Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991617645> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1991617645 endingPage "312" @default.
- W1991617645 startingPage "301" @default.
- W1991617645 abstract "Pharmacological and purification studies were carried out on lyophilised neurohypophysial tissues from Lampetra richardsoni and on control brain tissues. Crude neurohypophysial extracts contained 5.45 (4.41–6.73) mU/mg dry tissue of oxytocic activity; 3.27 mU/mg dry tissue appeared to be due to a neurohypophysial peptide which showed frog-bladder and other activities typical of arginine vasotocin (AVT). The use of trichloroacetic acid (TCA) and a carboxymethyl cellulose column resulted in a 190-fold purification of the peptide. Assay of the purified principle directly against synthetic AVT by different methods of assay suggested that it was AVT. Partition chromatography supported this finding. Control spinal cord tissues contained only low oxytocic activity (0.27 mU/mg dry tissue), but hindbrain materials showed the surprisingly high potency of 1.39 (1.19–1.62) mU/mg dry tissue. Purification of the hindbrain extract with TCA and carboxymethyl cellulose resolved an oxytocic agent with the thioglycollate lability and chromatographic and pharmacological properties of AVT. It amounted to approximately 0.18 mU/mg dry tissue, or only 12% of the total oxytocic activity present. The purification resolved small amounts of a number of oxytocic agents other than AVT. Some showed chromatographic similarities to oxytocin. However, none was destroyed by sodium thioglycollate. Any true neutral neurohypophysial principle could not have amounted to more than 1% of the AVT present (in terms of oxytocic activity), and there was no positive evidence for its existence in the neurohypophysis. The results suggest that AVT is the only neurohypophysial principle of L. richardsoni." @default.
- W1991617645 created "2016-06-24" @default.
- W1991617645 creator A5065248780 @default.
- W1991617645 creator A5071554090 @default.
- W1991617645 date "1976-07-01" @default.
- W1991617645 modified "2023-09-26" @default.
- W1991617645 title "The neurohypophysial principles of the western brook lamprey, Lampetra richardsoni: Studies in the adult" @default.
- W1991617645 cites W1032782521 @default.
- W1991617645 cites W1507950798 @default.
- W1991617645 cites W1564304750 @default.
- W1991617645 cites W1775749144 @default.
- W1991617645 cites W1963925498 @default.
- W1991617645 cites W1965771031 @default.
- W1991617645 cites W1980798101 @default.
- W1991617645 cites W1985029759 @default.
- W1991617645 cites W1991415640 @default.
- W1991617645 cites W1995294162 @default.
- W1991617645 cites W1999931602 @default.
- W1991617645 cites W2001022030 @default.
- W1991617645 cites W2009196807 @default.
- W1991617645 cites W2027424471 @default.
- W1991617645 cites W2036943834 @default.
- W1991617645 cites W2049733883 @default.
- W1991617645 cites W2055104112 @default.
- W1991617645 cites W2058358392 @default.
- W1991617645 cites W2058535252 @default.
- W1991617645 cites W2064874794 @default.
- W1991617645 cites W2085623622 @default.
- W1991617645 cites W2088637931 @default.
- W1991617645 cites W2094782886 @default.
- W1991617645 cites W2142419843 @default.
- W1991617645 cites W2198667241 @default.
- W1991617645 cites W2320976816 @default.
- W1991617645 doi "https://doi.org/10.1016/0016-6480(76)90042-3" @default.
- W1991617645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/955384" @default.
- W1991617645 hasPublicationYear "1976" @default.
- W1991617645 type Work @default.
- W1991617645 sameAs 1991617645 @default.
- W1991617645 citedByCount "13" @default.
- W1991617645 countsByYear W19916176452016 @default.
- W1991617645 crossrefType "journal-article" @default.
- W1991617645 hasAuthorship W1991617645A5065248780 @default.
- W1991617645 hasAuthorship W1991617645A5071554090 @default.
- W1991617645 hasConcept C118303440 @default.
- W1991617645 hasConcept C126322002 @default.
- W1991617645 hasConcept C134018914 @default.
- W1991617645 hasConcept C170493617 @default.
- W1991617645 hasConcept C185592680 @default.
- W1991617645 hasConcept C2776176026 @default.
- W1991617645 hasConcept C2778311276 @default.
- W1991617645 hasConcept C2779135415 @default.
- W1991617645 hasConcept C2779281246 @default.
- W1991617645 hasConcept C2780417240 @default.
- W1991617645 hasConcept C43617362 @default.
- W1991617645 hasConcept C505870484 @default.
- W1991617645 hasConcept C55493867 @default.
- W1991617645 hasConcept C71924100 @default.
- W1991617645 hasConcept C86803240 @default.
- W1991617645 hasConceptScore W1991617645C118303440 @default.
- W1991617645 hasConceptScore W1991617645C126322002 @default.
- W1991617645 hasConceptScore W1991617645C134018914 @default.
- W1991617645 hasConceptScore W1991617645C170493617 @default.
- W1991617645 hasConceptScore W1991617645C185592680 @default.
- W1991617645 hasConceptScore W1991617645C2776176026 @default.
- W1991617645 hasConceptScore W1991617645C2778311276 @default.
- W1991617645 hasConceptScore W1991617645C2779135415 @default.
- W1991617645 hasConceptScore W1991617645C2779281246 @default.
- W1991617645 hasConceptScore W1991617645C2780417240 @default.
- W1991617645 hasConceptScore W1991617645C43617362 @default.
- W1991617645 hasConceptScore W1991617645C505870484 @default.
- W1991617645 hasConceptScore W1991617645C55493867 @default.
- W1991617645 hasConceptScore W1991617645C71924100 @default.
- W1991617645 hasConceptScore W1991617645C86803240 @default.
- W1991617645 hasIssue "3" @default.
- W1991617645 hasLocation W19916176451 @default.
- W1991617645 hasLocation W19916176452 @default.
- W1991617645 hasOpenAccess W1991617645 @default.
- W1991617645 hasPrimaryLocation W19916176451 @default.
- W1991617645 hasRelatedWork W1984639015 @default.
- W1991617645 hasRelatedWork W1988627537 @default.
- W1991617645 hasRelatedWork W2008250278 @default.
- W1991617645 hasRelatedWork W2035704182 @default.
- W1991617645 hasRelatedWork W2062966719 @default.
- W1991617645 hasRelatedWork W2068318435 @default.
- W1991617645 hasRelatedWork W2088618831 @default.
- W1991617645 hasRelatedWork W2114431169 @default.
- W1991617645 hasRelatedWork W2471380398 @default.
- W1991617645 hasRelatedWork W2407537258 @default.
- W1991617645 hasVolume "29" @default.
- W1991617645 isParatext "false" @default.
- W1991617645 isRetracted "false" @default.
- W1991617645 magId "1991617645" @default.
- W1991617645 workType "article" @default.