FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991681537> ?p ?o ?g. }

• W1991681537 endingPage "155" @default.
• W1991681537 startingPage "136" @default.
• W1991681537 abstract "This report describes the construction, optimization and validation of a battery of quantitative structure–activity relationship (QSAR) models to predict reproductive and developmental (reprotox) hazards of untested chemicals. These models run with MC4PC software to predict seven general reprotox classes: male and female reproductive toxicity, fetal dysmorphogenesis, functional toxicity, mortality, growth, and newborn behavioral toxicity. The reprotox QSARs incorporate a weight of evidence paradigm using rats, mice, and rabbit reprotox study data and are designed to identify trans-species reprotoxicants. The majority of the reprotox QSARs exhibit good predictive performance properties: high specificity (>80%), low false positives (<20%), significant receiver operating characteristic (ROC) values (>2.00), and high coverage (>80%) in 10% leave-many-out validation experiments. The QSARs are based on 627–2023 chemicals and exhibited a wide applicability domain for FDA regulated organic chemicals for which they were designed. Experiments were also performed using the MC4PC multiple module prediction technology, and ROC statistics, and adjustments to the ratio of active to inactive (A/I ratio) chemicals in training data sets were made to optimize the predictive performance of QSAR models. Results revealed that an A/I ratio of ∼40% was optimal for MC4PC. We discuss specific recommendations for the application of the reprotox QSAR battery." @default.
• W1991681537 created "2016-06-24" @default.
• W1991681537 creator A5028732124 @default.
• W1991681537 creator A5048507796 @default.
• W1991681537 creator A5059491316 @default.
• W1991681537 creator A5068454050 @default.
• W1991681537 creator A5073073925 @default.
• W1991681537 creator A5089626104 @default.
• W1991681537 date "2007-03-01" @default.
• W1991681537 modified "2023-10-16" @default.
• W1991681537 title "A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals" @default.
• W1991681537 cites W129251135 @default.
• W1991681537 cites W1966051180 @default.
• W1991681537 cites W1966989782 @default.
• W1991681537 cites W1967416911 @default.
• W1991681537 cites W1968952644 @default.
• W1991681537 cites W1971698133 @default.
• W1991681537 cites W1977008127 @default.
• W1991681537 cites W1977570503 @default.
• W1991681537 cites W1984098038 @default.
• W1991681537 cites W1992626649 @default.
• W1991681537 cites W2001839857 @default.
• W1991681537 cites W2008207702 @default.
• W1991681537 cites W2012092858 @default.
• W1991681537 cites W2015293639 @default.
• W1991681537 cites W2020032140 @default.
• W1991681537 cites W2021070595 @default.
• W1991681537 cites W2032179350 @default.
• W1991681537 cites W2038107125 @default.
• W1991681537 cites W2041297313 @default.
• W1991681537 cites W2044763542 @default.
• W1991681537 cites W2046596584 @default.
• W1991681537 cites W2064144593 @default.
• W1991681537 cites W2064414651 @default.
• W1991681537 cites W2071800578 @default.
• W1991681537 cites W2076225427 @default.
• W1991681537 cites W2079436612 @default.
• W1991681537 cites W2083933079 @default.
• W1991681537 cites W2086438054 @default.
• W1991681537 cites W2087248274 @default.
• W1991681537 cites W2089027335 @default.
• W1991681537 cites W2089955145 @default.
• W1991681537 cites W2096024963 @default.
• W1991681537 cites W2096942889 @default.
• W1991681537 cites W2117005273 @default.
• W1991681537 cites W2128800067 @default.
• W1991681537 cites W2139253683 @default.
• W1991681537 cites W2143565665 @default.
• W1991681537 cites W2149539590 @default.
• W1991681537 cites W2151063137 @default.
• W1991681537 cites W2155863033 @default.
• W1991681537 doi "https://doi.org/10.1016/j.yrtph.2006.10.001" @default.
• W1991681537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175082" @default.
• W1991681537 hasPublicationYear "2007" @default.
• W1991681537 type Work @default.
• W1991681537 sameAs 1991681537 @default.
• W1991681537 citedByCount "51" @default.
• W1991681537 countsByYear W19916815372012 @default.
• W1991681537 countsByYear W19916815372013 @default.
• W1991681537 countsByYear W19916815372014 @default.
• W1991681537 countsByYear W19916815372015 @default.
• W1991681537 countsByYear W19916815372016 @default.
• W1991681537 countsByYear W19916815372017 @default.
• W1991681537 countsByYear W19916815372018 @default.
• W1991681537 countsByYear W19916815372019 @default.
• W1991681537 countsByYear W19916815372020 @default.
• W1991681537 countsByYear W19916815372022 @default.
• W1991681537 countsByYear W19916815372023 @default.
• W1991681537 crossrefType "journal-article" @default.
• W1991681537 hasAuthorship W1991681537A5028732124 @default.
• W1991681537 hasAuthorship W1991681537A5048507796 @default.
• W1991681537 hasAuthorship W1991681537A5059491316 @default.
• W1991681537 hasAuthorship W1991681537A5068454050 @default.
• W1991681537 hasAuthorship W1991681537A5073073925 @default.
• W1991681537 hasAuthorship W1991681537A5089626104 @default.
• W1991681537 hasConcept C107908354 @default.
• W1991681537 hasConcept C116834253 @default.
• W1991681537 hasConcept C119857082 @default.
• W1991681537 hasConcept C126322002 @default.
• W1991681537 hasConcept C164126121 @default.
• W1991681537 hasConcept C172680121 @default.
• W1991681537 hasConcept C179335377 @default.
• W1991681537 hasConcept C18903297 @default.
• W1991681537 hasConcept C2779234561 @default.
• W1991681537 hasConcept C29730261 @default.
• W1991681537 hasConcept C41008148 @default.
• W1991681537 hasConcept C54355233 @default.
• W1991681537 hasConcept C58471807 @default.
• W1991681537 hasConcept C64869954 @default.
• W1991681537 hasConcept C71924100 @default.
• W1991681537 hasConcept C86803240 @default.
• W1991681537 hasConcept C99432707 @default.
• W1991681537 hasConceptScore W1991681537C107908354 @default.
• W1991681537 hasConceptScore W1991681537C116834253 @default.
• W1991681537 hasConceptScore W1991681537C119857082 @default.
• W1991681537 hasConceptScore W1991681537C126322002 @default.
• W1991681537 hasConceptScore W1991681537C164126121 @default.
• W1991681537 hasConceptScore W1991681537C172680121 @default.

• next