FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991670618> ?p ?o ?g. }

• W1991670618 endingPage "6090" @default.
• W1991670618 startingPage "6085" @default.
• W1991670618 abstract "We have studied RNase P RNA (M1 RNA) cleavage of model tRNA precursors that are cleaved at two independent positions. Here we present data demonstrating that cleavage at both sites depends on the 2'-OH immediately 5' of the respective cleavage site. However, we show that the 2-amino group of a guanosine at the cleavage site plays a significant role in cleavage at one of these sites but not at the other. These data suggest that these two cleavage sites are handled differently by the ribozyme. This theory is supported by our finding that the cross-linking pattern between Ml RNA and tRNA precursors carrying 4-thioU showed distinct differences, depending on the location of the 4-thioU relative to the respective cleavage site. These findings lead us to suggest that different cleavage sites are aligned differently in the active site, possibly as a result of different binding modes of a substrate to M1 RNA. We discuss a model in which the interaction between the 3'-terminal RCCA motif (first three residues interact) of a tRNA precursor and M1 RNA plays a significant role in this process." @default.
• W1991670618 created "2016-06-24" @default.
• W1991670618 creator A5037123805 @default.
• W1991670618 creator A5048662299 @default.
• W1991670618 date "1996-06-11" @default.
• W1991670618 modified "2023-09-30" @default.
• W1991670618 title "Different cleavage sites are aligned differently in the active site of M1 RNA, the catalytic subunit of Escherichia coli RNase P." @default.
• W1991670618 cites W107378435 @default.
• W1991670618 cites W144745942 @default.
• W1991670618 cites W1551902334 @default.
• W1991670618 cites W1555193743 @default.
• W1991670618 cites W1571856798 @default.
• W1991670618 cites W1966816729 @default.
• W1991670618 cites W1970372768 @default.
• W1991670618 cites W1972051162 @default.
• W1991670618 cites W1984446518 @default.
• W1991670618 cites W2006144062 @default.
• W1991670618 cites W2011431590 @default.
• W1991670618 cites W2017716866 @default.
• W1991670618 cites W2021333801 @default.
• W1991670618 cites W2028243446 @default.
• W1991670618 cites W2040816914 @default.
• W1991670618 cites W2044368573 @default.
• W1991670618 cites W2052195409 @default.
• W1991670618 cites W2053011060 @default.
• W1991670618 cites W2061795026 @default.
• W1991670618 cites W2064495260 @default.
• W1991670618 cites W2075194716 @default.
• W1991670618 cites W2080036688 @default.
• W1991670618 cites W2085272777 @default.
• W1991670618 cites W2091637927 @default.
• W1991670618 cites W2102225325 @default.
• W1991670618 cites W2127749120 @default.
• W1991670618 cites W2138270253 @default.
• W1991670618 cites W2140909392 @default.
• W1991670618 cites W2165778448 @default.
• W1991670618 cites W2167673850 @default.
• W1991670618 cites W96239223 @default.
• W1991670618 doi "https://doi.org/10.1073/pnas.93.12.6085" @default.
• W1991670618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39193" @default.
• W1991670618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8650223" @default.
• W1991670618 hasPublicationYear "1996" @default.
• W1991670618 type Work @default.
• W1991670618 sameAs 1991670618 @default.
• W1991670618 citedByCount "48" @default.
• W1991670618 countsByYear W19916706182013 @default.
• W1991670618 countsByYear W19916706182014 @default.
• W1991670618 countsByYear W19916706182021 @default.
• W1991670618 countsByYear W19916706182023 @default.
• W1991670618 crossrefType "journal-article" @default.
• W1991670618 hasAuthorship W1991670618A5037123805 @default.
• W1991670618 hasAuthorship W1991670618A5048662299 @default.
• W1991670618 hasBestOaLocation W19916706182 @default.
• W1991670618 hasConcept C104317684 @default.
• W1991670618 hasConcept C107824862 @default.
• W1991670618 hasConcept C10879258 @default.
• W1991670618 hasConcept C133672593 @default.
• W1991670618 hasConcept C142575336 @default.
• W1991670618 hasConcept C151730666 @default.
• W1991670618 hasConcept C153957851 @default.
• W1991670618 hasConcept C166703698 @default.
• W1991670618 hasConcept C175156509 @default.
• W1991670618 hasConcept C185592680 @default.
• W1991670618 hasConcept C2777995097 @default.
• W1991670618 hasConcept C43369102 @default.
• W1991670618 hasConcept C55493867 @default.
• W1991670618 hasConcept C62531158 @default.
• W1991670618 hasConcept C67705224 @default.
• W1991670618 hasConcept C76346623 @default.
• W1991670618 hasConcept C79750893 @default.
• W1991670618 hasConcept C86803240 @default.
• W1991670618 hasConcept C96267730 @default.
• W1991670618 hasConceptScore W1991670618C104317684 @default.
• W1991670618 hasConceptScore W1991670618C107824862 @default.
• W1991670618 hasConceptScore W1991670618C10879258 @default.
• W1991670618 hasConceptScore W1991670618C133672593 @default.
• W1991670618 hasConceptScore W1991670618C142575336 @default.
• W1991670618 hasConceptScore W1991670618C151730666 @default.
• W1991670618 hasConceptScore W1991670618C153957851 @default.
• W1991670618 hasConceptScore W1991670618C166703698 @default.
• W1991670618 hasConceptScore W1991670618C175156509 @default.
• W1991670618 hasConceptScore W1991670618C185592680 @default.
• W1991670618 hasConceptScore W1991670618C2777995097 @default.
• W1991670618 hasConceptScore W1991670618C43369102 @default.
• W1991670618 hasConceptScore W1991670618C55493867 @default.
• W1991670618 hasConceptScore W1991670618C62531158 @default.
• W1991670618 hasConceptScore W1991670618C67705224 @default.
• W1991670618 hasConceptScore W1991670618C76346623 @default.
• W1991670618 hasConceptScore W1991670618C79750893 @default.
• W1991670618 hasConceptScore W1991670618C86803240 @default.
• W1991670618 hasConceptScore W1991670618C96267730 @default.
• W1991670618 hasIssue "12" @default.
• W1991670618 hasLocation W19916706181 @default.
• W1991670618 hasLocation W19916706182 @default.
• W1991670618 hasLocation W19916706183 @default.
• W1991670618 hasLocation W19916706184 @default.
• W1991670618 hasOpenAccess W1991670618 @default.
• W1991670618 hasPrimaryLocation W19916706181 @default.

• next