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- W1991685076 abstract "The present study investigates the antihyperglycaemic activity of the aqueous seed extract of Hunteria umbellata K. Schum (Apocynaceae) (HU) in alloxan-induced, high fructose- and dexamethasone-induced hyperglycaemic rats. Single, daily oral administration of 1mg/kg of glibenclamide, 50mg/kg, 100mg/kg and 200mg/kg of HU to alloxan-induced hyperglycaemic rats in groups III, IV, V and VI, respectively, for 14 days [1] caused significant dose related (p<0.05, p<0.01 and p<0.001) reductions in the fasting blood glucose when compared to the values obtained for model control (Group II) rats. In the high fructoseinduced hyperglycaemic model, daily oral administration of 66.7g/kg fructose [2] to rats for 8 weeks was associated with significant (p<0.001) hyperglycaemia, elevations in plasma glycosylated haemoglobin (HbA1c), free insulin, fasting insulin resistance indices, serum triglyceride, and cholesterol. However, concomitant oral treatments with 1mg/kg of glibenclamide, 50mg/kg, 100mg/kg, and 200mg/kg of HU extract significantly and dose dependently (p<0.05, p<0.01, and p<0.001) attenuated development of hyperglycaemia, and decreased levels of plasma HbA1c, free insulin, serum triglyceride and cholesterol, in the groups III, IV, V and VI rats, respectively, when compared to model control (Group II) rats. Similar effect was also recorded in the dexamethasone-induced hyperglycaemic rats. The results showed that the antihyperglycaemic and antihyperlipidaemic effects of HU are mediated via enhanced peripheral glucose uptake and improvements in hyperinsulinaemia." @default.
- W1991685076 created "2016-06-24" @default.
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- W1991685076 date "2009-07-01" @default.
- W1991685076 modified "2023-09-23" @default.
- W1991685076 title "Antihyperglycaemic activity of Hunteria umbellata (K. Schum) seed extract in experimental diabetes" @default.
- W1991685076 doi "https://doi.org/10.1055/s-0029-1234755" @default.
- W1991685076 hasPublicationYear "2009" @default.
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