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- W1991622936 abstract "Abstract The design rationale, synthesis, and characterization of several acetylenic substrate analogs of sterol 14α-demethylase are described. Using a tritium release assay we have been able to attain the sensitivity required to characterize (3β)-32-(ethynyl)lanost-8-en-3-ol (1) as a time-dependent irreversible inhibitor of sterol 14α-demethylase. Additional studies suggest that this is a general characteristic of the steroidal acetylenes reported herein. The structural requirements for potent inhibition are in qualitative agreement with the known substrate preferences of the enzyme." @default.
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- W1991622936 date "1991-12-01" @default.
- W1991622936 modified "2023-09-24" @default.
- W1991622936 title "Steroidal acetylenes: Mechanism-based inactivators of lanosterol 14α-demethylase" @default.
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- W1991622936 doi "https://doi.org/10.1016/0045-2068(91)90023-i" @default.
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