the high-throughput nature of the identification technique. The identification of the active component in a well mixture is an essential step for subsequent resynthesis or isolation of the active component(s) or for removal of intractable wells from further consideration. We believe the technique described is also applicable to any mixture library, provided the expected component (or components) of each well is (are) known. Example mixture libraries would include collections of synthetic chemicals and collections of purified natural products. The mixture need not come from libraries produced using parallel synthesis. The BGF tool described herein allows full utilization of highly diverse combinatorial libraries, thereby obviating costly up-front purification or extensive prescreening characterization efforts." @default.
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• W1991594413 date "2002-10-19" @default.
• W1991594413 modified "2023-10-01" @default.
• W1991594413 title "High-Throughput Bioassay-Guided Fractionation: A Technique for Rapidly Assigning Observed Activity to Individual Components of Combinatorial Libraries, Screened in HTS Bioassays" @default.
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• W1991594413 doi "https://doi.org/10.1021/cc020042e" @default.
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