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- W199164013 abstract "Prothrombin (PT) provides one of the main antigenic targets of antiphospholipid antibodies (aPL), the serologic markers of antiphospholipid syndrome (APS). First described in 1983, antibodies against PT (anti-PT) constitute the major contributor to lupus anticoagulant (LA) phenomenon. Anti-PT are currently best detected by homemade enzyme-linked immunosorbent assay (ELISA) assays, despite the many efforts made over the recent years to standardize detection methods. The prevalence of anti-PT is highly variable, depending on the selected study population: positivity rate ranges from 13.9% among systemic lupus erythematosus (SLE) subjects to 74% in LA-positive APS patients. Considering the strong correlation with LA, anti-PT have been proposed as LA confirming assays in case of ambiguous results and as an LA replacement test to overcome its technical limitations, like the interference with oral anticoagulation. Some authors have also suggested the inclusion of anti-PT in the laboratory criteria for APS diagnosis. However, the clinical relevance of anti-PT in both primary and secondary APS is still a matter of debate, with conflicting results about the association between anti-PT positivity and aPL-related clinical manifestations." @default.
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- W199164013 date "2014-01-01" @default.
- W199164013 modified "2023-10-17" @default.
- W199164013 title "Phospholipid Autoantibodies (Nonanticardiolipin)-Antiprothrombin Antibodies" @default.
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- W199164013 doi "https://doi.org/10.1016/b978-0-444-56378-1.00088-5" @default.
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