FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991656783> ?p ?o ?g. }

• W1991656783 endingPage "1450" @default.
• W1991656783 startingPage "1445" @default.
• W1991656783 abstract "An amino acid substitution (D → K) in the C3 region of HIV-1 gp120 has previously been shown to inhibit binding of virions to CD4+ cells. We have introduced the same mutation into the HIV-1 isolate LAV-IBRU, in which the mutation is denoted D373K. Here we show that the D373K envelope protein is processed and incorporated into virus particles, but that D373K virions have no detectable infectivity (below 0.1% relative to wild type). When D373K and the wild-type envelope gene were cotransfected in 293 cells at a 4:1 ratio, the resultant infectivity of the HIV-1 supernatant was reduced more than 100-fold. When the same ratio of plasmids was tested in COS-1 cells the inhibition of HIV-1 was an order of magnitude less than observed in 293 cells. COS-1 and 293 cells differed in that only 293 cells displayed saturation of virus production with respect to the envelope protein. Our data fit a simple model: when virion formation is saturated with envelope protein, expression and incorporation of a defective envelope protein imply a corresponding dilution of wild-type protein on the surface of virions. The cooperative function of wild-type envelope proteins is subsequently compromised, and a trans-dominant inhibition of virus infectivity is observed." @default.
• W1991656783 created "2016-06-24" @default.
• W1991656783 creator A5011340804 @default.
• W1991656783 creator A5015046854 @default.
• W1991656783 creator A5036018500 @default.
• W1991656783 creator A5045833157 @default.
• W1991656783 creator A5051400918 @default.
• W1991656783 creator A5071462078 @default.
• W1991656783 date "1998-11-01" @default.
• W1991656783 modified "2023-09-26" @default.
• W1991656783 title "Inhibition of HIV Type 1 Infectivity by Coexpression of a Wild-Type and a Defective Glycoprotein 120" @default.
• W1991656783 cites W128196120 @default.
• W1991656783 cites W1511867498 @default.
• W1991656783 cites W1646769147 @default.
• W1991656783 cites W1791114663 @default.
• W1991656783 cites W1926748246 @default.
• W1991656783 cites W1933773138 @default.
• W1991656783 cites W1976620670 @default.
• W1991656783 cites W1979562294 @default.
• W1991656783 cites W1992683016 @default.
• W1991656783 cites W2018609257 @default.
• W1991656783 cites W2026855844 @default.
• W1991656783 cites W2044296969 @default.
• W1991656783 cites W2047005418 @default.
• W1991656783 cites W2054921853 @default.
• W1991656783 cites W2056235838 @default.
• W1991656783 cites W2062223397 @default.
• W1991656783 cites W2064022513 @default.
• W1991656783 cites W2078883062 @default.
• W1991656783 cites W2079683200 @default.
• W1991656783 cites W2084903745 @default.
• W1991656783 cites W2086369756 @default.
• W1991656783 cites W2097501261 @default.
• W1991656783 cites W2117149353 @default.
• W1991656783 cites W2144442654 @default.
• W1991656783 cites W2145975995 @default.
• W1991656783 cites W2146285125 @default.
• W1991656783 cites W2164915889 @default.
• W1991656783 doi "https://doi.org/10.1089/aid.1998.14.1445" @default.
• W1991656783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9824322" @default.
• W1991656783 hasPublicationYear "1998" @default.
• W1991656783 type Work @default.
• W1991656783 sameAs 1991656783 @default.
• W1991656783 citedByCount "7" @default.
• W1991656783 crossrefType "journal-article" @default.
• W1991656783 hasAuthorship W1991656783A5011340804 @default.
• W1991656783 hasAuthorship W1991656783A5015046854 @default.
• W1991656783 hasAuthorship W1991656783A5036018500 @default.
• W1991656783 hasAuthorship W1991656783A5045833157 @default.
• W1991656783 hasAuthorship W1991656783A5051400918 @default.
• W1991656783 hasAuthorship W1991656783A5071462078 @default.
• W1991656783 hasConcept C104317684 @default.
• W1991656783 hasConcept C106358424 @default.
• W1991656783 hasConcept C108625454 @default.
• W1991656783 hasConcept C143065580 @default.
• W1991656783 hasConcept C153911025 @default.
• W1991656783 hasConcept C159047783 @default.
• W1991656783 hasConcept C185592680 @default.
• W1991656783 hasConcept C207583985 @default.
• W1991656783 hasConcept C22744801 @default.
• W1991656783 hasConcept C2522874641 @default.
• W1991656783 hasConcept C501734568 @default.
• W1991656783 hasConcept C54009773 @default.
• W1991656783 hasConcept C55493867 @default.
• W1991656783 hasConcept C86803240 @default.
• W1991656783 hasConcept C97380033 @default.
• W1991656783 hasConceptScore W1991656783C104317684 @default.
• W1991656783 hasConceptScore W1991656783C106358424 @default.
• W1991656783 hasConceptScore W1991656783C108625454 @default.
• W1991656783 hasConceptScore W1991656783C143065580 @default.
• W1991656783 hasConceptScore W1991656783C153911025 @default.
• W1991656783 hasConceptScore W1991656783C159047783 @default.
• W1991656783 hasConceptScore W1991656783C185592680 @default.
• W1991656783 hasConceptScore W1991656783C207583985 @default.
• W1991656783 hasConceptScore W1991656783C22744801 @default.
• W1991656783 hasConceptScore W1991656783C2522874641 @default.
• W1991656783 hasConceptScore W1991656783C501734568 @default.
• W1991656783 hasConceptScore W1991656783C54009773 @default.
• W1991656783 hasConceptScore W1991656783C55493867 @default.
• W1991656783 hasConceptScore W1991656783C86803240 @default.
• W1991656783 hasConceptScore W1991656783C97380033 @default.
• W1991656783 hasIssue "16" @default.
• W1991656783 hasLocation W19916567831 @default.
• W1991656783 hasLocation W19916567832 @default.
• W1991656783 hasOpenAccess W1991656783 @default.
• W1991656783 hasPrimaryLocation W19916567831 @default.
• W1991656783 hasRelatedWork W1953426278 @default.
• W1991656783 hasRelatedWork W2050645133 @default.
• W1991656783 hasRelatedWork W2076100628 @default.
• W1991656783 hasRelatedWork W2088644387 @default.
• W1991656783 hasRelatedWork W213396474 @default.
• W1991656783 hasRelatedWork W2139087689 @default.
• W1991656783 hasRelatedWork W2365306427 @default.
• W1991656783 hasRelatedWork W2410054136 @default.
• W1991656783 hasRelatedWork W2413506821 @default.
• W1991656783 hasRelatedWork W3097505790 @default.
• W1991656783 hasVolume "14" @default.
• W1991656783 isParatext "false" @default.

• next