FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991631628> ?p ?o ?g. }

• W1991631628 endingPage "322" @default.
• W1991631628 startingPage "313" @default.
• W1991631628 abstract "The induction of phase II detoxifying enzymes is an important defense mechanism against intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional control of antioxidant response elements (AREs), this contention is experimentally unconfirmed. Since the ARE resembles the binding sequence of erythroid transcription factor NF-E2, we investigated the possibility that the phase II enzyme genes might be regulated by transcription factors that also bind to the NF-E2 sequence. The expression profiles of a number of transcription factors suggest that an Nrf2/small Maf heterodimer is the most likely candidate to fulfill this rolein vivo.To directly test these questions, we disrupted the murinenrf2 genein vivo.While the expression of phase II enzymes (e.g., glutathione S-transferase and NAD(P)H: quinone oxidoreductase) was markedly induced by a phenolic antioxidantin vivoin both wild type and heterozygous mutant mice, the induction was largely eliminated in the liver and intestine of homozygousnrf2-mutant mice. Nrf2 was found to bind to the ARE with high affinity only as a heterodimer with a small Maf protein, suggesting that Nrf2/small Maf activates gene expression directly through the ARE. These results demonstrate that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes. Thenrf2-deficient mice may prove to be a very useful model for thein vivoanalysis of chemical carcinogenesis and resistance to anti-cancer drugs." @default.
• W1991631628 created "2016-06-24" @default.
• W1991631628 creator A5004095919 @default.
• W1991631628 creator A5004986622 @default.
• W1991631628 creator A5011321820 @default.
• W1991631628 creator A5014582936 @default.
• W1991631628 creator A5018277239 @default.
• W1991631628 creator A5054943826 @default.
• W1991631628 creator A5060679925 @default.
• W1991631628 creator A5060767540 @default.
• W1991631628 creator A5067454062 @default.
• W1991631628 creator A5072809750 @default.
• W1991631628 creator A5072932144 @default.
• W1991631628 creator A5087982423 @default.
• W1991631628 date "1997-07-01" @default.
• W1991631628 modified "2023-10-18" @default.
• W1991631628 title "An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements" @default.
• W1991631628 cites W129370812 @default.
• W1991631628 cites W1502854031 @default.
• W1991631628 cites W1508786321 @default.
• W1991631628 cites W1523034549 @default.
• W1991631628 cites W153428855 @default.
• W1991631628 cites W1542817219 @default.
• W1991631628 cites W1546121111 @default.
• W1991631628 cites W1561096292 @default.
• W1991631628 cites W1566602234 @default.
• W1991631628 cites W1577965127 @default.
• W1991631628 cites W1581676497 @default.
• W1991631628 cites W1619831032 @default.
• W1991631628 cites W1842899761 @default.
• W1991631628 cites W1858268805 @default.
• W1991631628 cites W1968092959 @default.
• W1991631628 cites W1969419384 @default.
• W1991631628 cites W1971090593 @default.
• W1991631628 cites W1973595140 @default.
• W1991631628 cites W1974525592 @default.
• W1991631628 cites W1984107344 @default.
• W1991631628 cites W1991265255 @default.
• W1991631628 cites W1998503396 @default.
• W1991631628 cites W2017152149 @default.
• W1991631628 cites W2020780433 @default.
• W1991631628 cites W2027085316 @default.
• W1991631628 cites W2028553942 @default.
• W1991631628 cites W2033215389 @default.
• W1991631628 cites W2038210364 @default.
• W1991631628 cites W2042041798 @default.
• W1991631628 cites W2045965817 @default.
• W1991631628 cites W2053700159 @default.
• W1991631628 cites W2053801044 @default.
• W1991631628 cites W2060201060 @default.
• W1991631628 cites W2077643007 @default.
• W1991631628 cites W2079446105 @default.
• W1991631628 cites W2092449641 @default.
• W1991631628 cites W2100837269 @default.
• W1991631628 cites W2118495696 @default.
• W1991631628 cites W2121858619 @default.
• W1991631628 cites W2126921546 @default.
• W1991631628 cites W2148454550 @default.
• W1991631628 cites W2162356875 @default.
• W1991631628 cites W2346992041 @default.
• W1991631628 cites W2401880178 @default.
• W1991631628 cites W4294216491 @default.
• W1991631628 doi "https://doi.org/10.1006/bbrc.1997.6943" @default.
• W1991631628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9240432" @default.
• W1991631628 hasPublicationYear "1997" @default.
• W1991631628 type Work @default.
• W1991631628 sameAs 1991631628 @default.
• W1991631628 citedByCount "3444" @default.
• W1991631628 countsByYear W19916316282012 @default.
• W1991631628 countsByYear W19916316282013 @default.
• W1991631628 countsByYear W19916316282014 @default.
• W1991631628 countsByYear W19916316282015 @default.
• W1991631628 countsByYear W19916316282016 @default.
• W1991631628 countsByYear W19916316282017 @default.
• W1991631628 countsByYear W19916316282018 @default.
• W1991631628 countsByYear W19916316282019 @default.
• W1991631628 countsByYear W19916316282020 @default.
• W1991631628 countsByYear W19916316282021 @default.
• W1991631628 countsByYear W19916316282022 @default.
• W1991631628 countsByYear W19916316282023 @default.
• W1991631628 crossrefType "journal-article" @default.
• W1991631628 hasAuthorship W1991631628A5004095919 @default.
• W1991631628 hasAuthorship W1991631628A5004986622 @default.
• W1991631628 hasAuthorship W1991631628A5011321820 @default.
• W1991631628 hasAuthorship W1991631628A5014582936 @default.
• W1991631628 hasAuthorship W1991631628A5018277239 @default.
• W1991631628 hasAuthorship W1991631628A5054943826 @default.
• W1991631628 hasAuthorship W1991631628A5060679925 @default.
• W1991631628 hasAuthorship W1991631628A5060767540 @default.
• W1991631628 hasAuthorship W1991631628A5067454062 @default.
• W1991631628 hasAuthorship W1991631628A5072809750 @default.
• W1991631628 hasAuthorship W1991631628A5072932144 @default.
• W1991631628 hasAuthorship W1991631628A5087982423 @default.
• W1991631628 hasConcept C104317684 @default.
• W1991631628 hasConcept C132154277 @default.
• W1991631628 hasConcept C138885662 @default.
• W1991631628 hasConcept C143065580 @default.
• W1991631628 hasConcept C150194340 @default.

• next