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- W1991661540 abstract "DOB, 4-bromo-2,5-dimethyloxyamphetamine, a potent hallucinogen, displays high affinity for the 5-HT2 receptor in binding assays. Since 5-HT contractile responses in guinea pig trachea are mediated by 5-HT2 receptors, we assessed the activity of DOB and related analogs in this preparation. DOB acts as a partial 5-HT agonist with an EC50 = 25 nM and is blocked by the potent selective 5-HT2 receptor antagonists ketanserin, pirenperone and LY 53857, as is 5-HT. These findings indicate that DOB may be a useful agent in characterizing 5-HT2 receptor responses." @default.
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- W1991661540 date "1987-06-01" @default.
- W1991661540 modified "2023-09-27" @default.
- W1991661540 title "Potent agonist activity of DOB at 5-HT2 receptors in guinea pig trachea" @default.
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- W1991661540 doi "https://doi.org/10.1016/0014-2999(87)90345-1" @default.
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